Novel bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility.

Chen, Y; Zhou, Y; Yang, S; Li, JJ; Li, X; Ma, Y; Hou, Y; Jiang, N; Xu, C; Zhang, S; Zeng, R; Tu, M; Yu, B

Novel bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility.

Chen, Y Zhou, Y Yang, S Li, JJ Li, X Ma, Y Hou, Y Jiang, N Xu, C Zhang, S Zeng, R Tu, M Yu, B

Permalink

Publisher:: ELSEVIER SCIENCE BV
Publication Type:: Journal Article
Citation:: Mater Sci Eng C Mater Biol Appl, 2016, 66, pp. 84-91
Issue Date:: 2016-09-01

Closed Access

	Filename	Description	Size
	1-s2.0-S0928493116303733-main.pdf	Published version	1.1 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Chen, Y
dc.contributor.author	Zhou, Y
dc.contributor.author	Yang, S
dc.contributor.author	Li, JJ
dc.contributor.author	Li, X
dc.contributor.author	Ma, Y
dc.contributor.author	Hou, Y
dc.contributor.author	Jiang, N
dc.contributor.author	Xu, C
dc.contributor.author	Zhang, S
dc.contributor.author	Zeng, R
dc.contributor.author	Tu, M
dc.contributor.author	Yu, B
dc.date.accessioned	2022-08-14T02:32:42Z
dc.date.available	2016-04-18
dc.date.available	2022-08-14T02:32:42Z
dc.date.issued	2016-09-01
dc.identifier.citation	Mater Sci Eng C Mater Biol Appl, 2016, 66, pp. 84-91
dc.identifier.issn	0928-4931
dc.identifier.issn	1873-0191
dc.identifier.uri	http://hdl.handle.net/10453/160118
dc.description.abstract	Calcium sulfate is in routine clinical use as a bone substitute, offering the benefits of biodegradability, biocompatibility and a long history of use in bone repair. The osteoconductive properties of calcium sulfate may be further improved by doping with strontium ions. Nevertheless, the high degradation rate of calcium sulfate may impede bone healing as substantial material degradation may occur before the healing process is complete. The purpose of this study is to develop a novel composite bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate in the form of microcapsules, which can promote osteogenesis while matching the natural rate of bone healing. The developed microcapsules exhibited controlled degradation that facilitated the sustained release of strontium ions. In vitro testing showed that the microcapsules had minimal cytotoxicity and ability to inhibit bacterial growth. In vivo testing in a mouse model showed the absence of genetic toxicity and low inflammatory potential of the microcapsules. The novel microcapsules developed in this study demonstrated suitable degradation characteristics for bone repair as well as favourable in vitro and in vivo behaviour, and hold promise for use as an alternative bone substitute in orthopaedic surgery.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE BV
dc.relation.ispartof	Mater Sci Eng C Mater Biol Appl
dc.relation.isbasedon	10.1016/j.msec.2016.04.070
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0903 Biomedical Engineering, 0912 Materials Engineering
dc.subject.classification	Biomedical Engineering
dc.subject.mesh	Animals
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Calcium Sulfate
dc.subject.mesh	Cell Line
dc.subject.mesh	Cell Survival
dc.subject.mesh	Chitosan
dc.subject.mesh	Escherichia coli
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Mice
dc.subject.mesh	Muscle, Skeletal
dc.subject.mesh	Prostheses and Implants
dc.subject.mesh	Rats
dc.subject.mesh	Strontium
dc.subject.mesh	Toxicity Tests
dc.subject.mesh	Muscle, Skeletal
dc.subject.mesh	Cell Line
dc.subject.mesh	Animals
dc.subject.mesh	Mice
dc.subject.mesh	Rats
dc.subject.mesh	Escherichia coli
dc.subject.mesh	Calcium Sulfate
dc.subject.mesh	Strontium
dc.subject.mesh	Chitosan
dc.subject.mesh	Biocompatible Materials
dc.subject.mesh	Bone Substitutes
dc.subject.mesh	Anti-Bacterial Agents
dc.subject.mesh	Toxicity Tests
dc.subject.mesh	Prostheses and Implants
dc.subject.mesh	Cell Survival
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.title	Novel bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate: Fabrication, characterisation and evaluation of biocompatibility.
dc.type	Journal Article
utslib.citation.volume	66
utslib.location.activity	Netherlands
utslib.for	0903 Biomedical Engineering
utslib.for	0912 Materials Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-14T02:32:41Z
pubs.publication-status	Published
pubs.volume	66

Abstract:

Calcium sulfate is in routine clinical use as a bone substitute, offering the benefits of biodegradability, biocompatibility and a long history of use in bone repair. The osteoconductive properties of calcium sulfate may be further improved by doping with strontium ions. Nevertheless, the high degradation rate of calcium sulfate may impede bone healing as substantial material degradation may occur before the healing process is complete. The purpose of this study is to develop a novel composite bone substitute composed of chitosan and strontium-doped α-calcium sulfate hemihydrate in the form of microcapsules, which can promote osteogenesis while matching the natural rate of bone healing. The developed microcapsules exhibited controlled degradation that facilitated the sustained release of strontium ions. In vitro testing showed that the microcapsules had minimal cytotoxicity and ability to inhibit bacterial growth. In vivo testing in a mouse model showed the absence of genetic toxicity and low inflammatory potential of the microcapsules. The novel microcapsules developed in this study demonstrated suitable degradation characteristics for bone repair as well as favourable in vitro and in vivo behaviour, and hold promise for use as an alternative bone substitute in orthopaedic surgery.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160118