A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy

Silvani, G; Basirun, C; Wu, H; Mehner, C; Poole, K; Bradbury, P; Chou, J

A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy

Silvani, G

Basirun, C Wu, H Mehner, C Poole, K Bradbury, P Chou, J

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Publisher:: WILEY
Publication Type:: Journal Article
Citation:: Advanced Therapeutics, 2021, 4, (11)
Issue Date:: 2021-08-02

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Field	Value	Language
dc.contributor.author	Silvani, G https://orcid.org/0000-0001-6661-2817
dc.contributor.author	Basirun, C
dc.contributor.author	Wu, H
dc.contributor.author	Mehner, C
dc.contributor.author	Poole, K
dc.contributor.author	Bradbury, P
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016
dc.date.accessioned	2022-06-02T06:36:37Z
dc.date.available	2022-06-02T06:36:37Z
dc.date.issued	2021-08-02
dc.identifier.citation	Advanced Therapeutics, 2021, 4, (11)
dc.identifier.issn	2366-3987
dc.identifier.issn	2366-3987
dc.identifier.uri	http://hdl.handle.net/10453/157883
dc.description.abstract	Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and urgently requires the development of new therapeutic strategies. In this study, an innovative hybrid in vitro vascularized GBM-on-a-chip model is presented as a strategic integration of microfluidics and 3D bioprinting technologies. The system can recreate the compartmentalized brain tumor microenvironment, comprising the functional blood brain barrier (BBB) and the adjacent 3D perivascular tumor niche, by selectively mimicking physiological shear stress and cell–cell, cell–matrix mechanical interaction. The GBM-on-a-chip model was evaluated under simulated microgravity (µG) condition as a form of mechanical unloading showing a significant cell morphological and mechanotransduction response thereby indicating that gravitational forces play an important role in glioblastoma mechanical regulation. The proposed GBM-on-a-chip represents a meaningful biological tool for further research in cancer mechanobiology and pre-clinical approach in brain tumor therapy.
dc.language	English
dc.publisher	WILEY
dc.relation	http://purl.org/au-research/grants/arc/DP190101973
dc.relation.ispartof	Advanced Therapeutics
dc.relation.isbasedon	10.1002/adtp.202100106
dc.rights	info:eu-repo/semantics/openAccess
dc.title	A 3D‐Bioprinted Vascularized Glioblastoma‐on‐a‐Chip for Studying the Impact of Simulated Microgravity as a Novel Pre‐Clinical Approach in Brain Tumor Therapy
dc.type	Journal Article
utslib.citation.volume	4
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-06-02T06:36:35Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	4
utslib.citation.issue	11

Abstract:

Glioblastoma multiforme (GBM) is one of the most aggressive malignant brain tumors and urgently requires the development of new therapeutic strategies. In this study, an innovative hybrid in vitro vascularized GBM-on-a-chip model is presented as a strategic integration of microfluidics and 3D bioprinting technologies. The system can recreate the compartmentalized brain tumor microenvironment, comprising the functional blood brain barrier (BBB) and the adjacent 3D perivascular tumor niche, by selectively mimicking physiological shear stress and cell–cell, cell–matrix mechanical interaction. The GBM-on-a-chip model was evaluated under simulated microgravity (µG) condition as a form of mechanical unloading showing a significant cell morphological and mechanotransduction response thereby indicating that gravitational forces play an important role in glioblastoma mechanical regulation. The proposed GBM-on-a-chip represents a meaningful biological tool for further research in cancer mechanobiology and pre-clinical approach in brain tumor therapy.

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http://hdl.handle.net/10453/157883