From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance.
- Publisher:
- NATURE PUBLISHING GROUP
- Publication Type:
- Journal Article
- Citation:
- Sci Rep, 2016, 6, (1), pp. 32955
- Issue Date:
- 2016-09-13
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Field | Value | Language |
---|---|---|
dc.contributor.author | Asadnia, M | |
dc.contributor.author | Kottapalli, AGP | |
dc.contributor.author | Karavitaki, KD | |
dc.contributor.author | Warkiani, ME | |
dc.contributor.author | Miao, J | |
dc.contributor.author | Corey, DP | |
dc.contributor.author | Triantafyllou, M | |
dc.date.accessioned | 2022-07-12T23:26:33Z | |
dc.date.available | 2016-08-15 | |
dc.date.available | 2022-07-12T23:26:33Z | |
dc.date.issued | 2016-09-13 | |
dc.identifier.citation | Sci Rep, 2016, 6, (1), pp. 32955 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10453/158818 | |
dc.description.abstract | We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells. An artificial ciliary bundle is achieved by fabricating bundled polydimethylsiloxane (PDMS) micro-pillars with graded heights and electrospinning polyvinylidenefluoride (PVDF) piezoelectric nanofiber tip links. The piezoelectric nature of a single nanofiber tip link is confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Rheology and nanoindentation experiments are used to ensure that the viscous properties of the hyaluronic acid (HA)-based hydrogel are close to the biological cupula. A dome-shaped HA hydrogel cupula that encapsulates the artificial hair cell bundle is formed through precision drop-casting and swelling processes. Fluid drag force actuates the hydrogel cupula and deflects the micro-pillar bundle, stretching the nanofibers and generating electric charges. Functioning with principles analogous to the hair bundles, the sensors achieve a sensitivity and threshold detection limit of 300 mV/(m/s) and 8 μm/s, respectively. These self-powered, sensitive, flexible, biocompatibale and miniaturized sensors can find extensive applications in navigation and maneuvering of underwater robots, artificial hearing systems, biomedical and microfluidic devices. | |
dc.format | Electronic | |
dc.language | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.relation.ispartof | Sci Rep | |
dc.relation.isbasedon | 10.1038/srep32955 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Biocompatible Materials | |
dc.subject.mesh | Biomimetic Materials | |
dc.subject.mesh | Biosensing Techniques | |
dc.subject.mesh | Cilia | |
dc.subject.mesh | Dimethylpolysiloxanes | |
dc.subject.mesh | Equipment Design | |
dc.subject.mesh | Hair Cells, Auditory | |
dc.subject.mesh | Hydrogels | |
dc.subject.mesh | Mechanical Phenomena | |
dc.subject.mesh | Mechanotransduction, Cellular | |
dc.subject.mesh | Micro-Electrical-Mechanical Systems | |
dc.subject.mesh | Nanofibers | |
dc.subject.mesh | Nanotechnology | |
dc.subject.mesh | Polyvinyls | |
dc.subject.mesh | Rheology | |
dc.subject.mesh | Cilia | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Polyvinyls | |
dc.subject.mesh | Dimethylpolysiloxanes | |
dc.subject.mesh | Biocompatible Materials | |
dc.subject.mesh | Hydrogels | |
dc.subject.mesh | Equipment Design | |
dc.subject.mesh | Biosensing Techniques | |
dc.subject.mesh | Rheology | |
dc.subject.mesh | Mechanotransduction, Cellular | |
dc.subject.mesh | Nanotechnology | |
dc.subject.mesh | Biomimetic Materials | |
dc.subject.mesh | Hair Cells, Auditory | |
dc.subject.mesh | Mechanical Phenomena | |
dc.subject.mesh | Micro-Electrical-Mechanical Systems | |
dc.subject.mesh | Nanofibers | |
dc.title | From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance. | |
dc.type | Journal Article | |
utslib.citation.volume | 6 | |
utslib.location.activity | England | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | open_access | * |
dc.date.updated | 2022-07-12T23:26:28Z | |
pubs.issue | 1 | |
pubs.publication-status | Published online | |
pubs.volume | 6 | |
utslib.citation.issue | 1 |
Abstract:
We report the development of a new class of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosensory ciliary bundles in biological hair cells. An artificial ciliary bundle is achieved by fabricating bundled polydimethylsiloxane (PDMS) micro-pillars with graded heights and electrospinning polyvinylidenefluoride (PVDF) piezoelectric nanofiber tip links. The piezoelectric nature of a single nanofiber tip link is confirmed by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). Rheology and nanoindentation experiments are used to ensure that the viscous properties of the hyaluronic acid (HA)-based hydrogel are close to the biological cupula. A dome-shaped HA hydrogel cupula that encapsulates the artificial hair cell bundle is formed through precision drop-casting and swelling processes. Fluid drag force actuates the hydrogel cupula and deflects the micro-pillar bundle, stretching the nanofibers and generating electric charges. Functioning with principles analogous to the hair bundles, the sensors achieve a sensitivity and threshold detection limit of 300 mV/(m/s) and 8 μm/s, respectively. These self-powered, sensitive, flexible, biocompatibale and miniaturized sensors can find extensive applications in navigation and maneuvering of underwater robots, artificial hearing systems, biomedical and microfluidic devices.
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