Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Liu Chung Ming, C; Sesperez, K; Ben-Sefer, E; Arpon, D; McGrath, K; McClements, L; Gentile, C

Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease

Liu Chung Ming, C Sesperez, K Ben-Sefer, E Arpon, D McGrath, K

McClements, L

Gentile, C

Permalink

Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Cells, 2021, 10, (4)
Issue Date:: 2021-04-14

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (866.3 kB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Liu Chung Ming, C
dc.contributor.author	Sesperez, K
dc.contributor.author	Ben-Sefer, E
dc.contributor.author	Arpon, D
dc.contributor.author	McGrath, K https://orcid.org/0000-0002-6244-3929
dc.contributor.author	McClements, L https://orcid.org/0000-0002-4911-1014
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.date.accessioned	2022-01-11T23:57:44Z
dc.date.available	2021-04-12
dc.date.available	2022-01-11T23:57:44Z
dc.date.issued	2021-04-14
dc.identifier.citation	Cells, 2021, 10, (4)
dc.identifier.issn	2073-4409
dc.identifier.issn	2073-4409
dc.identifier.uri	http://hdl.handle.net/10453/152944
dc.description.abstract	Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Cells
dc.relation.isbasedon	10.3390/cells10040899
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Female
dc.subject.mesh	Heart Failure
dc.subject.mesh	Humans
dc.subject.mesh	Microfluidics
dc.subject.mesh	Models, Biological
dc.subject.mesh	Myocardial Reperfusion Injury
dc.subject.mesh	Pre-Eclampsia
dc.subject.mesh	Pregnancy
dc.subject.mesh	Humans
dc.subject.mesh	Pre-Eclampsia
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Myocardial Reperfusion Injury
dc.subject.mesh	Microfluidics
dc.subject.mesh	Pregnancy
dc.subject.mesh	Models, Biological
dc.subject.mesh	Female
dc.subject.mesh	Heart Failure
dc.title	Considerations to Model Heart Disease in Women with Preeclampsia and Cardiovascular Disease
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Switzerland
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-01-11T23:57:41Z
pubs.issue	4
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	4

Abstract:

Preeclampsia is a multifactorial cardiovascular disorder diagnosed after 20 weeks of gestation, and is the leading cause of death for both mothers and babies in pregnancy. The pathophysiology remains poorly understood due to the variability and unpredictability of disease manifestation when studied in animal models. After preeclampsia, both mothers and offspring have a higher risk of cardiovascular disease (CVD), including myocardial infarction or heart attack and heart failure (HF). Myocardial infarction is an acute myocardial damage that can be treated through reperfusion; however, this therapeutic approach leads to ischemic/reperfusion injury (IRI), often leading to HF. In this review, we compared the current in vivo, in vitro and ex vivo model systems used to study preeclampsia, IRI and HF. Future studies aiming at evaluating CVD in preeclampsia patients could benefit from novel models that better mimic the complex scenario described in this article.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/152944