A Flexible Implantable Polyimide Catheter Device for Targeted Treatment of Cardiovascular Diseases by Aggregating Magnetic Nanoparticles

Zhang, H; Li, Y; Zhang, P; Ren, C; Xu, X; Sun, B; Yang, Z

A Flexible Implantable Polyimide Catheter Device for Targeted Treatment of Cardiovascular Diseases by Aggregating Magnetic Nanoparticles

Zhang, H Li, Y Zhang, P Ren, C Xu, X

Sun, B Yang, Z

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Publisher:: IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Publication Type:: Journal Article
Citation:: IEEE Transactions on Components, Packaging and Manufacturing Technology, 2021, 11, (6), pp. 911-917
Issue Date:: 2021-06-01

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Field	Value	Language
dc.contributor.author	Zhang, H
dc.contributor.author	Li, Y
dc.contributor.author	Zhang, P
dc.contributor.author	Ren, C
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Sun, B
dc.contributor.author	Yang, Z
dc.date.accessioned	2022-01-05T22:24:22Z
dc.date.available	2022-01-05T22:24:22Z
dc.date.issued	2021-06-01
dc.identifier.citation	IEEE Transactions on Components, Packaging and Manufacturing Technology, 2021, 11, (6), pp. 911-917
dc.identifier.issn	2156-3950
dc.identifier.issn	2156-3985
dc.identifier.uri	http://hdl.handle.net/10453/152711
dc.description.abstract	This article presents a flexible implantable device fabricated on a polyimide (PI) catheter for targeted treatment of cardiovascular diseases. The copper (Cu) microcoil was fabricated on a PI catheter surface using the rotated UV lithography system and surrounding electroplating technology. The simulation on the magnetic fields generated from the Cu microcoil with 0.2 A current and the driving force analysis on magnetic nanoparticles (MNPs) were conducted. The results demonstrated the precise control of MNPs motions within the magnetic fields generated from the Cu microcoil fabricated on the PI surface. The maximum temperature that increased from the magnetized Cu microcoil was 2 °C at room temperature, suggesting no induced hyperthermia. Moreover, the electrical performance of Cu microcoil was excellently stable in a variety of environments, such as wet, dry, and mechanical fatigue conditions. In vivo tests displayed great biocompatibility of the fabricated device within the carotid artery of a rat model. The directional assembly of MNPs can be achieved by a Cu microcoil fabricated on the surface of a PI catheter. The fabricated device shows notable advantages in promoting the targeted therapeutic strategy of cardiovascular diseases.
dc.language	English
dc.publisher	IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
dc.relation.ispartof	IEEE Transactions on Components, Packaging and Manufacturing Technology
dc.relation.isbasedon	10.1109/TCPMT.2021.3082923
dc.rights	info:eu-repo/semantics/closedAccess
dc.title	A Flexible Implantable Polyimide Catheter Device for Targeted Treatment of Cardiovascular Diseases by Aggregating Magnetic Nanoparticles
dc.type	Journal Article
utslib.citation.volume	11
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2022-01-05T22:24:20Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	11
utslib.citation.issue	6

Abstract:

This article presents a flexible implantable device fabricated on a polyimide (PI) catheter for targeted treatment of cardiovascular diseases. The copper (Cu) microcoil was fabricated on a PI catheter surface using the rotated UV lithography system and surrounding electroplating technology. The simulation on the magnetic fields generated from the Cu microcoil with 0.2 A current and the driving force analysis on magnetic nanoparticles (MNPs) were conducted. The results demonstrated the precise control of MNPs motions within the magnetic fields generated from the Cu microcoil fabricated on the PI surface. The maximum temperature that increased from the magnetized Cu microcoil was 2 °C at room temperature, suggesting no induced hyperthermia. Moreover, the electrical performance of Cu microcoil was excellently stable in a variety of environments, such as wet, dry, and mechanical fatigue conditions. In vivo tests displayed great biocompatibility of the fabricated device within the carotid artery of a rat model. The directional assembly of MNPs can be achieved by a Cu microcoil fabricated on the surface of a PI catheter. The fabricated device shows notable advantages in promoting the targeted therapeutic strategy of cardiovascular diseases.

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http://hdl.handle.net/10453/152711