Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma

Joshua, DE; Vuckovic, S; Favaloro, J; Lau, KHA; Yang, S; Bryant, CE; Gibson, J; Ho, PJ

Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma

Joshua, DE Vuckovic, S Favaloro, J Lau, KHA Yang, S Bryant, CE Gibson, J Ho, PJ

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Frontiers in Immunology, 2021, 12, pp. 620596
Issue Date:: 2021-02-23

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Field	Value	Language
dc.contributor.author	Joshua, DE
dc.contributor.author	Vuckovic, S
dc.contributor.author	Favaloro, J
dc.contributor.author	Lau, KHA
dc.contributor.author	Yang, S
dc.contributor.author	Bryant, CE
dc.contributor.author	Gibson, J
dc.contributor.author	Ho, PJ
dc.date.accessioned	2022-04-27T21:12:24Z
dc.date.available	2021-01-12
dc.date.available	2022-04-27T21:12:24Z
dc.date.issued	2021-02-23
dc.identifier.citation	Frontiers in Immunology, 2021, 12, pp. 620596
dc.identifier.issn	1664-3224
dc.identifier.issn	1664-3224
dc.identifier.uri	http://hdl.handle.net/10453/156691
dc.description.abstract	The classical paradigm of host-tumor interaction, i.e. elimination, equilibrium, and escape (EEE), is reflected in the clinical behavior of myeloma which progresses from the premalignant condition, Monoclonal Gammopathy of Unknown Significance (MGUS). Despite the role of other immune cells, CD4+ regulatory T cells (Treg) and cytotoxic CD8+ T cells have emerged as the dominant effectors of host control of the myeloma clone. Progression from MGUS to myeloma is associated with alterations in Tregs and terminal effector CD8+ T cells (TTE). These changes involve CD39 and CD69 expression, affecting the adenosine pathway and residency in the bone marrow (BM) microenvironment, together with oligoclonal expansion within CD8+ TTE cells. In this mini-review article, in the context of earlier data, we summarize our recent understanding of Treg involvement in the adenosine pathway, the significance of oligoclonal expansion within CD8+ TTE cells and BM-residency of CD8+ TTE cells in MGUS and newly diagnosed multiple myeloma patients.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Frontiers in Immunology
dc.relation.isbasedon	10.3389/fimmu.2021.620596
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology, 1108 Medical Microbiology
dc.subject.mesh	Animals
dc.subject.mesh	CD8-Positive T-Lymphocytes
dc.subject.mesh	Carcinogenesis
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	Humans
dc.subject.mesh	Lymphocyte Activation
dc.subject.mesh	Monoclonal Gammopathy of Undetermined Significance
dc.subject.mesh	Multiple Myeloma
dc.subject.mesh	Precancerous Conditions
dc.subject.mesh	T-Lymphocytes, Regulatory
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	CD8-Positive T-Lymphocytes
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Multiple Myeloma
dc.subject.mesh	Precancerous Conditions
dc.subject.mesh	Lymphocyte Activation
dc.subject.mesh	Cell Proliferation
dc.subject.mesh	T-Lymphocytes, Regulatory
dc.subject.mesh	Monoclonal Gammopathy of Undetermined Significance
dc.subject.mesh	Tumor Microenvironment
dc.subject.mesh	Carcinogenesis
dc.title	Treg and Oligoclonal Expansion of Terminal Effector CD8+ T Cell as Key Players in Multiple Myeloma
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	1107 Immunology
utslib.for	1108 Medical Microbiology
utslib.copyright.status	open_access	*
dc.date.updated	2022-04-27T21:12:21Z
pubs.publication-status	Published online
pubs.volume	12

Abstract:

The classical paradigm of host-tumor interaction, i.e. elimination, equilibrium, and escape (EEE), is reflected in the clinical behavior of myeloma which progresses from the premalignant condition, Monoclonal Gammopathy of Unknown Significance (MGUS). Despite the role of other immune cells, CD4+ regulatory T cells (Treg) and cytotoxic CD8+ T cells have emerged as the dominant effectors of host control of the myeloma clone. Progression from MGUS to myeloma is associated with alterations in Tregs and terminal effector CD8+ T cells (TTE). These changes involve CD39 and CD69 expression, affecting the adenosine pathway and residency in the bone marrow (BM) microenvironment, together with oligoclonal expansion within CD8+ TTE cells. In this mini-review article, in the context of earlier data, we summarize our recent understanding of Treg involvement in the adenosine pathway, the significance of oligoclonal expansion within CD8+ TTE cells and BM-residency of CD8+ TTE cells in MGUS and newly diagnosed multiple myeloma patients.

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http://hdl.handle.net/10453/156691