Fructose-Coated Nanodiamonds: Promising Platforms for Treatment of Human Breast Cancer
- Publisher:
- AMER CHEMICAL SOC
- Publication Type:
- Journal Article
- Citation:
- Biomacromolecules, 2016, 17, (9), pp. 2946-2955
- Issue Date:
- 2016
Closed Access
Filename | Description | Size | |||
---|---|---|---|---|---|
acs.biomac.6b00754.pdf | Published version | 6.88 MB | Adobe PDF |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Zhao, JC | |
dc.contributor.author | Lai, HW | |
dc.contributor.author | Lu, HX | |
dc.contributor.author | Barner-Kowollik, C | |
dc.contributor.author | Stenzel, MH | |
dc.contributor.author | Xiao, P | |
dc.date.accessioned | 2022-08-20T22:09:13Z | |
dc.date.available | 2022-08-20T22:09:13Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Biomacromolecules, 2016, 17, (9), pp. 2946-2955 | |
dc.identifier.issn | 1525-7797 | |
dc.identifier.issn | 1526-4602 | |
dc.identifier.uri | http://hdl.handle.net/10453/160586 | |
dc.description.abstract | Well-defined carboxyl end-functionalized glycopolymer Poly(1-O-methacryloyl-2,3:4,5-di-O-isopropylidene-β-d-fructopyranose) (Poly(1-O-MAipFru)62) has been prepared via reversible addition-fragmentation chain transfer polymerization and grafted onto the surface of amine-functionalized nanodiamonds via a simple conjugation reaction. The properties of the nanodiamond-polymer hybrid materials ND-Poly(1-O-MAFru)62 are investigated using infrared spectroscopy, thermogravimetric analysis, dynamic light scattering, and transmission electron microscopy. The dispersibility of the nanodiamonds in aqueous solutions is significantly improved after the grafting of the glycopolymer. More interestingly, the cytotoxicity of amine-functionalized nanodiamonds is significantly decreased after decoration with the glycopolymer even at a high concentration (125 μg/mL). The nanodiamonds were loaded with doxorubicin to create a bioactive drug delivery carrier. The release of doxorubicin was faster in media of pH 5 than media of pH 7.4. The nanodiamond drug delivery systems with doxorubicin are used to treat breast cancer cells in 2D and 3D models. Although the 2D cell culture results indicate that all nanodiamonds-doxorubicin complexes are significantly less toxic than free doxorubicin, the glycopolymer-coated nanodiamonds-doxorubicin show higher cytotoxicity than free doxorubicin in the 3D spheroids after treatment for 8 days. The enhanced cytotoxicity of Poly(1-O-MAFru)62-ND-Dox in 3D spheroids may result from the sustained drug release and deep penetration of these nanocarriers, which play a role as a "Trojan Horse". The massive cell death after 8-day incubation with Poly(1-O-MAFru)62-ND-Dox demonstrates that glycopolymer-coated nanodiamonds can be promising platforms for breast cancer therapy. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | AMER CHEMICAL SOC | |
dc.relation.ispartof | Biomacromolecules | |
dc.relation.isbasedon | 10.1021/acs.biomac.6b00754 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 03 Chemical Sciences, 06 Biological Sciences, 09 Engineering | |
dc.subject.classification | Polymers | |
dc.subject.mesh | Antibiotics, Antineoplastic | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Doxorubicin | |
dc.subject.mesh | Drug Delivery Systems | |
dc.subject.mesh | Drug Liberation | |
dc.subject.mesh | Female | |
dc.subject.mesh | Fructose | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Nanodiamonds | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Spheroids, Cellular | |
dc.subject.mesh | Tumor Cells, Cultured | |
dc.subject.mesh | Spheroids, Cellular | |
dc.subject.mesh | Tumor Cells, Cultured | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Breast Neoplasms | |
dc.subject.mesh | Doxorubicin | |
dc.subject.mesh | Polymers | |
dc.subject.mesh | Fructose | |
dc.subject.mesh | Antibiotics, Antineoplastic | |
dc.subject.mesh | Drug Delivery Systems | |
dc.subject.mesh | Cell Survival | |
dc.subject.mesh | Female | |
dc.subject.mesh | Nanodiamonds | |
dc.subject.mesh | Drug Liberation | |
dc.title | Fructose-Coated Nanodiamonds: Promising Platforms for Treatment of Human Breast Cancer | |
dc.type | Journal Article | |
utslib.citation.volume | 17 | |
utslib.location.activity | United States | |
utslib.for | 03 Chemical Sciences | |
utslib.for | 06 Biological Sciences | |
utslib.for | 09 Engineering | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering | |
pubs.organisational-group | /University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2022-08-20T22:09:08Z | |
pubs.issue | 9 | |
pubs.publication-status | Published | |
pubs.volume | 17 | |
utslib.citation.issue | 9 |
Abstract:
Well-defined carboxyl end-functionalized glycopolymer Poly(1-O-methacryloyl-2,3:4,5-di-O-isopropylidene-β-d-fructopyranose) (Poly(1-O-MAipFru)62) has been prepared via reversible addition-fragmentation chain transfer polymerization and grafted onto the surface of amine-functionalized nanodiamonds via a simple conjugation reaction. The properties of the nanodiamond-polymer hybrid materials ND-Poly(1-O-MAFru)62 are investigated using infrared spectroscopy, thermogravimetric analysis, dynamic light scattering, and transmission electron microscopy. The dispersibility of the nanodiamonds in aqueous solutions is significantly improved after the grafting of the glycopolymer. More interestingly, the cytotoxicity of amine-functionalized nanodiamonds is significantly decreased after decoration with the glycopolymer even at a high concentration (125 μg/mL). The nanodiamonds were loaded with doxorubicin to create a bioactive drug delivery carrier. The release of doxorubicin was faster in media of pH 5 than media of pH 7.4. The nanodiamond drug delivery systems with doxorubicin are used to treat breast cancer cells in 2D and 3D models. Although the 2D cell culture results indicate that all nanodiamonds-doxorubicin complexes are significantly less toxic than free doxorubicin, the glycopolymer-coated nanodiamonds-doxorubicin show higher cytotoxicity than free doxorubicin in the 3D spheroids after treatment for 8 days. The enhanced cytotoxicity of Poly(1-O-MAFru)62-ND-Dox in 3D spheroids may result from the sustained drug release and deep penetration of these nanocarriers, which play a role as a "Trojan Horse". The massive cell death after 8-day incubation with Poly(1-O-MAFru)62-ND-Dox demonstrates that glycopolymer-coated nanodiamonds can be promising platforms for breast cancer therapy.
Please use this identifier to cite or link to this item:
Download statistics for the last 12 months
Not enough data to produce graph