The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health.

Mishra, GD; Chung, H-F; Pandeya, N; Dobson, AJ; Jones, L; Avis, NE; Crawford, SL; Gold, EB; Brown, D; Sievert, LL; Brunner, E; Cade, JE; Burley, VJ; Greenwood, DC; Giles, GG; Bruinsma, F; Goodman, A; Hayashi, K; Lee, JS; Mizunuma, H; Kuh, D; Cooper, R; Hardy, R; Obermeyer, CM; Lee, KA; Simonsen, MK; Yoshizawa, T; Woods, NF; Mitchell, ES; Hamer, M; Demakakos, P; Sandin, S; Adami, H-O; Weiderpass, E; Anderson, D

The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health.

Mishra, GD Chung, H-F Pandeya, N Dobson, AJ Jones, L Avis, NE Crawford, SL Gold, EB Brown, D Sievert, LL Brunner, E Cade, JE Burley, VJ Greenwood, DC Giles, GG Bruinsma, F Goodman, A Hayashi, K Lee, JS Mizunuma, H Kuh, D Cooper, R Hardy, R Obermeyer, CM Lee, KA Simonsen, MK Yoshizawa, T Woods, NF Mitchell, ES Hamer, M Demakakos, P Sandin, S Adami, H-O Weiderpass, E Anderson, D

Permalink

Publisher:: Elsevier BV
Publication Type:: Journal Article
Citation:: Maturitas, 2016, 92, pp. 176-185
Issue Date:: 2016-10

Closed Access

	Filename	Description	Size
	1-s2.0-S0378512216301839-main.pdf	Published version	887.4 kB		View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Mishra, GD
dc.contributor.author	Chung, H-F
dc.contributor.author	Pandeya, N
dc.contributor.author	Dobson, AJ
dc.contributor.author	Jones, L
dc.contributor.author	Avis, NE
dc.contributor.author	Crawford, SL
dc.contributor.author	Gold, EB
dc.contributor.author	Brown, D
dc.contributor.author	Sievert, LL
dc.contributor.author	Brunner, E
dc.contributor.author	Cade, JE
dc.contributor.author	Burley, VJ
dc.contributor.author	Greenwood, DC
dc.contributor.author	Giles, GG
dc.contributor.author	Bruinsma, F
dc.contributor.author	Goodman, A
dc.contributor.author	Hayashi, K
dc.contributor.author	Lee, JS
dc.contributor.author	Mizunuma, H
dc.contributor.author	Kuh, D
dc.contributor.author	Cooper, R
dc.contributor.author	Hardy, R
dc.contributor.author	Obermeyer, CM
dc.contributor.author	Lee, KA
dc.contributor.author	Simonsen, MK
dc.contributor.author	Yoshizawa, T
dc.contributor.author	Woods, NF
dc.contributor.author	Mitchell, ES
dc.contributor.author	Hamer, M
dc.contributor.author	Demakakos, P
dc.contributor.author	Sandin, S
dc.contributor.author	Adami, H-O
dc.contributor.author	Weiderpass, E
dc.contributor.author	Anderson, D https://orcid.org/0000-0001-8996-9624
dc.date.accessioned	2022-08-09T07:25:06Z
dc.date.available	2016-07-28
dc.date.available	2022-08-09T07:25:06Z
dc.date.issued	2016-10
dc.identifier.citation	Maturitas, 2016, 92, pp. 176-185
dc.identifier.issn	0378-5122
dc.identifier.issn	1873-4111
dc.identifier.uri	http://hdl.handle.net/10453/159812
dc.description.abstract	OBJECTIVES: The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. STUDY DESIGN: InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. MAIN OUTCOME MEASURES: Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). RESULTS: InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41-53), and that at the last follow-up was 56 years (IQR: 48-64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12-13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8-55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9-24.6%) and 5.1% (range 1.3-13.2%), respectively. CONCLUSIONS: The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier BV
dc.relation	http://purl.org/au-research/grants/nhmrc/1027196
dc.relation.ispartof	Maturitas
dc.relation.isbasedon	10.1016/j.maturitas.2016.07.021
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1114 Paediatrics and Reproductive Medicine
dc.subject.classification	Obstetrics & Reproductive Medicine
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Asians
dc.subject.mesh	Blacks
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Child
dc.subject.mesh	China
dc.subject.mesh	Chronic Disease
dc.subject.mesh	Cross-Cultural Comparison
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Diabetes Mellitus
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Japan
dc.subject.mesh	Latin America
dc.subject.mesh	Life Style
dc.subject.mesh	Menarche
dc.subject.mesh	Menopause
dc.subject.mesh	Middle Aged
dc.subject.mesh	Middle East
dc.subject.mesh	Observational Studies as Topic
dc.subject.mesh	Prevalence
dc.subject.mesh	Reproductive Health
dc.subject.mesh	Whites
dc.subject.mesh	Women's Health
dc.subject.mesh	Humans
dc.subject.mesh	Cardiovascular Diseases
dc.subject.mesh	Diabetes Mellitus
dc.subject.mesh	Chronic Disease
dc.subject.mesh	Prevalence
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Life Style
dc.subject.mesh	Menopause
dc.subject.mesh	Menarche
dc.subject.mesh	Cross-Cultural Comparison
dc.subject.mesh	Adolescent
dc.subject.mesh	Adult
dc.subject.mesh	Middle Aged
dc.subject.mesh	Child
dc.subject.mesh	Women's Health
dc.subject.mesh	Latin America
dc.subject.mesh	Middle East
dc.subject.mesh	China
dc.subject.mesh	Japan
dc.subject.mesh	Female
dc.subject.mesh	Reproductive Health
dc.subject.mesh	Observational Studies as Topic
dc.subject.mesh	Blacks
dc.subject.mesh	Asians
dc.subject.mesh	Whites
dc.title	The InterLACE study: Design, data harmonization and characteristics across 20 studies on women's health.
dc.type	Journal Article
utslib.citation.volume	92
utslib.location.activity	Ireland
utslib.for	1103 Clinical Sciences
utslib.for	1114 Paediatrics and Reproductive Medicine
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-09T07:25:05Z
pubs.publication-status	Published
pubs.volume	92

