Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease.

Basirun, C; Ferlazzo, ML; Howell, NR; Liu, G-J; Middleton, RJ; Martinac, B; Narayanan, SA; Poole, K; Gentile, C; Chou, J

Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease.

Basirun, C Ferlazzo, ML Howell, NR Liu, G-J Middleton, RJ Martinac, B Narayanan, SA Poole, K Gentile, C

Chou, J

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Front Cell Dev Biol, 2021, 9, pp. 750775
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Basirun, C
dc.contributor.author	Ferlazzo, ML
dc.contributor.author	Howell, NR
dc.contributor.author	Liu, G-J
dc.contributor.author	Middleton, RJ
dc.contributor.author	Martinac, B
dc.contributor.author	Narayanan, SA
dc.contributor.author	Poole, K
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016
dc.date.accessioned	2021-11-29T10:57:16Z
dc.date.available	2021-10-11
dc.date.available	2021-11-29T10:57:16Z
dc.date.issued	2021
dc.identifier.citation	Front Cell Dev Biol, 2021, 9, pp. 750775
dc.identifier.issn	2296-634X
dc.identifier.issn	2296-634X
dc.identifier.uri	http://hdl.handle.net/10453/151909
dc.description.abstract	In recent years, there has been an increasing interest in space exploration, supported by the accelerated technological advancements in the field. This has led to a new potential environment that humans could be exposed to in the very near future, and therefore an increasing request to evaluate the impact this may have on our body, including health risks associated with this endeavor. A critical component in regulating the human pathophysiology is represented by the cardiovascular system, which may be heavily affected in these extreme environments of microgravity and radiation. This mini review aims to identify the impact of microgravity and radiation on the cardiovascular system. Being able to understand the effect that comes with deep space explorations, including that of microgravity and space radiation, may also allow us to get a deeper understanding of the heart and ultimately our own basic physiological processes. This information may unlock new factors to consider with space exploration whilst simultaneously increasing our knowledge of the cardiovascular system and potentially associated diseases.
dc.language	eng
dc.publisher	Frontiers Media SA
dc.relation	Australian Institute of Nuclear Science & Engineering
dc.relation	Catholic Archdiocese of Sydney
dc.relation	Heart Research Australia (formerly North Shore Heart Research Foundation)
dc.relation	http://purl.org/au-research/grants/arc/DP190101973
dc.relation.ispartof	Front Cell Dev Biol
dc.relation.isbasedon	10.3389/fcell.2021.750775
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Microgravity × Radiation: A Space Mechanobiology Approach Toward Cardiovascular Function and Disease.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2021-11-29T10:57:15Z
pubs.publication-status	Published online
pubs.volume	9

Abstract:

In recent years, there has been an increasing interest in space exploration, supported by the accelerated technological advancements in the field. This has led to a new potential environment that humans could be exposed to in the very near future, and therefore an increasing request to evaluate the impact this may have on our body, including health risks associated with this endeavor. A critical component in regulating the human pathophysiology is represented by the cardiovascular system, which may be heavily affected in these extreme environments of microgravity and radiation. This mini review aims to identify the impact of microgravity and radiation on the cardiovascular system. Being able to understand the effect that comes with deep space explorations, including that of microgravity and space radiation, may also allow us to get a deeper understanding of the heart and ultimately our own basic physiological processes. This information may unlock new factors to consider with space exploration whilst simultaneously increasing our knowledge of the cardiovascular system and potentially associated diseases.

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http://hdl.handle.net/10453/151909