Cost-Effective Double-Layer Hydrogel Composites for Wound Dressing Applications.

Tavakoli, J; Mirzaei, S; Tang, Y

Cost-Effective Double-Layer Hydrogel Composites for Wound Dressing Applications.

Tavakoli, J

Mirzaei, S Tang, Y

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Publisher:: MDPI
Publication Type:: Journal Article
Citation:: Polymers (Basel), 2018, 10, (3), pp. E305
Issue Date:: 2018-03-12

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Field	Value	Language
dc.contributor.author	Tavakoli, J https://orcid.org/0000-0002-0696-6530
dc.contributor.author	Mirzaei, S
dc.contributor.author	Tang, Y
dc.date.accessioned	2022-09-05T20:55:24Z
dc.date.available	2018-03-08
dc.date.available	2022-09-05T20:55:24Z
dc.date.issued	2018-03-12
dc.identifier.citation	Polymers (Basel), 2018, 10, (3), pp. E305
dc.identifier.issn	2073-4360
dc.identifier.issn	2073-4360
dc.identifier.uri	http://hdl.handle.net/10453/161377
dc.description.abstract	Although poly vinyl alcohol-poly acrylic acid (PVA-PAA) composites have been widely used for biomedical applications, their incorporation into double-layer assembled thin films has been limited because the interfacial binding materials negatively influence the water uptake capacity of PVA. To minimize the effect of interfacial binding, a simple method for the fabrication of a double-layered PVA-PAA hydrogel was introduced, and its biomedical properties were evaluated in this study. Our results revealed that the addition of PAA layers on the surface of PVA significantly increased the swelling properties. Compared to PVA, the equilibrium swelling ratio of the PVA-PAA hydrogel increased (p = 0.035) and its water vapour permeability significantly decreased (p = 0.04). Statistical analysis revealed that an increase in pH value from 7 to 10 as well as the addition of PAA at pH = 7 significantly increased the adhesion force (p < 0.04). The mechanical properties-including ultimate tensile strength, modulus, and elongation at break-remained approximately untouched compared to PVA. A significant increase in biocompatibility was found after day 7 (p = 0.016). A higher release rate for tetracycline was found at pH = 8 compared to neutral pH.
dc.format	Electronic
dc.language	eng
dc.publisher	MDPI
dc.relation.ispartof	Polymers (Basel)
dc.relation.isbasedon	10.3390/polym10030305
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.title	Cost-Effective Double-Layer Hydrogel Composites for Wound Dressing Applications.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	Switzerland
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
utslib.copyright.status	open_access	*
dc.date.updated	2022-09-05T20:55:20Z
pubs.issue	3
pubs.publication-status	Published online
pubs.volume	10
utslib.citation.issue	3

Abstract:

Although poly vinyl alcohol-poly acrylic acid (PVA-PAA) composites have been widely used for biomedical applications, their incorporation into double-layer assembled thin films has been limited because the interfacial binding materials negatively influence the water uptake capacity of PVA. To minimize the effect of interfacial binding, a simple method for the fabrication of a double-layered PVA-PAA hydrogel was introduced, and its biomedical properties were evaluated in this study. Our results revealed that the addition of PAA layers on the surface of PVA significantly increased the swelling properties. Compared to PVA, the equilibrium swelling ratio of the PVA-PAA hydrogel increased (p = 0.035) and its water vapour permeability significantly decreased (p = 0.04). Statistical analysis revealed that an increase in pH value from 7 to 10 as well as the addition of PAA at pH = 7 significantly increased the adhesion force (p < 0.04). The mechanical properties-including ultimate tensile strength, modulus, and elongation at break-remained approximately untouched compared to PVA. A significant increase in biocompatibility was found after day 7 (p = 0.016). A higher release rate for tetracycline was found at pH = 8 compared to neutral pH.

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http://hdl.handle.net/10453/161377