The Effects of COVID-19 on the Placenta During Pregnancy.

Rad, HS; Röhl, J; Stylianou, N; Allenby, MC; Bazaz, SR; Warkiani, ME; Guimaraes, FSF; Clifton, VL; Kulasinghe, A

The Effects of COVID-19 on the Placenta During Pregnancy.

Rad, HS Röhl, J Stylianou, N Allenby, MC Bazaz, SR Warkiani, ME Guimaraes, FSF Clifton, VL Kulasinghe, A

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Publisher:: Frontiers Media SA
Publication Type:: Journal Article
Citation:: Front Immunol, 2021, 12, pp. 743022
Issue Date:: 2021

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Field	Value	Language
dc.contributor.author	Rad, HS
dc.contributor.author	Röhl, J
dc.contributor.author	Stylianou, N
dc.contributor.author	Allenby, MC
dc.contributor.author	Bazaz, SR
dc.contributor.author	Warkiani, ME
dc.contributor.author	Guimaraes, FSF
dc.contributor.author	Clifton, VL
dc.contributor.author	Kulasinghe, A
dc.date.accessioned	2022-05-14T04:16:35Z
dc.date.available	2021-08-26
dc.date.available	2022-05-14T04:16:35Z
dc.date.issued	2021
dc.identifier.citation	Front Immunol, 2021, 12, pp. 743022
dc.identifier.issn	1664-3224
dc.identifier.issn	1664-3224
dc.identifier.uri	http://hdl.handle.net/10453/157345
dc.description.abstract	Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Frontiers Media SA
dc.relation.ispartof	Front Immunol
dc.relation.isbasedon	10.3389/fimmu.2021.743022
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1107 Immunology, 1108 Medical Microbiology
dc.subject.mesh	Abortion, Spontaneous
dc.subject.mesh	Angiotensin-Converting Enzyme 2
dc.subject.mesh	COVID-19
dc.subject.mesh	Female
dc.subject.mesh	Fetal Growth Retardation
dc.subject.mesh	Humans
dc.subject.mesh	Maternal-Fetal Exchange
dc.subject.mesh	Placenta
dc.subject.mesh	Pregnancy
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	SARS-CoV-2
dc.subject.mesh	Serine Endopeptidases
dc.subject.mesh	Stillbirth
dc.subject.mesh	Placenta
dc.subject.mesh	Humans
dc.subject.mesh	Pregnancy Complications, Infectious
dc.subject.mesh	Abortion, Spontaneous
dc.subject.mesh	Fetal Growth Retardation
dc.subject.mesh	Serine Endopeptidases
dc.subject.mesh	Pregnancy
dc.subject.mesh	Maternal-Fetal Exchange
dc.subject.mesh	Female
dc.subject.mesh	Stillbirth
dc.subject.mesh	COVID-19
dc.subject.mesh	Angiotensin-Converting Enzyme 2
dc.subject.mesh	SARS-CoV-2
dc.title	The Effects of COVID-19 on the Placenta During Pregnancy.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	Switzerland
utslib.for	1107 Immunology
utslib.for	1108 Medical Microbiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-05-14T04:16:32Z
pubs.publication-status	Published online
pubs.volume	12

Abstract:

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic. The virus primarily affects the lungs where it induces respiratory distress syndrome ranging from mild to acute, however, there is a growing body of evidence supporting its negative effects on other system organs that also carry the ACE2 receptor, such as the placenta. The majority of newborns delivered from SARS-CoV-2 positive mothers test negative following delivery, suggesting that there are protective mechanisms within the placenta. There appears to be a higher incidence of pregnancy-related complications in SARS-CoV-2 positive mothers, such as miscarriage, restricted fetal growth, or still-birth. In this review, we discuss the pathobiology of COVID-19 maternal infection and the potential adverse effects associated with viral infection, and the possibility of transplacental transmission.

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http://hdl.handle.net/10453/157345