Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium.

Salmon, C; Song, L; Muir, K; UKGPCS Collaborators,; Pashayan, N; Dunning, AM; Batra, J; APCB BioResource (Australian Prostate Cancer BioResource),; Chambers, S; Stanford, JL; Ostrander, EA; Park, JY; Lin, H-Y; Cussenot, O; Cancel-Tassin, G; Menegaux, F; Cordina-Duverger, E; Kogevinas, M; Llorca, J; Kaneva, R; Slavov, C; Razack, A; Lim, J; Gago-Dominguez, M; Castelao, JE; Kote-Jarai, Z; Eeles, RA; on behalf of the PRACTICAL Consortium,; Parent, M-É

Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium.

Salmon, C Song, L Muir, K UKGPCS Collaborators, Pashayan, N Dunning, AM Batra, J APCB BioResource (Australian Prostate Cancer BioResource), Chambers, S

Stanford, JL Ostrander, EA Park, JY Lin, H-Y Cussenot, O Cancel-Tassin, G Menegaux, F Cordina-Duverger, E Kogevinas, M Llorca, J Kaneva, R Slavov, C Razack, A Lim, J Gago-Dominguez, M Castelao, JE Kote-Jarai, Z Eeles, RA on behalf of the PRACTICAL Consortium, Parent, M-É

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Publisher:: Springer
Publication Type:: Journal Article
Citation:: European Journal of Epidemiology, 2021, 36, (9), pp. 913-925
Issue Date:: 2021-09

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Field	Value	Language
dc.contributor.author	Salmon, C
dc.contributor.author	Song, L
dc.contributor.author	Muir, K
dc.contributor.author	UKGPCS Collaborators,
dc.contributor.author	Pashayan, N
dc.contributor.author	Dunning, AM
dc.contributor.author	Batra, J
dc.contributor.author	APCB BioResource (Australian Prostate Cancer BioResource),
dc.contributor.author	Chambers, S https://orcid.org/0000-0003-2369-6111
dc.contributor.author	Stanford, JL
dc.contributor.author	Ostrander, EA
dc.contributor.author	Park, JY
dc.contributor.author	Lin, H-Y
dc.contributor.author	Cussenot, O
dc.contributor.author	Cancel-Tassin, G
dc.contributor.author	Menegaux, F
dc.contributor.author	Cordina-Duverger, E
dc.contributor.author	Kogevinas, M
dc.contributor.author	Llorca, J
dc.contributor.author	Kaneva, R
dc.contributor.author	Slavov, C
dc.contributor.author	Razack, A
dc.contributor.author	Lim, J
dc.contributor.author	Gago-Dominguez, M
dc.contributor.author	Castelao, JE
dc.contributor.author	Kote-Jarai, Z
dc.contributor.author	Eeles, RA
dc.contributor.author	on behalf of the PRACTICAL Consortium,
dc.contributor.author	Parent, M-É
dc.date.accessioned	2022-01-04T04:46:42Z
dc.date.available	2021-06-23
dc.date.available	2022-01-04T04:46:42Z
dc.date.issued	2021-09
dc.identifier.citation	European Journal of Epidemiology, 2021, 36, (9), pp. 913-925
dc.identifier.issn	0393-2990
dc.identifier.issn	1573-7284
dc.identifier.uri	http://hdl.handle.net/10453/152661
dc.description.abstract	While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores ≥ 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER's summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97-1.34) for local, 1.53 (95% CI 1.22-1.92) for regional, and 1.56 (95% CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Springer
dc.relation.ispartof	European Journal of Epidemiology
dc.relation.isbasedon	10.1007/s10654-021-00781-1
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1117 Public Health and Health Services
dc.subject.classification	Epidemiology
dc.subject.mesh	Adenocarcinoma
dc.subject.mesh	Aged
dc.subject.mesh	Divorce
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Male
dc.subject.mesh	Marital Status
dc.subject.mesh	Marriage
dc.subject.mesh	Middle Aged
dc.subject.mesh	Population Surveillance
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Single Person
dc.subject.mesh	Social Support
dc.subject.mesh	Humans
dc.subject.mesh	Adenocarcinoma
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Population Surveillance
dc.subject.mesh	Incidence
dc.subject.mesh	Marital Status
dc.subject.mesh	Divorce
dc.subject.mesh	Marriage
dc.subject.mesh	Single Person
dc.subject.mesh	Social Support
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Male
dc.subject.mesh	Adenocarcinoma
dc.subject.mesh	Aged
dc.subject.mesh	Divorce
dc.subject.mesh	Humans
dc.subject.mesh	Incidence
dc.subject.mesh	Male
dc.subject.mesh	Marital Status
dc.subject.mesh	Marriage
dc.subject.mesh	Middle Aged
dc.subject.mesh	Population Surveillance
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Single Person
dc.subject.mesh	Social Support
dc.title	Marital status and prostate cancer incidence: a pooled analysis of 12 case-control studies from the PRACTICAL consortium.
dc.type	Journal Article
utslib.citation.volume	36
utslib.location.activity	Netherlands
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-01-04T04:46:38Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	36
utslib.citation.issue	9

Abstract:

While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores ≥ 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER's summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97-1.34) for local, 1.53 (95% CI 1.22-1.92) for regional, and 1.56 (95% CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.

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http://hdl.handle.net/10453/152661