Aerosol Particle Transport and Deposition in Upper and Lower Airways of Infant, Child and Adult Human Lungs

Rahman, MM; Zhao, M; Islam, MS; Dong, K; Saha, SC

Aerosol Particle Transport and Deposition in Upper and Lower Airways of Infant, Child and Adult Human Lungs

Rahman, MM Zhao, M Islam, MS Dong, K Saha, SC

Permalink

Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Atmosphere, 12, (11), pp. 1402-1402

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (7.04 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Rahman, MM
dc.contributor.author	Zhao, M
dc.contributor.author	Islam, MS
dc.contributor.author	Dong, K
dc.contributor.author	Saha, SC
dc.date.accessioned	2021-11-02T02:21:16Z
dc.date.available	2021-11-02T02:21:16Z
dc.identifier.citation	Atmosphere, 12, (11), pp. 1402-1402
dc.identifier.issn	2073-4433
dc.identifier.uri	http://hdl.handle.net/10453/151304
dc.description.abstract	<jats:p>Understanding transportation and deposition (TD) of aerosol particles in the human respiratory system can help clinical treatment of lung diseases using medicines. The lung airway diameters and the breathing capacity of human lungs normally increase with age until the age of 30. Many studies have analyzed the particle TD in the human lung airways. However, the knowledge of the nanoparticle TD in airways of infants and children with varying inhalation flow rates is still limited in the literature. This study investigates nanoparticle (5 nm ≤ dp ≤ 500 nm) TD in the lungs of infants, children, and adults. The inhalation air flow rates corresponding to three ages are considered as Qin=3.22 L/min (infant), 8.09 L/min (Child), and Qin=14 L/min (adult). It is found that less particles are deposited in upper lung airways (G0–G3) than in lower airways (G12–G15) in the lungs of all the three age groups. The results suggest that the particle deposition efficiency in lung airways increases with the decrease of particle size due to the Brownian diffusion mechanism. About 3% of 500 nm particles are deposited in airways G12–G15 for the three age groups. As the particle size is decreased to 5 nm, the deposition rate in G12–G15 is increased to over 95%. The present findings can help medical therapy by individually simulating the distribution of drug-aerosol for the patient-specific lung.</jats:p>
dc.language	en
dc.publisher	MDPI AG
dc.relation.ispartof	Atmosphere
dc.relation.isbasedon	10.3390/atmos12111402
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0401 Atmospheric Sciences, 0502 Environmental Science and Management
dc.title	Aerosol Particle Transport and Deposition in Upper and Lower Airways of Infant, Child and Adult Human Lungs
dc.type	Journal Article
utslib.citation.volume	12
utslib.for	0401 Atmospheric Sciences
utslib.for	0502 Environmental Science and Management
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2021-11-02T02:21:10Z
pubs.issue	11
pubs.publication-status	Published online
pubs.volume	12
utslib.citation.issue	11

Abstract:

Understanding transportation and deposition (TD) of aerosol particles in the human respiratory system can help clinical treatment of lung diseases using medicines. The lung airway diameters and the breathing capacity of human lungs normally increase with age until the age of 30. Many studies have analyzed the particle TD in the human lung airways. However, the knowledge of the nanoparticle TD in airways of infants and children with varying inhalation flow rates is still limited in the literature. This study investigates nanoparticle (5 nm ≤ dp ≤ 500 nm) TD in the lungs of infants, children, and adults. The inhalation air flow rates corresponding to three ages are considered as Qin=3.22 L/min (infant), 8.09 L/min (Child), and Qin=14 L/min (adult). It is found that less particles are deposited in upper lung airways (G0–G3) than in lower airways (G12–G15) in the lungs of all the three age groups. The results suggest that the particle deposition efficiency in lung airways increases with the decrease of particle size due to the Brownian diffusion mechanism. About 3% of 500 nm particles are deposited in airways G12–G15 for the three age groups. As the particle size is decreased to 5 nm, the deposition rate in G12–G15 is increased to over 95%. The present findings can help medical therapy by individually simulating the distribution of drug-aerosol for the patient-specific lung.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/151304