Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

Zhang, Y; Ramasundara, SDZ; Preketes-tardiani, RE; Cheng, V; Lu, H; Ju, LA

Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems

Zhang, Y Ramasundara, SDZ Preketes-tardiani, RE Cheng, V Lu, H

Ju, LA

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Cardiovascular Medicine, 8

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Field	Value	Language
dc.contributor.author	Zhang, Y
dc.contributor.author	Ramasundara, SDZ
dc.contributor.author	Preketes-tardiani, RE
dc.contributor.author	Cheng, V
dc.contributor.author	Lu, H https://orcid.org/0000-0001-6932-1900
dc.contributor.author	Ju, LA
dc.date.accessioned	2022-01-19T02:22:06Z
dc.date.available	2022-01-19T02:22:06Z
dc.identifier.citation	Frontiers in Cardiovascular Medicine, 8
dc.identifier.issn	2297-055X
dc.identifier.uri	http://hdl.handle.net/10453/153343
dc.description.abstract	<jats:p>Understanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have emerged to mimic microvascular anatomies and hemodynamic microenvironments, which open the floodgates for fascinating platelet mechanobiology investigations. The latest endothelialized microfluidics can even recapitulate the crosstalk between platelets and the circulatory system, including the vessel walls and plasma proteins such as von Willebrand factor. Hereby, we highlight these exciting microfluidic applications to platelet mechanobiology and platelet–circulatory system interplay as implicated in thrombosis. Last but not least, we discuss the need for microfluidic standardization and summarize the commercially available microfluidic platforms for researchers to obtain reproducible and consistent results in the field.</jats:p>
dc.language	en
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in Cardiovascular Medicine
dc.relation.isbasedon	10.3389/fcvm.2021.766513
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems
dc.type	Journal Article
utslib.citation.volume	8
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access	*
dc.date.updated	2022-01-19T02:21:56Z
pubs.publication-status	Published online
pubs.volume	8

Abstract:

Understanding how platelets can sense and respond to hemodynamic forces in disturbed blood flow and complexed vasculature is crucial to the development of more effective and safer antithrombotic therapeutics. By incorporating diverse structural and functional designs, microfluidic technologies have emerged to mimic microvascular anatomies and hemodynamic microenvironments, which open the floodgates for fascinating platelet mechanobiology investigations. The latest endothelialized microfluidics can even recapitulate the crosstalk between platelets and the circulatory system, including the vessel walls and plasma proteins such as von Willebrand factor. Hereby, we highlight these exciting microfluidic applications to platelet mechanobiology and platelet–circulatory system interplay as implicated in thrombosis. Last but not least, we discuss the need for microfluidic standardization and summarize the commercially available microfluidic platforms for researchers to obtain reproducible and consistent results in the field.

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http://hdl.handle.net/10453/153343