Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Li, JJ; Hosseini-Beheshti, E; Grau, GE; Zreiqat, H; Little, CB

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.

Li, JJ Hosseini-Beheshti, E Grau, GE Zreiqat, H Little, CB

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Nanomaterials (Basel, Switzerland), 2019, 9, (2)
Issue Date:: 2019-02-14

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Field	Value	Language
dc.contributor.author	Li, JJ
dc.contributor.author	Hosseini-Beheshti, E
dc.contributor.author	Grau, GE
dc.contributor.author	Zreiqat, H
dc.contributor.author	Little, CB
dc.date.accessioned	2021-10-21T04:51:03Z
dc.date.available	2019-02-13
dc.date.available	2021-10-21T04:51:03Z
dc.date.issued	2019-02-14
dc.identifier.citation	Nanomaterials (Basel, Switzerland), 2019, 9, (2)
dc.identifier.issn	2079-4991
dc.identifier.issn	2079-4991
dc.identifier.uri	http://hdl.handle.net/10453/151188
dc.description.abstract	Extracellular vesicles (EVs) are nanoscale particles secreted by almost all cell types to facilitate intercellular communication. Stem cell-derived EVs theoretically have the same biological functions as stem cells, but offer the advantages of small size, low immunogenicity, and removal of issues such as low cell survival and unpredictable long-term behaviour associated with direct cell transplantation. They have been an area of intense interest in regenerative medicine, due to the potential to harness their anti-inflammatory and pro-regenerative effects to induce healing in a wide variety of tissues. However, the potential of using stem cell-derived EVs for treating joint injury and osteoarthritis has not yet been extensively explored. The pathogenesis of osteoarthritis, with or without prior joint injury, is not well understood, and there is a longstanding unmet clinical need to develop new treatments that provide a therapeutic effect in preventing or stopping joint degeneration, rather than merely relieving the symptoms of the disease. This review summarises the current evidence relating to stem cell-derived EVs in joint injury and osteoarthritis, providing a concise discussion of their characteristics, advantages, therapeutic effects, limitations and outlook in this exciting new area.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation	http://purl.org/au-research/grants/arc/IC170100022
dc.relation	http://purl.org/au-research/grants/nhmrc/1120249
dc.relation.ispartof	Nanomaterials (Basel, Switzerland)
dc.relation.isbasedon	10.3390/nano9020261
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0912 Materials Engineering, 1007 Nanotechnology
dc.title	Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
utslib.for	0912 Materials Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-10-21T04:50:57Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	9
utslib.citation.issue	2

Abstract:

Extracellular vesicles (EVs) are nanoscale particles secreted by almost all cell types to facilitate intercellular communication. Stem cell-derived EVs theoretically have the same biological functions as stem cells, but offer the advantages of small size, low immunogenicity, and removal of issues such as low cell survival and unpredictable long-term behaviour associated with direct cell transplantation. They have been an area of intense interest in regenerative medicine, due to the potential to harness their anti-inflammatory and pro-regenerative effects to induce healing in a wide variety of tissues. However, the potential of using stem cell-derived EVs for treating joint injury and osteoarthritis has not yet been extensively explored. The pathogenesis of osteoarthritis, with or without prior joint injury, is not well understood, and there is a longstanding unmet clinical need to develop new treatments that provide a therapeutic effect in preventing or stopping joint degeneration, rather than merely relieving the symptoms of the disease. This review summarises the current evidence relating to stem cell-derived EVs in joint injury and osteoarthritis, providing a concise discussion of their characteristics, advantages, therapeutic effects, limitations and outlook in this exciting new area.

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http://hdl.handle.net/10453/151188