Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial.

Evans, HEL; Galvão, DA; Forbes, CC; Girard, D; Vandelanotte, C; Newton, RU; Vincent, AD; Wittert, G; Kichenadasse, G; Chambers, S; Brook, N; Short, CE

Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial.

Evans, HEL Galvão, DA Forbes, CC Girard, D Vandelanotte, C Newton, RU Vincent, AD Wittert, G Kichenadasse, G Chambers, S

Brook, N Short, CE

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Publisher:: MDPI AG
Publication Type:: Journal Article
Citation:: Cancers (Basel), 2021, 13, (23), pp. 5925-5925
Issue Date:: 2021-11-25

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Field	Value	Language
dc.contributor.author	Evans, HEL
dc.contributor.author	Galvão, DA
dc.contributor.author	Forbes, CC
dc.contributor.author	Girard, D
dc.contributor.author	Vandelanotte, C
dc.contributor.author	Newton, RU
dc.contributor.author	Vincent, AD
dc.contributor.author	Wittert, G
dc.contributor.author	Kichenadasse, G
dc.contributor.author	Chambers, S https://orcid.org/0000-0003-2369-6111
dc.contributor.author	Brook, N
dc.contributor.author	Short, CE
dc.date.accessioned	2021-12-27T23:55:09Z
dc.date.available	2021-11-19
dc.date.available	2021-12-27T23:55:09Z
dc.date.issued	2021-11-25
dc.identifier.citation	Cancers (Basel), 2021, 13, (23), pp. 5925-5925
dc.identifier.issn	2072-6694
dc.identifier.issn	2072-6694
dc.identifier.uri	http://hdl.handle.net/10453/152538
dc.description.abstract	Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote supervision. ExerciseGuide was deemed acceptable with a score ≥20 on the client satisfaction questionnaire; however, the usability score was just below the pre-specified score of ≥68 on the software usability scale. There were no serious adverse events reported. Moderate-to-vigorous physical activity levels between baseline and follow-ups were significantly higher (10.0 min per day; 95% CI = (1.3-18.6); p = 0.01) in the intervention group compared to wait-list control. There were also greater improvements in step count (1332; 95% CI = (159-2505); p = 0.02) and identified motivation (0.4, 95% CI = (0.0, 0.7); p = 0.04). Our findings provide preliminary evidence that ExerciseGuide is acceptable, safe and efficacious among individuals with metastatic prostate cancer.
dc.language	eng
dc.publisher	MDPI AG
dc.relation.ispartof	Cancers (Basel)
dc.relation.isbasedon	10.3390/cancers13235925
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.title	Acceptability and Preliminary Efficacy of a Web- and Telephone-Based Personalised Exercise Intervention for Individuals with Metastatic Prostate Cancer: The ExerciseGuide Pilot Randomised Controlled Trial.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	Switzerland
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2021-12-27T23:55:07Z
pubs.issue	23
pubs.publication-status	Published online
pubs.volume	13
utslib.citation.issue	23

Abstract:

Preliminary research has shown the effectiveness of supervised exercise-based interventions in alleviating sequela resulting from metastatic prostate cancer. However, many individuals encounter barriers that limit the uptake of face-to-face exercise. Technology-enabled interventions offer a distance-based alternative. This pilot study aimed to explore the acceptability, safety and preliminary efficacy of a web-based exercise intervention (ExerciseGuide) in individuals with metastatic prostate cancer. Forty participants (70.2 ± 8.5 years) with metastatic prostate cancer were randomised into the 8-week intervention (N = 20) or a wait-list control (N = 20). The intervention arm had access to a computer-tailored website, personalised exercise prescription and remote supervision. ExerciseGuide was deemed acceptable with a score ≥20 on the client satisfaction questionnaire; however, the usability score was just below the pre-specified score of ≥68 on the software usability scale. There were no serious adverse events reported. Moderate-to-vigorous physical activity levels between baseline and follow-ups were significantly higher (10.0 min per day; 95% CI = (1.3-18.6); p = 0.01) in the intervention group compared to wait-list control. There were also greater improvements in step count (1332; 95% CI = (159-2505); p = 0.02) and identified motivation (0.4, 95% CI = (0.0, 0.7); p = 0.04). Our findings provide preliminary evidence that ExerciseGuide is acceptable, safe and efficacious among individuals with metastatic prostate cancer.

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