PEG Grafted-Nanodiamonds for the Delivery of Gemcitabine.

Lu, M; Wang, Y-K; Zhao, J; Lu, H; Stenzel, MH; Xiao, P

PEG Grafted-Nanodiamonds for the Delivery of Gemcitabine.

Lu, M Wang, Y-K Zhao, J Lu, H

Stenzel, MH Xiao, P

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Publisher:: WILEY-V C H VERLAG GMBH
Publication Type:: Journal Article
Citation:: Macromol Rapid Commun, 2016, 37, (24), pp. 2023-2029
Issue Date:: 2016-12

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Field	Value	Language
dc.contributor.author	Lu, M
dc.contributor.author	Wang, Y-K
dc.contributor.author	Zhao, J
dc.contributor.author	Lu, H https://orcid.org/0000-0001-6932-1900
dc.contributor.author	Stenzel, MH
dc.contributor.author	Xiao, P
dc.date.accessioned	2022-08-21T21:45:30Z
dc.date.available	2022-08-21T21:45:30Z
dc.date.issued	2016-12
dc.identifier.citation	Macromol Rapid Commun, 2016, 37, (24), pp. 2023-2029
dc.identifier.issn	1022-1336
dc.identifier.issn	1521-3927
dc.identifier.uri	http://hdl.handle.net/10453/160619
dc.description.abstract	Carboxyl end-functionalized poly[poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)] and its block copolymer with gemcitabine substituted poly(N-hydroxysuccinimide methacrylate) [PGem-block-P(PEGMEMA)] are synthesized via reversible addition-fragmentation transfer (RAFT) polymerization. Then, two polymers are grafted onto the surface of amine-functionalized nanodiamonds to obtain [P(PEGMEMA)]-grafted nanodiamonds (ND-PEG) and [PGem-block-P(PEGMEMA)]-grafted nanodiamonds (ND-PF). Gemcitabine is physically absorbed to ND-PEG to produce ND-PEG (Gem). Two polymer-grafted nanodiamonds (i.e., with physically absorbed gemcitabine ND-PEG (Gem) and with chemically conjugated gemcitabine ND-PF) are characterized using attenuated total reflectance infrared spectroscopy, dynamic light scattering, and thermogravimetric analysis. The drug release, cytotoxicity (to seed human pancreatic carcinoma AsPC-1 cells), and cellular uptake of ND-PEG (Gem) and ND-PF are also investigated.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	WILEY-V C H VERLAG GMBH
dc.relation.ispartof	Macromol Rapid Commun
dc.relation.isbasedon	10.1002/marc.201600344
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.subject.classification	Polymers
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Deoxycytidine
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Humans
dc.subject.mesh	Nanodiamonds
dc.subject.mesh	Pancreatic Neoplasms
dc.subject.mesh	Polyethylene Glycols
dc.subject.mesh	Cell Line, Tumor
dc.subject.mesh	Humans
dc.subject.mesh	Pancreatic Neoplasms
dc.subject.mesh	Polyethylene Glycols
dc.subject.mesh	Deoxycytidine
dc.subject.mesh	Drug Delivery Systems
dc.subject.mesh	Nanodiamonds
dc.title	PEG Grafted-Nanodiamonds for the Delivery of Gemcitabine.
dc.type	Journal Article
utslib.citation.volume	37
utslib.location.activity	Germany
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	in_progress	*
dc.date.updated	2022-08-21T21:45:29Z
pubs.issue	24
pubs.publication-status	Published
pubs.volume	37
utslib.citation.issue	24

Abstract:

Carboxyl end-functionalized poly[poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)] and its block copolymer with gemcitabine substituted poly(N-hydroxysuccinimide methacrylate) [PGem-block-P(PEGMEMA)] are synthesized via reversible addition-fragmentation transfer (RAFT) polymerization. Then, two polymers are grafted onto the surface of amine-functionalized nanodiamonds to obtain [P(PEGMEMA)]-grafted nanodiamonds (ND-PEG) and [PGem-block-P(PEGMEMA)]-grafted nanodiamonds (ND-PF). Gemcitabine is physically absorbed to ND-PEG to produce ND-PEG (Gem). Two polymer-grafted nanodiamonds (i.e., with physically absorbed gemcitabine ND-PEG (Gem) and with chemically conjugated gemcitabine ND-PF) are characterized using attenuated total reflectance infrared spectroscopy, dynamic light scattering, and thermogravimetric analysis. The drug release, cytotoxicity (to seed human pancreatic carcinoma AsPC-1 cells), and cellular uptake of ND-PEG (Gem) and ND-PF are also investigated.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160619