Heart Rate Variability as a Potential Non-invasive Marker of Blood Glucose Level

Jarman, LR; Elliott, JL; Lees, T; Clifton-Bligh, R; Simpson, AM; Nassif, N; Lal, S

Heart Rate Variability as a Potential Non-invasive Marker of Blood Glucose Level

Jarman, LR Elliott, JL Lees, T Clifton-Bligh, R Simpson, AM Nassif, N

Lal, S

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Publisher:: Pleiades Publishing Ltd
Publication Type:: Journal Article
Citation:: Human Physiology, 2021, 47, (2), pp. 209-218
Issue Date:: 2021-03-01

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Field	Value	Language
dc.contributor.author	Jarman, LR
dc.contributor.author	Elliott, JL
dc.contributor.author	Lees, T
dc.contributor.author	Clifton-Bligh, R
dc.contributor.author	Simpson, AM
dc.contributor.author	Nassif, N https://orcid.org/0000-0003-2675-8322
dc.contributor.author	Lal, S https://orcid.org/0000-0002-0911-0850
dc.date.accessioned	2022-02-09T02:57:48Z
dc.date.available	2022-02-09T02:57:48Z
dc.date.issued	2021-03-01
dc.identifier.citation	Human Physiology, 2021, 47, (2), pp. 209-218
dc.identifier.issn	0362-1197
dc.identifier.issn	1608-3164
dc.identifier.uri	http://hdl.handle.net/10453/154328
dc.description.abstract	Abstract: Currently, monitoring of blood glucose level (BGL) is constrained by the invasive nature of BGL measures. We investigated heart rate variability (HRV) parameters as potential non-invasive markers of BGL. Healthy volunteers (n = 25; aged 27 ± 9 years) uninhibited by regular medications or chronic illness were recruited for this study. BGL and HRV were assessed during fasting (9:00 am), postprandial (12:00 pm), and postabsorptive (3:00 pm) periods using self-monitoring of blood glucose techniques and ten-minute electrocardiogram, respectively. Frequency-domain HRV measures, which estimate contributions of sympathetic and parasympathetic systems to autonomic modulation of the heart, were correlated against BGL data with the following significant (p < 0.05) findings. The change in BGL from fasting to postprandial levels was negatively correlated with fasting low frequency (LF) power and total power (TP). Postprandial BGL was negatively associated with fasting LF and TP, as well as with postprandial LF, high frequency (HF), and TP. The change in BGL from postprandial to postabsorptive levels was positively correlated with fasting LF power, as well as with postprandial LF, HF, and TP. Frequency-domain HRV parameters may be useful in predicting the magnitude and direction of acute fluctuations in BGL, and further research could develop them as non-invasive markers of BGL.
dc.language	en
dc.publisher	Pleiades Publishing Ltd
dc.relation.ispartof	Human Physiology
dc.relation.isbasedon	10.1134/S0362119721020031
dc.rights	The final publication is available at Springer via http://dx.doi.org/ 10.1134/S0362119721020031
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1116 Medical Physiology
dc.subject.classification	Neurology & Neurosurgery
dc.title	Heart Rate Variability as a Potential Non-invasive Marker of Blood Glucose Level
dc.type	Journal Article
utslib.citation.volume	47
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Students
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-02-09T02:57:45Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	47
utslib.citation.issue	2

Abstract:

Abstract: Currently, monitoring of blood glucose level (BGL) is constrained by the invasive nature of BGL measures. We investigated heart rate variability (HRV) parameters as potential non-invasive markers of BGL. Healthy volunteers (n = 25; aged 27 ± 9 years) uninhibited by regular medications or chronic illness were recruited for this study. BGL and HRV were assessed during fasting (9:00 am), postprandial (12:00 pm), and postabsorptive (3:00 pm) periods using self-monitoring of blood glucose techniques and ten-minute electrocardiogram, respectively. Frequency-domain HRV measures, which estimate contributions of sympathetic and parasympathetic systems to autonomic modulation of the heart, were correlated against BGL data with the following significant (p < 0.05) findings. The change in BGL from fasting to postprandial levels was negatively correlated with fasting low frequency (LF) power and total power (TP). Postprandial BGL was negatively associated with fasting LF and TP, as well as with postprandial LF, high frequency (HF), and TP. The change in BGL from postprandial to postabsorptive levels was positively correlated with fasting LF power, as well as with postprandial LF, HF, and TP. Frequency-domain HRV parameters may be useful in predicting the magnitude and direction of acute fluctuations in BGL, and further research could develop them as non-invasive markers of BGL.

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http://hdl.handle.net/10453/154328