Abstract:

OBJECTIVES: The International Collaboration for a Life Course Approach to Reproductive Health and Chronic Disease Events (InterLACE) project is a global research collaboration that aims to advance understanding of women's reproductive health in relation to chronic disease risk by pooling individual participant data from several cohort and cross-sectional studies. The aim of this paper is to describe the characteristics of contributing studies and to present the distribution of demographic and reproductive factors and chronic disease outcomes in InterLACE. STUDY DESIGN: InterLACE is an individual-level pooled study of 20 observational studies (12 of which are longitudinal) from ten countries. Variables were harmonized across studies to create a new and systematic synthesis of life-course data. MAIN OUTCOME MEASURES: Harmonized data were derived in three domains: 1) socio-demographic and lifestyle factors, 2) female reproductive characteristics, and 3) chronic disease outcomes (cardiovascular disease (CVD) and diabetes). RESULTS: InterLACE pooled data from 229,054 mid-aged women. Overall, 76% of the women were Caucasian and 22% Japanese; other ethnicities (of 300 or more participants) included Hispanic/Latin American (0.2%), Chinese (0.2%), Middle Eastern (0.3%), African/black (0.5%), and Other (1.0%). The median age at baseline was 47 years (Inter-quartile range (IQR): 41-53), and that at the last follow-up was 56 years (IQR: 48-64). Regarding reproductive characteristics, half of the women (49.8%) had their first menstruation (menarche) at 12-13 years of age. The distribution of menopausal status and the prevalence of chronic disease varied considerably among studies. At baseline, most women (57%) were pre- or peri-menopausal, 20% reported a natural menopause (range 0.8-55.6%) and the remainder had surgery or were taking hormones. By the end of follow-up, the prevalence rates of CVD and diabetes were 7.2% (range 0.9-24.6%) and 5.1% (range 1.3-13.2%), respectively. CONCLUSIONS: The scale and heterogeneity of InterLACE data provide an opportunity to strengthen evidence concerning the relationships between reproductive health through life and subsequent risks of chronic disease, including cross-cultural comparisons.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/159812