A coupled SPH-DEM approach to model the interactions between multiple red blood cells in motion in capillaries

Polwaththe-Gallage, HN; Saha, SC; Sauret, E; Flower, R; Gu, Y

A coupled SPH-DEM approach to model the interactions between multiple red blood cells in motion in capillaries

Polwaththe-Gallage, HN Saha, SC Sauret, E Flower, R Gu, Y

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Publisher:: SPRINGER HEIDELBERG
Publication Type:: Journal Article
Citation:: International Journal of Mechanics and Materials in Design, 2016, 12, (4), pp. 477-494
Issue Date:: 2016-12-01

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Field	Value	Language
dc.contributor.author	Polwaththe-Gallage, HN
dc.contributor.author	Saha, SC
dc.contributor.author	Sauret, E
dc.contributor.author	Flower, R
dc.contributor.author	Gu, Y
dc.date.accessioned	2022-07-16T00:28:27Z
dc.date.available	2022-07-16T00:28:27Z
dc.date.issued	2016-12-01
dc.identifier.citation	International Journal of Mechanics and Materials in Design, 2016, 12, (4), pp. 477-494
dc.identifier.issn	1569-1713
dc.identifier.issn	1573-8841
dc.identifier.uri	http://hdl.handle.net/10453/158959
dc.description.abstract	Red blood cells (RBCs) are the most common type of blood cells in the blood and 99 % of the blood cells are RBCs. During the circulation of blood in the cardiovascular network, RBCs squeeze through the tiny blood vessels (capillaries). They exhibit various types of motions and deformed shapes, when flowing through these capillaries with diameters varying between 5 and 10 µm. RBCs occupy about 45 % of the whole blood volume and the interaction between the RBCs directly influences on the motion and the deformation of the RBCs. However, most of the previous numerical studies have explored the motion and deformation of a single RBC when the interaction between RBCs has been neglected. In this study, motion and deformation of two 2D (two-dimensional) RBCs in capillaries are comprehensively explored using a coupled smoothed particle hydrodynamics (SPH) and discrete element method (DEM) model. In order to clearly model the interactions between RBCs, only two RBCs are considered in this study even though blood with RBCs is continuously flowing through the blood vessels. A spring network based on the DEM is employed to model the viscoelastic membrane of the RBC while the inside and outside fluid of RBC is modelled by SPH. The effect of the initial distance between two RBCs, membrane bending stiffness (Kb) of one RBC and undeformed diameter of one RBC on the motion and deformation of both RBCs in a uniform capillary is studied. Finally, the deformation behavior of two RBCs in a stenosed capillary is also examined. Simulation results reveal that the interaction between RBCs has significant influence on their motion and deformation.
dc.language	English
dc.publisher	SPRINGER HEIDELBERG
dc.relation.ispartof	International Journal of Mechanics and Materials in Design
dc.relation.isbasedon	10.1007/s10999-015-9328-8
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0913 Mechanical Engineering
dc.title	A coupled SPH-DEM approach to model the interactions between multiple red blood cells in motion in capillaries
dc.type	Journal Article
utslib.citation.volume	12
utslib.for	0913 Mechanical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2022-07-16T00:28:26Z
pubs.issue	4
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	4

Abstract:

Red blood cells (RBCs) are the most common type of blood cells in the blood and 99 % of the blood cells are RBCs. During the circulation of blood in the cardiovascular network, RBCs squeeze through the tiny blood vessels (capillaries). They exhibit various types of motions and deformed shapes, when flowing through these capillaries with diameters varying between 5 and 10 µm. RBCs occupy about 45 % of the whole blood volume and the interaction between the RBCs directly influences on the motion and the deformation of the RBCs. However, most of the previous numerical studies have explored the motion and deformation of a single RBC when the interaction between RBCs has been neglected. In this study, motion and deformation of two 2D (two-dimensional) RBCs in capillaries are comprehensively explored using a coupled smoothed particle hydrodynamics (SPH) and discrete element method (DEM) model. In order to clearly model the interactions between RBCs, only two RBCs are considered in this study even though blood with RBCs is continuously flowing through the blood vessels. A spring network based on the DEM is employed to model the viscoelastic membrane of the RBC while the inside and outside fluid of RBC is modelled by SPH. The effect of the initial distance between two RBCs, membrane bending stiffness (Kb) of one RBC and undeformed diameter of one RBC on the motion and deformation of both RBCs in a uniform capillary is studied. Finally, the deformation behavior of two RBCs in a stenosed capillary is also examined. Simulation results reveal that the interaction between RBCs has significant influence on their motion and deformation.

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http://hdl.handle.net/10453/158959