Numerical and experimental study of capillary-driven flow of PCR solution in hybrid hydrophobic microfluidic networks.
- Publisher:
- SPRINGER
- Publication Type:
- Journal Article
- Citation:
- Biomed Microdevices, 2016, 18, (4), pp. 68
- Issue Date:
- 2016-08
Closed Access
Filename | Description | Size | |||
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Ramalingam2016_Article_NumericalAndExperimentalStudyO.pdf | Published version | 7.53 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Ramalingam, N | |
dc.contributor.author | Warkiani, ME | |
dc.contributor.author | Ramalingam, N | |
dc.contributor.author | Keshavarzi, G | |
dc.contributor.author | Hao-Bing, L | |
dc.contributor.author | Hai-Qing, TG | |
dc.date.accessioned | 2022-07-13T06:28:58Z | |
dc.date.available | 2022-07-13T06:28:58Z | |
dc.date.issued | 2016-08 | |
dc.identifier.citation | Biomed Microdevices, 2016, 18, (4), pp. 68 | |
dc.identifier.issn | 1387-2176 | |
dc.identifier.issn | 1572-8781 | |
dc.identifier.uri | http://hdl.handle.net/10453/158861 | |
dc.description.abstract | Capillary-driven microfluidics is essential for development of point-of-care diagnostic micro-devices. Polymerase chain reaction (PCR)-based micro-devices are widely developed and used in such point-of-care settings. It is imperative to characterize the fluid parameters of PCR solution for designing efficient capillary-driven microfluidic networks. Generally, for numeric modelling, the fluid parameters of PCR solution are approximated to that of water. This procedure leads to inaccurate results, which are discrepant to experimental data. This paper describes mathematical modeling and experimental validation of capillary-driven flow inside Poly-(dimethyl) siloxane (PDMS)-glass hybrid micro-channels. Using experimentally measured PCR fluid parameters, the capillary meniscus displacement in PDMS-glass microfluidic ladder network is simulated using computational fluid dynamic (CFD), and experimentally verified to match with the simulated data. | |
dc.format | ||
dc.language | eng | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | Biomed Microdevices | |
dc.relation.isbasedon | 10.1007/s10544-016-0099-2 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0903 Biomedical Engineering, 0912 Materials Engineering | |
dc.subject.classification | Analytical Chemistry | |
dc.subject.mesh | Dimethylpolysiloxanes | |
dc.subject.mesh | Glass | |
dc.subject.mesh | Hydrophobic and Hydrophilic Interactions | |
dc.subject.mesh | Microfluidic Analytical Techniques | |
dc.subject.mesh | Microfluidics | |
dc.subject.mesh | Models, Theoretical | |
dc.subject.mesh | Nylons | |
dc.subject.mesh | Octoxynol | |
dc.subject.mesh | Point-of-Care Systems | |
dc.subject.mesh | Polymerase Chain Reaction | |
dc.subject.mesh | Solutions | |
dc.subject.mesh | Surface Properties | |
dc.subject.mesh | Octoxynol | |
dc.subject.mesh | Dimethylpolysiloxanes | |
dc.subject.mesh | Glass | |
dc.subject.mesh | Nylons | |
dc.subject.mesh | Solutions | |
dc.subject.mesh | Microfluidic Analytical Techniques | |
dc.subject.mesh | Polymerase Chain Reaction | |
dc.subject.mesh | Microfluidics | |
dc.subject.mesh | Surface Properties | |
dc.subject.mesh | Models, Theoretical | |
dc.subject.mesh | Point-of-Care Systems | |
dc.subject.mesh | Hydrophobic and Hydrophilic Interactions | |
dc.title | Numerical and experimental study of capillary-driven flow of PCR solution in hybrid hydrophobic microfluidic networks. | |
dc.type | Journal Article | |
utslib.citation.volume | 18 | |
utslib.location.activity | United States | |
utslib.for | 0903 Biomedical Engineering | |
utslib.for | 0912 Materials Engineering | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Strength - CHT - Health Technologies | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
pubs.organisational-group | /University of Technology Sydney/Centre for Health Technologies (CHT) | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-07-13T06:28:57Z | |
pubs.issue | 4 | |
pubs.publication-status | Published | |
pubs.volume | 18 | |
utslib.citation.issue | 4 |
Abstract:
Capillary-driven microfluidics is essential for development of point-of-care diagnostic micro-devices. Polymerase chain reaction (PCR)-based micro-devices are widely developed and used in such point-of-care settings. It is imperative to characterize the fluid parameters of PCR solution for designing efficient capillary-driven microfluidic networks. Generally, for numeric modelling, the fluid parameters of PCR solution are approximated to that of water. This procedure leads to inaccurate results, which are discrepant to experimental data. This paper describes mathematical modeling and experimental validation of capillary-driven flow inside Poly-(dimethyl) siloxane (PDMS)-glass hybrid micro-channels. Using experimentally measured PCR fluid parameters, the capillary meniscus displacement in PDMS-glass microfluidic ladder network is simulated using computational fluid dynamic (CFD), and experimentally verified to match with the simulated data.
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