Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial.

Chambers, SK; Occhipinti, S; Foley, E; Clutton, S; Legg, M; Berry, M; Stockler, MR; Frydenberg, M; Gardiner, RA; Lepore, SJ; Davis, ID; Smith, DP

Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial.

Chambers, SK Occhipinti, S Foley, E Clutton, S Legg, M Berry, M Stockler, MR Frydenberg, M Gardiner, RA Lepore, SJ Davis, ID Smith, DP

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Publisher:: AMER SOC CLINICAL ONCOLOGY
Publication Type:: Journal Article
Citation:: J Clin Oncol, 2017, 35, (3), pp. 291-297
Issue Date:: 2017-01-20

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Field	Value	Language
dc.contributor.author	Chambers, SK
dc.contributor.author	Occhipinti, S
dc.contributor.author	Foley, E
dc.contributor.author	Clutton, S
dc.contributor.author	Legg, M
dc.contributor.author	Berry, M
dc.contributor.author	Stockler, MR
dc.contributor.author	Frydenberg, M
dc.contributor.author	Gardiner, RA
dc.contributor.author	Lepore, SJ
dc.contributor.author	Davis, ID
dc.contributor.author	Smith, DP
dc.date.accessioned	2022-10-02T22:27:33Z
dc.date.available	2022-10-02T22:27:33Z
dc.date.issued	2017-01-20
dc.identifier.citation	J Clin Oncol, 2017, 35, (3), pp. 291-297
dc.identifier.issn	0732-183X
dc.identifier.issn	1527-7755
dc.identifier.uri	http://hdl.handle.net/10453/162207
dc.description.abstract	Purpose Advanced prostate cancer (PC) is associated with substantial psychosocial morbidity. We sought to determine whether mindfulness-based cognitive therapy (MBCT) reduces distress in men with advanced PC. Methods Men with advanced PC (proven metastatic and/or castration-resistant biochemical progression) were randomly assigned to an 8-week, group-based MBCT intervention delivered by telephone (n = 94) or to minimally enhanced usual care (n = 95). Primary intervention outcomes were psychological distress, cancer-specific distress, and prostate-specific antigen anxiety. Mindfulness skills were assessed as potential mediators of effect. Participants were assessed at baseline and were followed up at 3, 6, and 9 months. Main statistical analyses were conducted on the basis of intention to treat. Results Fourteen MBCT groups were conducted in the intervention arm. Facilitator adherence ratings were high (> 93%). Using random-effects mixed-regression models, intention-to-treat analyses indicated no significant changes in intervention outcomes or in engagement with mindfulness for men in MBCT compared with those receiving minimally enhanced usual care. Per-protocol analyses also found no differences between arms in outcomes or engagement, with the exception of the mindfulness skill of observing, which increased over time for men in MBCT compared with usual care ( P = .032). Conclusion MBCT in this format was not more effective than minimally enhanced usual care in reducing distress in men with advanced PC. Future intervention research for these men should consider approaches that map more closely to masculinity.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	AMER SOC CLINICAL ONCOLOGY
dc.relation.ispartof	J Clin Oncol
dc.relation.isbasedon	10.1200/JCO.2016.68.8788
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1103 Clinical Sciences, 1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.subject.mesh	Adaptation, Psychological
dc.subject.mesh	Aged
dc.subject.mesh	Australia
dc.subject.mesh	Cognitive Behavioral Therapy
dc.subject.mesh	Cost of Illness
dc.subject.mesh	Health Knowledge, Attitudes, Practice
dc.subject.mesh	Humans
dc.subject.mesh	Intention to Treat Analysis
dc.subject.mesh	Male
dc.subject.mesh	Middle Aged
dc.subject.mesh	Mindfulness
dc.subject.mesh	Patient Education as Topic
dc.subject.mesh	Prostatic Neoplasms, Castration-Resistant
dc.subject.mesh	Psychotherapy, Group
dc.subject.mesh	Quality of Life
dc.subject.mesh	Remote Consultation
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Time Factors
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Humans
dc.subject.mesh	Treatment Outcome
dc.subject.mesh	Adaptation, Psychological
dc.subject.mesh	Health Knowledge, Attitudes, Practice
dc.subject.mesh	Stress, Psychological
dc.subject.mesh	Psychotherapy, Group
dc.subject.mesh	Remote Consultation
dc.subject.mesh	Time Factors
dc.subject.mesh	Cost of Illness
dc.subject.mesh	Quality of Life
dc.subject.mesh	Aged
dc.subject.mesh	Middle Aged
dc.subject.mesh	Australia
dc.subject.mesh	Male
dc.subject.mesh	Patient Education as Topic
dc.subject.mesh	Intention to Treat Analysis
dc.subject.mesh	Prostatic Neoplasms, Castration-Resistant
dc.subject.mesh	Mindfulness
dc.subject.mesh	Cognitive Behavioral Therapy
dc.title	Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial.
dc.type	Journal Article
utslib.citation.volume	35
utslib.location.activity	United States
utslib.for	1103 Clinical Sciences
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
dc.date.updated	2022-10-02T22:27:30Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	35
utslib.citation.issue	3

Abstract:

Purpose Advanced prostate cancer (PC) is associated with substantial psychosocial morbidity. We sought to determine whether mindfulness-based cognitive therapy (MBCT) reduces distress in men with advanced PC. Methods Men with advanced PC (proven metastatic and/or castration-resistant biochemical progression) were randomly assigned to an 8-week, group-based MBCT intervention delivered by telephone (n = 94) or to minimally enhanced usual care (n = 95). Primary intervention outcomes were psychological distress, cancer-specific distress, and prostate-specific antigen anxiety. Mindfulness skills were assessed as potential mediators of effect. Participants were assessed at baseline and were followed up at 3, 6, and 9 months. Main statistical analyses were conducted on the basis of intention to treat. Results Fourteen MBCT groups were conducted in the intervention arm. Facilitator adherence ratings were high (> 93%). Using random-effects mixed-regression models, intention-to-treat analyses indicated no significant changes in intervention outcomes or in engagement with mindfulness for men in MBCT compared with those receiving minimally enhanced usual care. Per-protocol analyses also found no differences between arms in outcomes or engagement, with the exception of the mindfulness skill of observing, which increased over time for men in MBCT compared with usual care ( P = .032). Conclusion MBCT in this format was not more effective than minimally enhanced usual care in reducing distress in men with advanced PC. Future intervention research for these men should consider approaches that map more closely to masculinity.

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http://hdl.handle.net/10453/162207