Mutations in Hepatitis-B X-Gene Region: Chronic Hepatitis-B versus Cirrhosis.
- Publisher:
- Dr. Hemant Jain and Premchand Shantidevi Research foundation
- Publication Type:
- Journal Article
- Citation:
- Journal of Clinical and Diagnostic Research, 2017, 11, (3), pp. OC31-OC34
- Issue Date:
- 2017-03
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22570_CE[Ra1]_F(GH)_PF1(P_RK)_PFA(RK)_PF2(NE_SY_DK).pdf | 76.61 kB |
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INTRODUCTION: Specific mutations in Hepatitis-B Virus (HBV) genome would proceed the development of chronic hepatitis B to more serious consequences like cirrhosis and end-stage liver disease. AIM: This study was designed to detect deletion and insertion mutational patterns in the X-gene region in a population of chronic HBV and related cirrhosis patients. MATERIALS AND METHODS: Sixty eight chronic HBV patients and 34 HBV-related cirrhotics were recruited from the eligible cases (N=50) referred to the academic hospitals of Gorgan city, Northeast of Iran, between Jan 2011 to Dec 2013. The HBx region was amplified by semi-nested PCR using serum samples and analyzed by sequencing. RESULTS: Our findings showed deletions and insertions in the C-terminal of HBx of the cirrhotic group and 8 bp found in two chronic HBV cases (2.9%). We detected 15 types of deletions in cirrhotic cases such as 1762-1768, 1763-1770, 1769-1773 and T1771/A1775. CONCLUSION: We found that the frequencies of deletion and insertion mutations in C-terminal of X-gene were more seen in cirrhotic patients comparing to chronic HBV cases in our area of study.
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