The Vietnam Osteoporosis Study: Rationale and design.

Ho-Pham, LT; Nguyen, TV

The Vietnam Osteoporosis Study: Rationale and design.

Ho-Pham, LT Nguyen, TV

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Osteoporosis and sarcopenia, 2017, 3, (2), pp. 90-97
Issue Date:: 2017-06-13

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Field	Value	Language
dc.contributor.author	Ho-Pham, LT
dc.contributor.author	Nguyen, TV
dc.date.accessioned	2021-11-08T22:57:29Z
dc.date.available	2017-06-04
dc.date.available	2021-11-08T22:57:29Z
dc.date.issued	2017-06-13
dc.identifier.citation	Osteoporosis and sarcopenia, 2017, 3, (2), pp. 90-97
dc.identifier.issn	2405-5255
dc.identifier.issn	2405-5263
dc.identifier.uri	http://hdl.handle.net/10453/151411
dc.description.abstract	<h4>Objectives</h4>Osteoporosis and fracture impose a significant health care burden on the contemporary populations in developing countries. The Vietnam Osteoporosis Study (VOS) sought to assess the burden of osteoporosis and its comorbidities in men and women.<h4>Methods</h4>The study was designed as a population-based family investigation in which families were randomly recruited from Ho Chi Minh City, Vietnam. Individuals were assessed for bone health, including bone mineral density (BMD) and body composition and trabecular and cortical bone properties by pQCT (peripheral quantitative computed tomography). Fasting blood samples were obtained for the analysis of plasma glucose, glycosylated hemoglobin, and bone turnover markers. Genomic DNA extraction from whole blood samples for further genetic and genomic analyses.<h4>Results</h4>We have recruited more than 4157 individuals from 817 families. The average age of participants was 51, with approximately 45% of the individuals aged 50 years and older. Approximately 3% of participants were obese (body mass index ≥ 30 kg/m<sup>2</sup>), and 21% were overweight. Notably, 11% of participants aged 40 years and older were diabetic. Among those aged 50 years and older, approximately 14% of women and 5% of men had osteoporosis (i.e., femoral neck BMD T-scores ≤ -2.5). There were modest correlations between volumetric BMD and areal BMD.<h4>Conclusions</h4>VOS is a major bone research project in Vietnam aimed at comprehensively documenting the burden osteoporosis, its co-occurrence of chronic diseases, and their underlying etiologies. The Study will make important contributions to the literature of bone health worldwide.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Osteoporosis and sarcopenia
dc.relation.isbasedon	10.1016/j.afos.2017.06.001
dc.rights	info:eu-repo/semantics/openAccess
dc.title	The Vietnam Osteoporosis Study: Rationale and design.
dc.type	Journal Article
utslib.citation.volume	3
utslib.location.activity	Netherlands
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2021-11-08T22:57:27Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	3
utslib.citation.issue	2

Abstract:

Objectives

Osteoporosis and fracture impose a significant health care burden on the contemporary populations in developing countries. The Vietnam Osteoporosis Study (VOS) sought to assess the burden of osteoporosis and its comorbidities in men and women.

Methods

The study was designed as a population-based family investigation in which families were randomly recruited from Ho Chi Minh City, Vietnam. Individuals were assessed for bone health, including bone mineral density (BMD) and body composition and trabecular and cortical bone properties by pQCT (peripheral quantitative computed tomography). Fasting blood samples were obtained for the analysis of plasma glucose, glycosylated hemoglobin, and bone turnover markers. Genomic DNA extraction from whole blood samples for further genetic and genomic analyses.

Results

We have recruited more than 4157 individuals from 817 families. The average age of participants was 51, with approximately 45% of the individuals aged 50 years and older. Approximately 3% of participants were obese (body mass index ≥ 30 kg/m²), and 21% were overweight. Notably, 11% of participants aged 40 years and older were diabetic. Among those aged 50 years and older, approximately 14% of women and 5% of men had osteoporosis (i.e., femoral neck BMD T-scores ≤ -2.5). There were modest correlations between volumetric BMD and areal BMD.

Conclusions

VOS is a major bone research project in Vietnam aimed at comprehensively documenting the burden osteoporosis, its co-occurrence of chronic diseases, and their underlying etiologies. The Study will make important contributions to the literature of bone health worldwide.

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http://hdl.handle.net/10453/151411