Two-Layer Red Blood Cell Membrane Model Using the Discrete Element Method

Barns, S; Sauret, E; Saha, S; Flower, R; Gu, YT

Two-Layer Red Blood Cell Membrane Model Using the Discrete Element Method

Barns, S Sauret, E Saha, S

Flower, R Gu, YT

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Publisher:: Trans Tech Publications, Ltd.
Publication Type:: Journal Article
Citation:: Applied Mechanics and Materials, 2016, 846, pp. 270-275
Issue Date:: 2016-07-01

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Field	Value	Language
dc.contributor.author	Barns, S
dc.contributor.author	Sauret, E
dc.contributor.author	Saha, S https://orcid.org/0000-0002-9962-8919
dc.contributor.author	Flower, R
dc.contributor.author	Gu, YT
dc.date.accessioned	2022-07-15T23:54:26Z
dc.date.available	2022-07-15T23:54:26Z
dc.date.issued	2016-07-01
dc.identifier.citation	Applied Mechanics and Materials, 2016, 846, pp. 270-275
dc.identifier.issn	1660-9336
dc.identifier.issn	1662-7482
dc.identifier.uri	http://hdl.handle.net/10453/158955
dc.description.abstract	<jats:p>The red blood cell (RBC) membrane consists of a lipid bilayer and spectrin-based cytoskeleton, which enclose haemoglobin-rich fluid. Numerical models of RBCs typically integrate the two membrane components into a single layer, preventing investigation of bilayer-cytoskeleton interaction. To address this constraint, a new RBC model which considers the bilayer and cytoskeleton separately is developed using the discrete element method (DEM). This is completed in 2D as a proof-of-concept, with an extension to 3D planned in the future. Resting RBC morphology predicted by the two-layer model is compared to an equivalent and well-established composite (one-layer) model with excellent agreement for critical cell dimensions. A parametric study is performed where area reduction ratio and spring constants are varied. It is found that predicted resting geometry is relatively insensitive to changes in spring stiffness, but a shape variation is observed for reduction ratio changes as expected.</jats:p>
dc.language	en
dc.publisher	Trans Tech Publications, Ltd.
dc.relation.ispartof	Applied Mechanics and Materials
dc.relation.isbasedon	10.4028/www.scientific.net/amm.846.270
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	09 Engineering
dc.title	Two-Layer Red Blood Cell Membrane Model Using the Discrete Element Method
dc.type	Journal Article
utslib.citation.volume	846
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2022-07-15T23:54:25Z
pubs.publication-status	Published online
pubs.volume	846

Abstract:

The red blood cell (RBC) membrane consists of a lipid bilayer and spectrin-based cytoskeleton, which enclose haemoglobin-rich fluid. Numerical models of RBCs typically integrate the two membrane components into a single layer, preventing investigation of bilayer-cytoskeleton interaction. To address this constraint, a new RBC model which considers the bilayer and cytoskeleton separately is developed using the discrete element method (DEM). This is completed in 2D as a proof-of-concept, with an extension to 3D planned in the future. Resting RBC morphology predicted by the two-layer model is compared to an equivalent and well-established composite (one-layer) model with excellent agreement for critical cell dimensions. A parametric study is performed where area reduction ratio and spring constants are varied. It is found that predicted resting geometry is relatively insensitive to changes in spring stiffness, but a shape variation is observed for reduction ratio changes as expected.

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http://hdl.handle.net/10453/158955