Computational evaluation of drug delivery in human respiratory tract under realistic inhalation

Tiwari, A; Jain, A; Paul, AR; Saha, SC

Computational evaluation of drug delivery in human respiratory tract under realistic inhalation

Tiwari, A Jain, A Paul, AR Saha, SC

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Publisher:: American Institute of Physics
Publication Type:: Journal Article
Citation:: Physics of Fluids, 2021, 33, (8)
Issue Date:: 2021-08-01

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Field	Value	Language
dc.contributor.author	Tiwari, A
dc.contributor.author	Jain, A
dc.contributor.author	Paul, AR
dc.contributor.author	Saha, SC
dc.date.accessioned	2022-05-30T04:28:37Z
dc.date.available	2022-05-30T04:28:37Z
dc.date.issued	2021-08-01
dc.identifier.citation	Physics of Fluids, 2021, 33, (8)
dc.identifier.issn	1070-6631
dc.identifier.issn	1089-7666
dc.identifier.uri	http://hdl.handle.net/10453/157820
dc.description.abstract	In recent years, pulmonary diseases have posed severe health problems because of increasing air pollution. Some of the promising drug delivery devices for administering the active pharmaceutical ingredients through the pulmonary route include a pressurized metered-dose inhaler and dry powder inhaler (DPI) for the management of respiratory illness. The drug settling (deposition) efficiency in different regions of a human respiratory tract (HRT) for different drug particle sizes is computed using the discrete phase model in the current study. A computer tomography-based realistic HRT replica is used for this purpose with different inhalation rates following a realistic inhalation profile through the DPI device. Unsteady flow analysis is carried out in a human respiratory system up to the sixth-generation bronchi. The particle force balance equation is used in the discrete-phase model to simulate the motion of drug particles in the HRT. Low, moderate, and high inhalation rates following realistic inhalation profiles are used in the present study. The particles of larger size are deposited more in the oral cavity and are deposited higher at a higher inhalation rate due to higher inertia force. It is also observed that drug particle size plays a key role in drug delivery through dry powder inhalers. It is also found that drugs should contain smaller-sized particles (called fine particles) to enable their reach in the distal bronchi.
dc.language	English
dc.publisher	American Institute of Physics
dc.relation.ispartof	Physics of Fluids
dc.relation.isbasedon	10.1063/5.0053980
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	01 Mathematical Sciences, 02 Physical Sciences, 09 Engineering
dc.subject.classification	Fluids & Plasmas
dc.title	Computational evaluation of drug delivery in human respiratory tract under realistic inhalation
dc.type	Journal Article
utslib.citation.volume	33
utslib.for	01 Mathematical Sciences
utslib.for	02 Physical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-05-30T04:28:35Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	33
utslib.citation.issue	8

Abstract:

In recent years, pulmonary diseases have posed severe health problems because of increasing air pollution. Some of the promising drug delivery devices for administering the active pharmaceutical ingredients through the pulmonary route include a pressurized metered-dose inhaler and dry powder inhaler (DPI) for the management of respiratory illness. The drug settling (deposition) efficiency in different regions of a human respiratory tract (HRT) for different drug particle sizes is computed using the discrete phase model in the current study. A computer tomography-based realistic HRT replica is used for this purpose with different inhalation rates following a realistic inhalation profile through the DPI device. Unsteady flow analysis is carried out in a human respiratory system up to the sixth-generation bronchi. The particle force balance equation is used in the discrete-phase model to simulate the motion of drug particles in the HRT. Low, moderate, and high inhalation rates following realistic inhalation profiles are used in the present study. The particles of larger size are deposited more in the oral cavity and are deposited higher at a higher inhalation rate due to higher inertia force. It is also observed that drug particle size plays a key role in drug delivery through dry powder inhalers. It is also found that drugs should contain smaller-sized particles (called fine particles) to enable their reach in the distal bronchi.

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http://hdl.handle.net/10453/157820