Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation.

Deng, W; Chen, W; Clement, S; Guller, A; Zhao, Z; Engel, A; Goldys, EM

Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation.

Deng, W

Chen, W Clement, S Guller, A Zhao, Z Engel, A Goldys, EM

Permalink

Publisher:: NATURE PUBLISHING GROUP
Publication Type:: Journal Article
Citation:: Nat Commun, 2018, 9, (1), pp. 2713
Issue Date:: 2018-07-13

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download Published versionAdobe PDF (2.07 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Deng, W https://orcid.org/0000-0002-9413-0978
dc.contributor.author	Chen, W
dc.contributor.author	Clement, S
dc.contributor.author	Guller, A
dc.contributor.author	Zhao, Z
dc.contributor.author	Engel, A
dc.contributor.author	Goldys, EM
dc.date.accessioned	2022-09-08T01:47:52Z
dc.date.available	2018-05-24
dc.date.available	2022-09-08T01:47:52Z
dc.date.issued	2018-07-13
dc.identifier.citation	Nat Commun, 2018, 9, (1), pp. 2713
dc.identifier.issn	2041-1723
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10453/161515
dc.description.abstract	Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.
dc.format	Electronic
dc.language	eng
dc.publisher	NATURE PUBLISHING GROUP
dc.relation	http://purl.org/au-research/grants/arc/DE130100894
dc.relation	http://purl.org/au-research/grants/arc/CE140100003
dc.relation.ispartof	Nat Commun
dc.relation.isbasedon	10.1038/s41467-018-05118-3
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Colonic Neoplasms
dc.subject.mesh	Combined Modality Therapy
dc.subject.mesh	Delayed-Action Preparations
dc.subject.mesh	Doxorubicin
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Etoposide
dc.subject.mesh	Fluoresceins
dc.subject.mesh	Folic Acid
dc.subject.mesh	Gene Silencing
dc.subject.mesh	Gold
dc.subject.mesh	HCT116 Cells
dc.subject.mesh	Humans
dc.subject.mesh	Liposomes
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Mice
dc.subject.mesh	Oligoribonucleotides, Antisense
dc.subject.mesh	PC12 Cells
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Photosensitizing Agents
dc.subject.mesh	Rats
dc.subject.mesh	Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
dc.subject.mesh	Singlet Oxygen
dc.subject.mesh	Verteporfin
dc.subject.mesh	X-Rays
dc.subject.mesh	Xenograft Model Antitumor Assays
dc.subject.mesh	HCT116 Cells
dc.subject.mesh	PC12 Cells
dc.subject.mesh	Animals
dc.subject.mesh	Humans
dc.subject.mesh	Mice
dc.subject.mesh	Rats
dc.subject.mesh	Colonic Neoplasms
dc.subject.mesh	Gold
dc.subject.mesh	Singlet Oxygen
dc.subject.mesh	Folic Acid
dc.subject.mesh	Fluoresceins
dc.subject.mesh	Doxorubicin
dc.subject.mesh	Etoposide
dc.subject.mesh	Oligoribonucleotides, Antisense
dc.subject.mesh	Antineoplastic Agents
dc.subject.mesh	Photosensitizing Agents
dc.subject.mesh	Liposomes
dc.subject.mesh	Delayed-Action Preparations
dc.subject.mesh	Combined Modality Therapy
dc.subject.mesh	Photochemotherapy
dc.subject.mesh	Xenograft Model Antitumor Assays
dc.subject.mesh	Gene Silencing
dc.subject.mesh	X-Rays
dc.subject.mesh	Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I
dc.subject.mesh	Metal Nanoparticles
dc.subject.mesh	Drug Liberation
dc.subject.mesh	Verteporfin
dc.title	Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2022-09-08T01:47:47Z
pubs.issue	1
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	1

Abstract:

Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes incorporating gold nanoparticles and photosensitizer verteporfin. The 6 MeV X-ray radiation induces verteporfin to produce singlet oxygen, which destabilises the liposomal membrane and causes the release of cargos from the liposomal cavity. This triggering strategy is demonstrated by the efficiency of gene silencing in vitro and increased effectiveness of chemotherapy in vivo. Our work indicates the feasibility of a combinatorial treatment and possible synergistic effects in the course of standard radiotherapy combined with chemotherapy delivered via X-ray-triggered liposomes. Importantly, our X-ray-mediated liposome release strategy offers prospects for deep tissue photodynamic therapy, by removing its depth limitation.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161515