Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.

Tong, JY; Viswanathan, D; Hodge, C; Sutton, G; Chan, C; Males, JJ

Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.

Tong, JY Viswanathan, D Hodge, C

Sutton, G Chan, C Males, JJ

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Publisher:: Asia Pacific Academy of Ophthalmology
Publication Type:: Journal Article
Citation:: Asia - Pacific Journal of Ophthalmology, 2017, 6, (3), pp. 228-232
Issue Date:: 2017-05

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Field	Value	Language
dc.contributor.author	Tong, JY
dc.contributor.author	Viswanathan, D
dc.contributor.author	Hodge, C https://orcid.org/0000-0002-0516-6486
dc.contributor.author	Sutton, G
dc.contributor.author	Chan, C
dc.contributor.author	Males, JJ
dc.date.accessioned	2022-09-09T05:26:59Z
dc.date.available	2022-09-09T05:26:59Z
dc.date.issued	2017-05
dc.identifier.citation	Asia - Pacific Journal of Ophthalmology, 2017, 6, (3), pp. 228-232
dc.identifier.issn	0129-1653
dc.identifier.issn	2162-0989
dc.identifier.uri	http://hdl.handle.net/10453/161583
dc.description.abstract	PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia. METHODS: Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis. RESULTS: At last follow-up, BSCVA improved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed. CONCLUSIONS: In the Australian setting, CXL has proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Asia Pacific Academy of Ophthalmology
dc.relation.ispartof	Asia - Pacific Journal of Ophthalmology
dc.relation.isbasedon	10.22608/APO.2016197
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1113 Opthalmology and Optometry
dc.subject.mesh	Adult
dc.subject.mesh	Collagen
dc.subject.mesh	Cornea
dc.subject.mesh	Corneal Diseases
dc.subject.mesh	Corneal Topography
dc.subject.mesh	Cross-Linking Reagents
dc.subject.mesh	Dilatation, Pathologic
dc.subject.mesh	Female
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Humans
dc.subject.mesh	Keratomileusis, Laser In Situ
dc.subject.mesh	Male
dc.subject.mesh	Myopia
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Postoperative Period
dc.subject.mesh	Refraction, Ocular
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Adult
dc.subject.mesh	Collagen
dc.subject.mesh	Cornea
dc.subject.mesh	Corneal Diseases
dc.subject.mesh	Corneal Topography
dc.subject.mesh	Cross-Linking Reagents
dc.subject.mesh	Dilatation, Pathologic
dc.subject.mesh	Female
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Humans
dc.subject.mesh	Keratomileusis, Laser In Situ
dc.subject.mesh	Male
dc.subject.mesh	Myopia
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Postoperative Period
dc.subject.mesh	Refraction, Ocular
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Cornea
dc.subject.mesh	Humans
dc.subject.mesh	Corneal Diseases
dc.subject.mesh	Myopia
dc.subject.mesh	Dilatation, Pathologic
dc.subject.mesh	Postoperative Complications
dc.subject.mesh	Collagen
dc.subject.mesh	Cross-Linking Reagents
dc.subject.mesh	Corneal Topography
dc.subject.mesh	Refraction, Ocular
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Keratomileusis, Laser In Situ
dc.subject.mesh	Postoperative Period
dc.subject.mesh	Retrospective Studies
dc.subject.mesh	Follow-Up Studies
dc.subject.mesh	Adult
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.title	Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.
dc.type	Journal Article
utslib.citation.volume	6
utslib.location.activity	China
utslib.for	1113 Opthalmology and Optometry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-09-09T05:26:58Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	6
utslib.citation.issue	3

Abstract:

PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia. METHODS: Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis. RESULTS: At last follow-up, BSCVA improved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed. CONCLUSIONS: In the Australian setting, CXL has proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/161583