Proximal Bone Remodeling in Lower Limb Amputees Reconstructed With an Osseointegrated Prosthesis.
- Publisher:
- WILEY
- Publication Type:
- Journal Article
- Citation:
- J Orthop Res, 2019, 37, (12), pp. 2524-2530
- Issue Date:
- 2019-12
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Journal Orthopaedic Research - 2019 - Thomson - Proximal Bone Remodeling in Lower Limb Amputees Reconstructed With an.pdf | Published version | 1.23 MB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Thomson, S | |
dc.contributor.author | Lu, W | |
dc.contributor.author | Zreiqat, H | |
dc.contributor.author | Li, JJ | |
dc.contributor.author | Tetsworth, K | |
dc.contributor.author | Al Muderis, M | |
dc.date.accessioned | 2022-07-22T02:45:02Z | |
dc.date.available | 2019-08-02 | |
dc.date.available | 2022-07-22T02:45:02Z | |
dc.date.issued | 2019-12 | |
dc.identifier.citation | J Orthop Res, 2019, 37, (12), pp. 2524-2530 | |
dc.identifier.issn | 0736-0266 | |
dc.identifier.issn | 1554-527X | |
dc.identifier.uri | http://hdl.handle.net/10453/159110 | |
dc.description.abstract | Mobility outcomes and changes in bone mineral density (BMD) of the spine and femoral necks in response to unilateral osseointegrated implants was investigated over a 3-year period. A total of 48 unilateral amputees who received an osseointegrated implant, comprising 33 trans-femoral amputees (TFA) and 15 trans-tibial amputees (TTA), underwent dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (L2-L4) and femoral necks at baseline, 1-, and 3-years follow-ups. Mobility outcomes, including the Six-Minute-Walk Test (6MWT) and Timed-Up-and-Go (TUG), were measured before surgery, at 1 year, and more than 2 years following the osseointegration procedure. We observed a significant increase (p < 0.05) in Z-score values in the femoral neck of the amputated side in TFA patients without a femoral neck lag screw at the 1- and 3-year follow-ups, as well as in TFA patients with a lag screw present at 3-year follow-up. The BMD at 1-year follow-up was found to be positively correlated with pre-surgery 6MWT values in patients who were mobile using a traditional socket prosthesis before receiving an osseointegrated implant. These results suggest that osseointegrated implants induce a physiological response in the femoral neck of recipients and appear to be evidence of restored biomechanical loading in the proximal femur. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2524-2530, 2019. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | WILEY | |
dc.relation.ispartof | J Orthop Res | |
dc.relation.isbasedon | 10.1002/jor.24445 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 0903 Biomedical Engineering, 1103 Clinical Sciences, 1106 Human Movement and Sports Sciences | |
dc.subject.classification | Orthopedics | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Amputees | |
dc.subject.mesh | Artificial Limbs | |
dc.subject.mesh | Bone Density | |
dc.subject.mesh | Bone Remodeling | |
dc.subject.mesh | Bone-Anchored Prosthesis | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lower Extremity | |
dc.subject.mesh | Male | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Lower Extremity | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Artificial Limbs | |
dc.subject.mesh | Bone Remodeling | |
dc.subject.mesh | Bone Density | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Aged | |
dc.subject.mesh | Middle Aged | |
dc.subject.mesh | Amputees | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Bone-Anchored Prosthesis | |
dc.title | Proximal Bone Remodeling in Lower Limb Amputees Reconstructed With an Osseointegrated Prosthesis. | |
dc.type | Journal Article | |
utslib.citation.volume | 37 | |
utslib.location.activity | United States | |
utslib.for | 0903 Biomedical Engineering | |
utslib.for | 1103 Clinical Sciences | |
utslib.for | 1106 Human Movement and Sports Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-07-22T02:44:58Z | |
pubs.issue | 12 | |
pubs.publication-status | Published | |
pubs.volume | 37 | |
utslib.citation.issue | 12 |
Abstract:
Mobility outcomes and changes in bone mineral density (BMD) of the spine and femoral necks in response to unilateral osseointegrated implants was investigated over a 3-year period. A total of 48 unilateral amputees who received an osseointegrated implant, comprising 33 trans-femoral amputees (TFA) and 15 trans-tibial amputees (TTA), underwent dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (L2-L4) and femoral necks at baseline, 1-, and 3-years follow-ups. Mobility outcomes, including the Six-Minute-Walk Test (6MWT) and Timed-Up-and-Go (TUG), were measured before surgery, at 1 year, and more than 2 years following the osseointegration procedure. We observed a significant increase (p < 0.05) in Z-score values in the femoral neck of the amputated side in TFA patients without a femoral neck lag screw at the 1- and 3-year follow-ups, as well as in TFA patients with a lag screw present at 3-year follow-up. The BMD at 1-year follow-up was found to be positively correlated with pre-surgery 6MWT values in patients who were mobile using a traditional socket prosthesis before receiving an osseointegrated implant. These results suggest that osseointegrated implants induce a physiological response in the femoral neck of recipients and appear to be evidence of restored biomechanical loading in the proximal femur. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:2524-2530, 2019.
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