Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.
- Publisher:
- Asia Pacific Academy of Ophthalmology
- Publication Type:
- Journal Article
- Citation:
- Asia - Pacific Journal of Ophthalmology, 2017, 6, (3), pp. 228-232
- Issue Date:
- 2017-05
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Corneal_Collagen_Crosslinking_for_Post_LASIK.2.pdf | 999.54 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Tong, JY | |
dc.contributor.author | Viswanathan, D | |
dc.contributor.author |
Hodge, C https://orcid.org/0000-0002-0516-6486 |
|
dc.contributor.author | Sutton, G | |
dc.contributor.author | Chan, C | |
dc.contributor.author | Males, JJ | |
dc.date.accessioned | 2022-09-09T05:26:59Z | |
dc.date.available | 2022-09-09T05:26:59Z | |
dc.date.issued | 2017-05 | |
dc.identifier.citation | Asia - Pacific Journal of Ophthalmology, 2017, 6, (3), pp. 228-232 | |
dc.identifier.issn | 0129-1653 | |
dc.identifier.issn | 2162-0989 | |
dc.identifier.uri | http://hdl.handle.net/10453/161583 | |
dc.description.abstract | PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia. METHODS: Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis. RESULTS: At last follow-up, BSCVA improved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed. CONCLUSIONS: In the Australian setting, CXL has proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | Asia Pacific Academy of Ophthalmology | |
dc.relation.ispartof | Asia - Pacific Journal of Ophthalmology | |
dc.relation.isbasedon | 10.22608/APO.2016197 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1113 Opthalmology and Optometry | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Collagen | |
dc.subject.mesh | Cornea | |
dc.subject.mesh | Corneal Diseases | |
dc.subject.mesh | Corneal Topography | |
dc.subject.mesh | Cross-Linking Reagents | |
dc.subject.mesh | Dilatation, Pathologic | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Keratomileusis, Laser In Situ | |
dc.subject.mesh | Male | |
dc.subject.mesh | Myopia | |
dc.subject.mesh | Postoperative Complications | |
dc.subject.mesh | Postoperative Period | |
dc.subject.mesh | Refraction, Ocular | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Collagen | |
dc.subject.mesh | Cornea | |
dc.subject.mesh | Corneal Diseases | |
dc.subject.mesh | Corneal Topography | |
dc.subject.mesh | Cross-Linking Reagents | |
dc.subject.mesh | Dilatation, Pathologic | |
dc.subject.mesh | Female | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Keratomileusis, Laser In Situ | |
dc.subject.mesh | Male | |
dc.subject.mesh | Myopia | |
dc.subject.mesh | Postoperative Complications | |
dc.subject.mesh | Postoperative Period | |
dc.subject.mesh | Refraction, Ocular | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Cornea | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Corneal Diseases | |
dc.subject.mesh | Myopia | |
dc.subject.mesh | Dilatation, Pathologic | |
dc.subject.mesh | Postoperative Complications | |
dc.subject.mesh | Collagen | |
dc.subject.mesh | Cross-Linking Reagents | |
dc.subject.mesh | Corneal Topography | |
dc.subject.mesh | Refraction, Ocular | |
dc.subject.mesh | Treatment Outcome | |
dc.subject.mesh | Keratomileusis, Laser In Situ | |
dc.subject.mesh | Postoperative Period | |
dc.subject.mesh | Retrospective Studies | |
dc.subject.mesh | Follow-Up Studies | |
dc.subject.mesh | Adult | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.title | Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study. | |
dc.type | Journal Article | |
utslib.citation.volume | 6 | |
utslib.location.activity | China | |
utslib.for | 1113 Opthalmology and Optometry | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Health | |
utslib.copyright.status | closed_access | * |
pubs.consider-herdc | false | |
dc.date.updated | 2022-09-09T05:26:58Z | |
pubs.issue | 3 | |
pubs.publication-status | Published | |
pubs.volume | 6 | |
utslib.citation.issue | 3 |
Abstract:
PURPOSE: Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting. DESIGN: Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia. METHODS: Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis. RESULTS: At last follow-up, BSCVA improved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed. CONCLUSIONS: In the Australian setting, CXL has proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity.
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