Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment

Finch, AP; Gamper, E; Norman, R; Viney, R; Holzner, B; King, M; Kemmler, G

Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment

Finch, AP Gamper, E Norman, R Viney, R

Holzner, B King, M Kemmler, G

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Publisher:: Adis
Publication Type:: Journal Article
Citation:: PharmacoEconomics, 2021, 39, (9), pp. 1085-1098
Issue Date:: 2021-07-03

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Field	Value	Language
dc.contributor.author	Finch, AP
dc.contributor.author	Gamper, E
dc.contributor.author	Norman, R
dc.contributor.author	Viney, R https://orcid.org/0000-0002-0039-9635
dc.contributor.author	Holzner, B
dc.contributor.author	King, M
dc.contributor.author	Kemmler, G
dc.date.accessioned	2021-12-16T06:59:26Z
dc.date.available	2021-06-07
dc.date.available	2021-12-16T06:59:26Z
dc.date.issued	2021-07-03
dc.identifier.citation	PharmacoEconomics, 2021, 39, (9), pp. 1085-1098
dc.identifier.issn	1170-7690
dc.identifier.issn	1179-2027
dc.identifier.uri	http://hdl.handle.net/10453/152364
dc.description.abstract	Background The EORTC QLU-C10D is a preference-based measure derived from the EORTC QLQ-C30. For use in economic evaluations, country-specific value sets are needed. This study aimed to generate an EORTC QLU-C10 value set for Spain. Methods A sample of the Spanish general population completed an online discrete choice experiment. An attribute-balanced incomplete block design was used to select 960 choice tasks, with a total of 1920 health states. Each participant was randomly assigned 16 choice sets without replacement. Data were modelled using generalized estimating equations and mixed logistic regressions. Results A total of 1625 panel members were invited to participate, 1010 of whom were included in the study. Dimension decrements were generally monotonic with larger disutilities at increased severity levels. Dimensions associated with larger decrements were physical functioning and pain, while the dimension with the smallest decrement was sleep disturbances. The PITS state (i.e. worst attainable health) for the Spanish population is − 0.043. Conclusions This study generated the first Spanish value set for the QLU-C10D. This can facilitate cost-utility analyses when applied to data collected with the EORTC QLQ-C30.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Adis
dc.relation.ispartof	PharmacoEconomics
dc.relation.isbasedon	10.1007/s40273-021-01058-x
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	11 Medical and Health Sciences, 14 Economics
dc.subject.classification	Health Policy & Services
dc.subject.mesh	Humans
dc.subject.mesh	Logistic Models
dc.subject.mesh	Quality of Life
dc.subject.mesh	Cost-Benefit Analysis
dc.subject.mesh	Spain
dc.subject.mesh	Surveys and Questionnaires
dc.subject.mesh	Cost-Benefit Analysis
dc.subject.mesh	Humans
dc.subject.mesh	Logistic Models
dc.subject.mesh	Quality of Life
dc.subject.mesh	Spain
dc.subject.mesh	Surveys and Questionnaires
dc.title	Estimation of an EORTC QLU-C10 Value Set for Spain Using a Discrete Choice Experiment
dc.type	Journal Article
utslib.citation.volume	39
utslib.location.activity	New Zealand
utslib.for	11 Medical and Health Sciences
utslib.for	14 Economics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Centre for Health Economics Research and Evaluation
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2021-12-16T06:59:24Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	39
utslib.citation.issue	9

Abstract:

Background The EORTC QLU-C10D is a preference-based measure derived from the EORTC QLQ-C30. For use in economic evaluations, country-specific value sets are needed. This study aimed to generate an EORTC QLU-C10 value set for Spain. Methods A sample of the Spanish general population completed an online discrete choice experiment. An attribute-balanced incomplete block design was used to select 960 choice tasks, with a total of 1920 health states. Each participant was randomly assigned 16 choice sets without replacement. Data were modelled using generalized estimating equations and mixed logistic regressions. Results A total of 1625 panel members were invited to participate, 1010 of whom were included in the study. Dimension decrements were generally monotonic with larger disutilities at increased severity levels. Dimensions associated with larger decrements were physical functioning and pain, while the dimension with the smallest decrement was sleep disturbances. The PITS state (i.e. worst attainable health) for the Spanish population is − 0.043. Conclusions This study generated the first Spanish value set for the QLU-C10D. This can facilitate cost-utility analyses when applied to data collected with the EORTC QLQ-C30.

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http://hdl.handle.net/10453/152364