Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells

Augustine, R; Dan, P; Hasan, A; Khalaf, IM; Prasad, P; Ghosal, K; Gentile, C; McClements, L; Maureira, P

Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells

Augustine, R Dan, P Hasan, A Khalaf, IM Prasad, P Ghosal, K Gentile, C

McClements, L

Maureira, P

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Publisher:: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Publication Type:: Journal Article
Citation:: Biomedicine & Pharmacotherapy, 2021, 138, pp. 111425
Issue Date:: 2021-03-23

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Field	Value	Language
dc.contributor.author	Augustine, R
dc.contributor.author	Dan, P
dc.contributor.author	Hasan, A
dc.contributor.author	Khalaf, IM
dc.contributor.author	Prasad, P
dc.contributor.author	Ghosal, K
dc.contributor.author	Gentile, C https://orcid.org/0000-0002-3689-4275
dc.contributor.author	McClements, L https://orcid.org/0000-0002-4911-1014
dc.contributor.author	Maureira, P
dc.date.accessioned	2022-01-12T08:17:35Z
dc.date.available	2021-02-21
dc.date.available	2022-01-12T08:17:35Z
dc.date.issued	2021-03-23
dc.identifier.citation	Biomedicine & Pharmacotherapy, 2021, 138, pp. 111425
dc.identifier.issn	0753-3322
dc.identifier.issn	1950-6007
dc.identifier.uri	http://hdl.handle.net/10453/153005
dc.description.abstract	Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue engineering strategies focusing on biomaterial scaffolds incorporating cells and growth factors are emerging as highly promising for cardiac repair and regeneration. The use of stem cells within cardiac microengineered tissue constructs present an inherent ability to differentiate into cell types of the human heart. Stem cells derived from various tissues including bone marrow, dental pulp, adipose tissue and umbilical cord can be used for this purpose. Approaches ranging from stem cell injections, stem cell spheroids, cell encapsulation in a suitable hydrogel, use of prefabricated scaffold and bioprinting technology are at the forefront in the field of cardiac tissue engineering. The stem cell microenvironment plays a key role in the maintenance of stemness and/or differentiation into cardiac specific lineages. This review provides a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue. A particular emphasis is given to the roles played by the extracellular matrix (ECM) in regulating the physiological response of stem cells within cardiac tissue engineering platforms.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
dc.relation.ispartof	Biomedicine & Pharmacotherapy
dc.relation.isbasedon	10.1016/j.biopha.2021.111425
dc.rights	This is an open access article under the CC BY license
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.mesh	Animals
dc.subject.mesh	Cellular Microenvironment
dc.subject.mesh	Heart Diseases
dc.subject.mesh	Humans
dc.subject.mesh	Mesenchymal Stem Cell Transplantation
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Myocytes, Cardiac
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Transplantation, Autologous
dc.subject.mesh	Myocytes, Cardiac
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Heart Diseases
dc.subject.mesh	Mesenchymal Stem Cell Transplantation
dc.subject.mesh	Transplantation, Autologous
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Cellular Microenvironment
dc.title	Stem cell-based approaches in cardiac tissue engineering: controlling the microenvironment for autologous cells
dc.type	Journal Article
utslib.citation.volume	138
utslib.location.activity	France
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-01-12T08:16:32Z
pubs.publication-status	Published
pubs.volume	138

Abstract:

Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue engineering strategies focusing on biomaterial scaffolds incorporating cells and growth factors are emerging as highly promising for cardiac repair and regeneration. The use of stem cells within cardiac microengineered tissue constructs present an inherent ability to differentiate into cell types of the human heart. Stem cells derived from various tissues including bone marrow, dental pulp, adipose tissue and umbilical cord can be used for this purpose. Approaches ranging from stem cell injections, stem cell spheroids, cell encapsulation in a suitable hydrogel, use of prefabricated scaffold and bioprinting technology are at the forefront in the field of cardiac tissue engineering. The stem cell microenvironment plays a key role in the maintenance of stemness and/or differentiation into cardiac specific lineages. This review provides a detailed overview of the recent advances in microengineering of autologous stem cell-based tissue engineering platforms for the repair of damaged cardiac tissue. A particular emphasis is given to the roles played by the extracellular matrix (ECM) in regulating the physiological response of stem cells within cardiac tissue engineering platforms.

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http://hdl.handle.net/10453/153005