Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression.

Chang, L; Ni, J; Zhu, Y; Pang, B; Graham, P; Zhang, H; Li, Y

Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression.

Chang, L Ni, J Zhu, Y

Pang, B Graham, P Zhang, H Li, Y

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Publisher:: Ivyspring International Publisher
Publication Type:: Journal Article
Citation:: Theranostics, 2019, 9, (14), pp. 4130-4140
Issue Date:: 2019

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Field	Value	Language
dc.contributor.author	Chang, L
dc.contributor.author	Ni, J
dc.contributor.author	Zhu, Y https://orcid.org/0000-0002-8840-176X
dc.contributor.author	Pang, B
dc.contributor.author	Graham, P
dc.contributor.author	Zhang, H
dc.contributor.author	Li, Y
dc.date.accessioned	2022-08-15T01:33:12Z
dc.date.available	2019-05-01
dc.date.available	2022-08-15T01:33:12Z
dc.date.issued	2019
dc.identifier.citation	Theranostics, 2019, 9, (14), pp. 4130-4140
dc.identifier.issn	1838-7640
dc.identifier.issn	1838-7640
dc.identifier.uri	http://hdl.handle.net/10453/160168
dc.description.abstract	The current biomarkers available in the clinic are not enough for early diagnosis or for monitoring disease progression of ovarian cancer. Liquid biopsy is a minimally invasive test and has the advantage of early diagnosis and real-time monitoring of treatment response. Although significant progress has been made in the usage of circulating tumor cells and cell-free DNA for ovarian cancer diagnosis, their potential for early detection or monitoring progression remains elusive. Extracellular vesicles (EVs) are a heterogeneous group of lipid membranous particles released from almost all cell types. EVs contain proteins, mRNA, DNA fragments, non-coding RNAs, and lipids and play a critical role in intercellular communication. Emerging evidence suggests that EVs have crucial roles in cancer development and metastasis, thus holding promise for liquid biopsy-based biomarker discovery for ovarian cancer diagnosis. In this review, we discuss the advantages of EV-based liquid biopsy, summarize the protein biomarkers identified from EVs in ovarian cancer, and highlight the utility of new technologies recently developed for EV detection with an emphasis on their use for diagnosing ovarian cancer, monitoring cancer progression, and developing personalized medicine.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Ivyspring International Publisher
dc.relation.ispartof	Theranostics
dc.relation.isbasedon	10.7150/thno.34692
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	1112 Oncology and Carcinogenesis
dc.subject.mesh	Early Detection of Cancer
dc.subject.mesh	Extracellular Vesicles
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Liquid Biopsy
dc.subject.mesh	Ovarian Neoplasms
dc.subject.mesh	RNA, Messenger
dc.subject.mesh	Early Detection of Cancer
dc.subject.mesh	Extracellular Vesicles
dc.subject.mesh	Female
dc.subject.mesh	Humans
dc.subject.mesh	Liquid Biopsy
dc.subject.mesh	Ovarian Neoplasms
dc.subject.mesh	RNA, Messenger
dc.subject.mesh	Humans
dc.subject.mesh	Ovarian Neoplasms
dc.subject.mesh	RNA, Messenger
dc.subject.mesh	Female
dc.subject.mesh	Early Detection of Cancer
dc.subject.mesh	Extracellular Vesicles
dc.subject.mesh	Liquid Biopsy
dc.title	Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	Australia
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-08-15T01:32:56Z
pubs.issue	14
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	14

Abstract:

The current biomarkers available in the clinic are not enough for early diagnosis or for monitoring disease progression of ovarian cancer. Liquid biopsy is a minimally invasive test and has the advantage of early diagnosis and real-time monitoring of treatment response. Although significant progress has been made in the usage of circulating tumor cells and cell-free DNA for ovarian cancer diagnosis, their potential for early detection or monitoring progression remains elusive. Extracellular vesicles (EVs) are a heterogeneous group of lipid membranous particles released from almost all cell types. EVs contain proteins, mRNA, DNA fragments, non-coding RNAs, and lipids and play a critical role in intercellular communication. Emerging evidence suggests that EVs have crucial roles in cancer development and metastasis, thus holding promise for liquid biopsy-based biomarker discovery for ovarian cancer diagnosis. In this review, we discuss the advantages of EV-based liquid biopsy, summarize the protein biomarkers identified from EVs in ovarian cancer, and highlight the utility of new technologies recently developed for EV detection with an emphasis on their use for diagnosing ovarian cancer, monitoring cancer progression, and developing personalized medicine.

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http://hdl.handle.net/10453/160168