The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans.

Esh, CJ; Chrismas, BCR; Mauger, AR; Cherif, A; Molphy, J; Taylor, L

The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans.

Esh, CJ Chrismas, BCR Mauger, AR Cherif, A Molphy, J Taylor, L

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Publisher:: Nature Publishing Group
Publication Type:: Journal Article
Citation:: Scientific Reports, 2021, 11, (1), pp. 1-16
Issue Date:: 2021-03-22

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Field	Value	Language
dc.contributor.author	Esh, CJ
dc.contributor.author	Chrismas, BCR
dc.contributor.author	Mauger, AR
dc.contributor.author	Cherif, A
dc.contributor.author	Molphy, J
dc.contributor.author	Taylor, L
dc.date.accessioned	2022-04-28T00:35:14Z
dc.date.available	2021-01-21
dc.date.available	2022-04-28T00:35:14Z
dc.date.issued	2021-03-22
dc.identifier.citation	Scientific Reports, 2021, 11, (1), pp. 1-16
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/156726
dc.description.abstract	Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4-1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [- 0.5 (- 0.8 to - 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (- 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.
dc.format	Electronic
dc.language	eng
dc.publisher	Nature Publishing Group
dc.relation.ispartof	Scientific Reports
dc.relation.isbasedon	10.1038/s41598-021-84563-5
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Adult
dc.subject.mesh	Biological Availability
dc.subject.mesh	Body Temperature
dc.subject.mesh	Body Temperature Regulation
dc.subject.mesh	Cold Temperature
dc.subject.mesh	Cyclooxygenase 2
dc.subject.mesh	Dinoprostone
dc.subject.mesh	Hot Temperature
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Skin Temperature
dc.subject.mesh	Adult
dc.subject.mesh	Biological Availability
dc.subject.mesh	Body Temperature
dc.subject.mesh	Body Temperature Regulation
dc.subject.mesh	Cold Temperature
dc.subject.mesh	Cyclooxygenase 2
dc.subject.mesh	Dinoprostone
dc.subject.mesh	Hot Temperature
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Skin Temperature
dc.subject.mesh	Humans
dc.subject.mesh	Dinoprostone
dc.subject.mesh	Body Temperature
dc.subject.mesh	Biological Availability
dc.subject.mesh	Body Temperature Regulation
dc.subject.mesh	Skin Temperature
dc.subject.mesh	Adult
dc.subject.mesh	Male
dc.subject.mesh	Cyclooxygenase 2
dc.subject.mesh	Cold Temperature
dc.subject.mesh	Hot Temperature
dc.title	The influence of environmental and core temperature on cyclooxygenase and PGE2 in healthy humans.
dc.type	Journal Article
utslib.citation.volume	11
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-04-28T00:35:10Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	11
utslib.citation.issue	1

Abstract:

Whether cyclooxygenase (COX)/prostaglandin E2 (PGE2) thermoregulatory pathways, observed in rodents, present in humans? Participants (n = 9) were exposed to three environments; cold (20 °C), thermoneutral (30 °C) and hot (40 °C) for 120 min. Core (Tc)/skin temperature and thermal perception were recorded every 15 min, with COX/PGE2 concentrations determined at baseline, 60 and 120 min. Linear mixed models identified differences between and within subjects/conditions. Random coefficient models determined relationships between Tc and COX/PGE2. Tc [mean (range)] increased in hot [+ 0.8 (0.4-1.2) °C; p < 0.0001; effect size (ES): 2.9], decreased in cold [- 0.5 (- 0.8 to - 0.2) °C; p < 0.0001; ES 2.6] and was unchanged in thermoneutral [+ 0.1 (- 0.2 to 0.4) °C; p = 0.3502]. A relationship between COX2/PGE2 in cold (p = 0.0012) and cold/thermoneutral [collapsed, condition and time (p = 0.0243)] was seen, with higher PGE2 associated with higher Tc. A within condition relationship between Tc/PGE2 was observed in thermoneutral (p = 0.0202) and cold/thermoneutral [collapsed, condition and time (p = 0.0079)] but not cold (p = 0.0631). The data suggests a thermogenic response of the COX/PGE2 pathway insufficient to defend Tc in cold. Further human in vivo research which manipulates COX/PGE2 bioavailability and participant acclimation/acclimatization are warranted to elucidate the influence of COX/PGE2 on Tc.

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http://hdl.handle.net/10453/156726