ACTN3 (R577X) Genotype Is Associated With Australian Football League Players.

Jacob, Y; Hart, NH; Cochrane, JL; Spiteri, T; Laws, SM; Jones, A; Rogalski, B; Kenna, J; Anderton, RS

ACTN3 (R577X) Genotype Is Associated With Australian Football League Players.

Jacob, Y Hart, NH Cochrane, JL Spiteri, T Laws, SM Jones, A Rogalski, B Kenna, J Anderton, RS

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Publisher:: Lippincott, Williams & Wilkins
Publication Type:: Journal Article
Citation:: Journal of Strength and Conditioning Research, 2022, 36, (2), pp. 573-576
Issue Date:: 2022-02-01

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Field	Value	Language
dc.contributor.author	Jacob, Y
dc.contributor.author	Hart, NH
dc.contributor.author	Cochrane, JL
dc.contributor.author	Spiteri, T
dc.contributor.author	Laws, SM
dc.contributor.author	Jones, A
dc.contributor.author	Rogalski, B
dc.contributor.author	Kenna, J
dc.contributor.author	Anderton, RS
dc.date.accessioned	2022-10-25T02:47:50Z
dc.date.available	2022-10-25T02:47:50Z
dc.date.issued	2022-02-01
dc.identifier.citation	Journal of Strength and Conditioning Research, 2022, 36, (2), pp. 573-576
dc.identifier.issn	1064-8011
dc.identifier.issn	1533-4287
dc.identifier.uri	http://hdl.handle.net/10453/162670
dc.description.abstract	ABSTRACT: Jacob, Y, Hart, NH, Cochrane, JL, Spiteri, T, Laws, SM, Jones, A, Rogalski, B, Kenna, J, and Anderton, RS. ACTN3 (R577X) genotype is associated with Australian Football League players. J Strength Cond Res 36(2): 573-576, 2022-Genetic variants in the angiotensin-converting enzyme (ACE) and alpha actinin-3 (ACTN3) genes have been associated with elite sport athletic performance. This study aimed to investigate the frequency of each polymorphism in a cohort of elite Australian football (AF) players. To achieve this, 47 players from an Australian Football League (AFL) club and 59 healthy age matched controls with no history of elite sporting competition were recruited for this study. Each subject provided saliva samples through buccal swab for DNA extraction and genotyping, with group comparisons made using χ2 and odds ratio analysis. There was no significant difference in ACE I/D genotype between healthy control and elite AF players. The ACTN3 XX genotype was significantly underrepresented in AFL players (4.3%) compared with healthy controls (28.8%, p = 0.003). In addition, there was a greater representation of the R allele in elite AF players (70.2%) when compared with healthy controls (50%; χ2 = 8.834, p = 0.002). This is the first study to investigate genetic variants in elite AF players, with results suggesting that the ACTN3 gene may play a significant role explaining aspects of athletic performance in AF.
dc.format	Print
dc.language	eng
dc.publisher	Lippincott, Williams & Wilkins
dc.relation.ispartof	Journal of Strength and Conditioning Research
dc.relation.isbasedon	10.1519/JSC.0000000000003458
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1106 Human Movement and Sports Sciences, 1116 Medical Physiology
dc.subject.classification	Sport Sciences
dc.subject.mesh	Actinin
dc.subject.mesh	Athletes
dc.subject.mesh	Athletic Performance
dc.subject.mesh	Australia
dc.subject.mesh	Football
dc.subject.mesh	Genotype
dc.subject.mesh	Humans
dc.subject.mesh	Actinin
dc.subject.mesh	Athletes
dc.subject.mesh	Athletic Performance
dc.subject.mesh	Australia
dc.subject.mesh	Football
dc.subject.mesh	Genotype
dc.subject.mesh	Humans
dc.subject.mesh	Humans
dc.subject.mesh	Actinin
dc.subject.mesh	Genotype
dc.subject.mesh	Football
dc.subject.mesh	Australia
dc.subject.mesh	Athletic Performance
dc.subject.mesh	Athletes
dc.title	ACTN3 (R577X) Genotype Is Associated With Australian Football League Players.
dc.type	Journal Article
utslib.citation.volume	36
utslib.location.activity	United States
utslib.for	1106 Human Movement and Sports Sciences
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-10-25T02:47:49Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	36
utslib.citation.issue	2

Abstract:

ABSTRACT: Jacob, Y, Hart, NH, Cochrane, JL, Spiteri, T, Laws, SM, Jones, A, Rogalski, B, Kenna, J, and Anderton, RS. ACTN3 (R577X) genotype is associated with Australian Football League players. J Strength Cond Res 36(2): 573-576, 2022-Genetic variants in the angiotensin-converting enzyme (ACE) and alpha actinin-3 (ACTN3) genes have been associated with elite sport athletic performance. This study aimed to investigate the frequency of each polymorphism in a cohort of elite Australian football (AF) players. To achieve this, 47 players from an Australian Football League (AFL) club and 59 healthy age matched controls with no history of elite sporting competition were recruited for this study. Each subject provided saliva samples through buccal swab for DNA extraction and genotyping, with group comparisons made using χ2 and odds ratio analysis. There was no significant difference in ACE I/D genotype between healthy control and elite AF players. The ACTN3 XX genotype was significantly underrepresented in AFL players (4.3%) compared with healthy controls (28.8%, p = 0.003). In addition, there was a greater representation of the R allele in elite AF players (70.2%) when compared with healthy controls (50%; χ2 = 8.834, p = 0.002). This is the first study to investigate genetic variants in elite AF players, with results suggesting that the ACTN3 gene may play a significant role explaining aspects of athletic performance in AF.

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http://hdl.handle.net/10453/162670