Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease.

Aggarwal, T; Wadhwa, R; Rohil, V; Maurya, PK

Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease.

Aggarwal, T Wadhwa, R Rohil, V Maurya, PK

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Publisher:: Informa UK Limited
Publication Type:: Journal Article
Citation:: