Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk.

Henley, JM; Nair, JD; Seager, R; Yucel, BP; Woodhall, G; Henley, BS; Talandyte, K; Needs, HI; Wilkinson, KA

Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk.

Henley, JM Nair, JD Seager, R Yucel, BP Woodhall, G Henley, BS Talandyte, K Needs, HI Wilkinson, KA

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Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Neuropharmacology, 2021, 195, pp. 108569
Issue Date:: 2021-09-01

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Field	Value	Language
dc.contributor.author	Henley, JM
dc.contributor.author	Nair, JD
dc.contributor.author	Seager, R
dc.contributor.author	Yucel, BP
dc.contributor.author	Woodhall, G
dc.contributor.author	Henley, BS
dc.contributor.author	Talandyte, K
dc.contributor.author	Needs, HI
dc.contributor.author	Wilkinson, KA
dc.date.accessioned	2022-04-30T23:24:37Z
dc.date.available	2021-04-09
dc.date.available	2022-04-30T23:24:37Z
dc.date.issued	2021-09-01
dc.identifier.citation	Neuropharmacology, 2021, 195, pp. 108569
dc.identifier.issn	0028-3908
dc.identifier.issn	1873-7064
dc.identifier.uri	http://hdl.handle.net/10453/156868
dc.description.abstract	Epilepsy is caused when rhythmic neuronal network activity escapes normal control mechanisms, resulting in seizures. There is an extensive and growing body of evidence that the onset and maintenance of epilepsy involves alterations in the trafficking, synaptic surface expression and signalling of kainate and AMPA receptors (KARs and AMPARs). The KAR subunit GluK2 and AMPAR subunit GluA2 are key determinants of the properties of their respective assembled receptors. Both subunits are subject to extensive protein interactions, RNA editing and post-translational modifications. In this review we focus on the cell biology of GluK2-containing KARs and GluA2-containing AMPARs and outline how their regulation and dysregulation is implicated in, and affected by, seizure activity. Further, we discuss role of KARs in regulating AMPAR surface expression and plasticity, and the relevance of this to epilepsy. This article is part of the special issue on 'Glutamate Receptors - Kainate receptors'.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation.ispartof	Neuropharmacology
dc.relation.isbasedon	10.1016/j.neuropharm.2021.108569
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1109 Neurosciences, 1115 Pharmacology and Pharmaceutical Sciences, 1701 Psychology
dc.subject.classification	Neurology & Neurosurgery
dc.subject.mesh	Animals
dc.subject.mesh	Brain
dc.subject.mesh	Epilepsy
dc.subject.mesh	Humans
dc.subject.mesh	Neurons
dc.subject.mesh	Receptors, AMPA
dc.subject.mesh	Receptors, Kainic Acid
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Synapses
dc.subject.mesh	Brain
dc.subject.mesh	Neurons
dc.subject.mesh	Synapses
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Epilepsy
dc.subject.mesh	Receptors, AMPA
dc.subject.mesh	Receptors, Kainic Acid
dc.subject.mesh	Signal Transduction
dc.title	Kainate and AMPA receptors in epilepsy: Cell biology, signalling pathways and possible crosstalk.
dc.type	Journal Article
utslib.citation.volume	195
utslib.location.activity	England
utslib.for	1109 Neurosciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	1701 Psychology
utslib.copyright.status	closed_access	*
dc.date.updated	2022-04-30T23:24:35Z
pubs.publication-status	Published
pubs.volume	195

Abstract:

Epilepsy is caused when rhythmic neuronal network activity escapes normal control mechanisms, resulting in seizures. There is an extensive and growing body of evidence that the onset and maintenance of epilepsy involves alterations in the trafficking, synaptic surface expression and signalling of kainate and AMPA receptors (KARs and AMPARs). The KAR subunit GluK2 and AMPAR subunit GluA2 are key determinants of the properties of their respective assembled receptors. Both subunits are subject to extensive protein interactions, RNA editing and post-translational modifications. In this review we focus on the cell biology of GluK2-containing KARs and GluA2-containing AMPARs and outline how their regulation and dysregulation is implicated in, and affected by, seizure activity. Further, we discuss role of KARs in regulating AMPAR surface expression and plasticity, and the relevance of this to epilepsy. This article is part of the special issue on 'Glutamate Receptors - Kainate receptors'.

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http://hdl.handle.net/10453/156868