Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants

Karacan, I; Chou, J; Ben-Nissan, B; Macha, I; Cazalbou, S; Milthorpe, B

Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants

Karacan, I Chou, J

Ben-Nissan, B Macha, I Cazalbou, S Milthorpe, B

Permalink

Publisher:: Trans Tech Publications, Ltd.
Publication Type:: Journal Article
Citation:: Key Engineering Materials, 2018, 782 KEM, pp. 212-217
Issue Date:: 2018-01-01

Closed Access

	Filename	Description	Size
	out (4).pdf	Published version	3.79 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Karacan, I
dc.contributor.author	Chou, J https://orcid.org/0000-0002-7472-8016
dc.contributor.author	Ben-Nissan, B
dc.contributor.author	Macha, I
dc.contributor.author	Cazalbou, S
dc.contributor.author	Milthorpe, B https://orcid.org/0000-0002-0867-9586
dc.date.accessioned	2022-08-22T21:47:53Z
dc.date.available	2022-08-22T21:47:53Z
dc.date.issued	2018-01-01
dc.identifier.citation	Key Engineering Materials, 2018, 782 KEM, pp. 212-217
dc.identifier.issn	1013-9826
dc.identifier.issn	1662-9795
dc.identifier.uri	http://hdl.handle.net/10453/160699
dc.description.abstract	The new novel implant designs include the functionality of advanced drug delivery systems in order to improve osteointegration and to inhibit the implant-related post-operative infections. In this research, Ti6Al4V metallic implants were coated with the multifunctional-dual slow drug delivery coating which includes a polymeric matrix system based on a poly-lactic acid thin film and bioactive ceramic hydroxyapatite. This system consists of two different kinds of pharmaceuticals, which are gentamicin and simvastatin. It is reported in this paper that the simvastatin and gentamicin containing poly-lactic acid coating which was applied uniformly and successfully with and without hydroxyapatite microspheres. Most importantly, the release rate of drugs was controlled with poly-lactic acid matrix and hydroxyapatite microspheres which have different dissolution rates in order to prevent the high dosages causing adverse side-effects of drugs.
dc.language	en
dc.publisher	Trans Tech Publications, Ltd.
dc.relation.ispartof	Key Engineering Materials
dc.relation.isbasedon	10.4028/www.scientific.net/KEM.782.212
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	09 Engineering
dc.subject.classification	Materials
dc.title	Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants
dc.type	Journal Article
utslib.citation.volume	782 KEM
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	closed_access	*
dc.date.updated	2022-08-22T21:47:50Z
pubs.publication-status	Published
pubs.volume	782 KEM

Abstract:

The new novel implant designs include the functionality of advanced drug delivery systems in order to improve osteointegration and to inhibit the implant-related post-operative infections. In this research, Ti6Al4V metallic implants were coated with the multifunctional-dual slow drug delivery coating which includes a polymeric matrix system based on a poly-lactic acid thin film and bioactive ceramic hydroxyapatite. This system consists of two different kinds of pharmaceuticals, which are gentamicin and simvastatin. It is reported in this paper that the simvastatin and gentamicin containing poly-lactic acid coating which was applied uniformly and successfully with and without hydroxyapatite microspheres. Most importantly, the release rate of drugs was controlled with poly-lactic acid matrix and hydroxyapatite microspheres which have different dissolution rates in order to prevent the high dosages causing adverse side-effects of drugs.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/160699