Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.

Seib, C; Whiteside, E; Voisey, J; Lee, K; Alexander, K; Humphreys, J; Chopin, L; Anderson, D

Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.

Seib, C Whiteside, E Voisey, J Lee, K Alexander, K Humphreys, J Chopin, L Anderson, D

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Publisher:: Mary Ann Liebert Inc
Publication Type:: Journal Article
Citation:: Genet Test Mol Biomarkers, 2016, 20, (8), pp. 478-481
Issue Date:: 2016-08

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Field	Value	Language
dc.contributor.author	Seib, C
dc.contributor.author	Whiteside, E
dc.contributor.author	Voisey, J
dc.contributor.author	Lee, K
dc.contributor.author	Alexander, K
dc.contributor.author	Humphreys, J
dc.contributor.author	Chopin, L
dc.contributor.author	Anderson, D https://orcid.org/0000-0001-8996-9624
dc.date.accessioned	2022-08-09T07:43:19Z
dc.date.available	2022-08-09T07:43:19Z
dc.date.issued	2016-08
dc.identifier.citation	Genet Test Mol Biomarkers, 2016, 20, (8), pp. 478-481
dc.identifier.issn	1945-0265
dc.identifier.issn	1945-0257
dc.identifier.uri	http://hdl.handle.net/10453/159813
dc.description.abstract	OBJECTIVES: This exploratory study examined the association between exposure to stressful life events, polymorphisms (rs165774 and rs4680) in the catechol-O-methyltransferase (COMT) gene, and risk of depression in women. MATERIALS AND METHODS: A cross-sectional design gathered information from 150 Australia women, aged 60-70 years, on sociodemographics, stressful life events, and depressive symptoms. Participants also provided buccal cell swabs for genetic analysis. RESULTS: Among women exposed to stressful life events, the odds of depressive symptoms increased by 18% with each additional exposure (95% confidence interval [95% CI] 1.04-1.33, p = 0.007). Women who carried at least one "A" allele (AA/AG) for both rs165774 and rs4680 single nucleotide polymorphisms were less likely to report depressive symptoms (compared with women with the GG genotype; p = 0.019 and p = 0.037, respectively), although moderation analysis did not support the hypotheses of an interaction with stressful life events (rs165774: odds ratio [OR] = 1.13, 95% CI 0.87-1.46, p = 0.347; rs4680: OR = 1.15, 95% CI 0.91-1.44, p = 0.238). CONCLUSION: Our research suggests that women with polymorphisms in COMT were less susceptible to depressive symptoms but these polymorphisms do not appear to influence susceptibility to depression in those exposed to life stressors. Further research should consider other genetic variants in catecholamine pathways and their potential impact on women's mental health.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Mary Ann Liebert Inc
dc.relation.ispartof	Genet Test Mol Biomarkers
dc.relation.isbasedon	10.1089/gtmb.2015.0028
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0604 Genetics, 1103 Clinical Sciences
dc.subject.classification	Genetics & Heredity
dc.subject.mesh	Aged
dc.subject.mesh	Alleles
dc.subject.mesh	Australia
dc.subject.mesh	Catechol O-Methyltransferase
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Depression
dc.subject.mesh	Female
dc.subject.mesh	Gene Frequency
dc.subject.mesh	Genetic Association Studies
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Haplotypes
dc.subject.mesh	Humans
dc.subject.mesh	Middle Aged
dc.subject.mesh	Pilot Projects
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Humans
dc.subject.mesh	Genetic Predisposition to Disease
dc.subject.mesh	Catechol O-Methyltransferase
dc.subject.mesh	Cross-Sectional Studies
dc.subject.mesh	Pilot Projects
dc.subject.mesh	Depression
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Gene Frequency
dc.subject.mesh	Haplotypes
dc.subject.mesh	Polymorphism, Single Nucleotide
dc.subject.mesh	Alleles
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Australia
dc.subject.mesh	Female
dc.subject.mesh	Genetic Association Studies
dc.title	Stress, COMT Polymorphisms, and Depressive Symptoms in Older Australian Women: An Exploratory Study.
dc.type	Journal Article
utslib.citation.volume	20
utslib.location.activity	United States
utslib.for	0604 Genetics
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-09T07:43:18Z
pubs.issue	8
pubs.publication-status	Published
pubs.volume	20
utslib.citation.issue	8

Abstract:

OBJECTIVES: This exploratory study examined the association between exposure to stressful life events, polymorphisms (rs165774 and rs4680) in the catechol-O-methyltransferase (COMT) gene, and risk of depression in women. MATERIALS AND METHODS: A cross-sectional design gathered information from 150 Australia women, aged 60-70 years, on sociodemographics, stressful life events, and depressive symptoms. Participants also provided buccal cell swabs for genetic analysis. RESULTS: Among women exposed to stressful life events, the odds of depressive symptoms increased by 18% with each additional exposure (95% confidence interval [95% CI] 1.04-1.33, p = 0.007). Women who carried at least one "A" allele (AA/AG) for both rs165774 and rs4680 single nucleotide polymorphisms were less likely to report depressive symptoms (compared with women with the GG genotype; p = 0.019 and p = 0.037, respectively), although moderation analysis did not support the hypotheses of an interaction with stressful life events (rs165774: odds ratio [OR] = 1.13, 95% CI 0.87-1.46, p = 0.347; rs4680: OR = 1.15, 95% CI 0.91-1.44, p = 0.238). CONCLUSION: Our research suggests that women with polymorphisms in COMT were less susceptible to depressive symptoms but these polymorphisms do not appear to influence susceptibility to depression in those exposed to life stressors. Further research should consider other genetic variants in catecholamine pathways and their potential impact on women's mental health.

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http://hdl.handle.net/10453/159813