Investigating autophagy as a target in asthma and understanding how autophagy can modulate allergen-induced airway remodelling
- Publication Type:
- Thesis
- Issue Date:
- 2021
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𝗕𝗮𝗰𝗸𝗴𝗿𝗼𝘂𝗻𝗱:
Airway remodelling is an untreatable hallmark of asthma. Autophagy, the cellular homeostatic recycling mechanism has emerged as a factor playing a role in asthma and potentially airway remodelling.
𝗢𝗯𝗷𝗲𝗰𝘁𝗶𝘃𝗲𝘀:
To explore the involvement of autophagy in asthmatic airway remodelling and test autophagy inhibition as a novel therapeutic target in asthmatics.
𝗠𝗲𝘁𝗵𝗼𝗱𝗼𝗹𝗼𝗴𝘆:
Autophagy protein expression was measured in the airways of both human and mouse asthmatic tissue by immunohistochemistry. Autophagy inhibitors chloroquine (CQ) and bafilomycin A1 (BafA1) were tested in murine asthma models. Relevant lung function, cell counts, histological staining and protein expression were supported by in vitro experiments.
𝗥𝗲𝘀𝘂𝗹𝘁𝘀:
We have found increased autophagy protein expression involved in asthmatic airway remodelling in human and mice tissue. Transforming growth factor beta (TGF-β) concomitantly induces remodelling changes and the upregulation of autophagy. Autophagy inhibition reduced the pathophysiological symptoms of asthma.
𝗖𝗼𝗻𝗰𝗹𝘂𝘀𝗶𝗼𝗻:
Autophagy contributes to airway remodelling in asthma and autophagy modulation is a promising approach in developing therapies that target remodelling.
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