Methylenetetrahydrofolate Reductase (MTHFR) genetic polymorphisms and the risk of infertility in couples accessing Assisted Reproductive technologies: a systematic review

Ledowsky, C; Steel, A; Schloss, J

Methylenetetrahydrofolate Reductase (MTHFR) genetic polymorphisms and the risk of infertility in couples accessing Assisted Reproductive technologies: a systematic review

Ledowsky, C Steel, A

Schloss, J

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: Advances in Integrative Medicine, 2021, 8, (3), pp. 220-229
Issue Date:: 2021-09-01

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Field	Value	Language
dc.contributor.author	Ledowsky, C
dc.contributor.author	Steel, A https://orcid.org/0000-0001-6643-9444
dc.contributor.author	Schloss, J https://orcid.org/0000-0003-1643-6215
dc.date.accessioned	2022-01-10T00:22:30Z
dc.date.available	2022-01-10T00:22:30Z
dc.date.issued	2021-09-01
dc.identifier.citation	Advances in Integrative Medicine, 2021, 8, (3), pp. 220-229
dc.identifier.issn	2212-9588
dc.identifier.issn	2212-9596
dc.identifier.uri	http://hdl.handle.net/10453/152853
dc.description.abstract	Objectives: The aim of this literature review is to examine the relationship between Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and assisted reproductive technologies in men and women accessing fertility services. Design: Systematic literature review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses Methods: This systematic literature review involved searches conducted through the Medline, EMBASE, CINAHL and Scopus databases to identify observational studies examining MTHFR polymorphism incidence in infertile couples seeking support through In vitro fertilisation and/or Fertility clinics. Results: The included studies (n = 16) identified an association with male infertility including azoospermia, oligozoospermia and teratozoospermia for the Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C. A newly-identified AA allele of the MTHFR G1793A polymorphism was found to be protective against oligospermia and males with this polymorphisms had higher sperm counts. Studies also associated the new allele MTHFR179GA GG allele with female infertility. A strong association between individuals with C677T homozygous alleles receiving assisted reproductive technology and higher AMH levels, implantation failure, and lower ovarian responsiveness was also reported. Women with A1298C polymorphisms had few follicles, lower E2 levels and were less likely to have a viable pregnancy or live birth after in vitro fertilisation. Implantation failed in one in four embryos that were homozygous for C677T. Conclusions: The MTHFR genetic polymorphism may be associated with infertility in couples seeking assisted reproductive technologies.
dc.language	en
dc.publisher	Elsevier
dc.relation.ispartof	Advances in Integrative Medicine
dc.relation.isbasedon	10.1016/j.aimed.2021.05.004
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1104 Complementary and Alternative Medicine, 1111 Nutrition and Dietetics, 1117 Public Health and Health Services
dc.title	Methylenetetrahydrofolate Reductase (MTHFR) genetic polymorphisms and the risk of infertility in couples accessing Assisted Reproductive technologies: a systematic review
dc.type	Journal Article
utslib.citation.volume	8
utslib.for	1104 Complementary and Alternative Medicine
utslib.for	1111 Nutrition and Dietetics
utslib.for	1117 Public Health and Health Services
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-01-10T00:22:29Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	8
utslib.citation.issue	3

Abstract:

Objectives: The aim of this literature review is to examine the relationship between Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and assisted reproductive technologies in men and women accessing fertility services. Design: Systematic literature review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses Methods: This systematic literature review involved searches conducted through the Medline, EMBASE, CINAHL and Scopus databases to identify observational studies examining MTHFR polymorphism incidence in infertile couples seeking support through In vitro fertilisation and/or Fertility clinics. Results: The included studies (n = 16) identified an association with male infertility including azoospermia, oligozoospermia and teratozoospermia for the Methylenetetrahydrofolate reductase polymorphisms C677T and A1298C. A newly-identified AA allele of the MTHFR G1793A polymorphism was found to be protective against oligospermia and males with this polymorphisms had higher sperm counts. Studies also associated the new allele MTHFR179GA GG allele with female infertility. A strong association between individuals with C677T homozygous alleles receiving assisted reproductive technology and higher AMH levels, implantation failure, and lower ovarian responsiveness was also reported. Women with A1298C polymorphisms had few follicles, lower E2 levels and were less likely to have a viable pregnancy or live birth after in vitro fertilisation. Implantation failed in one in four embryos that were homozygous for C677T. Conclusions: The MTHFR genetic polymorphism may be associated with infertility in couples seeking assisted reproductive technologies.

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http://hdl.handle.net/10453/152853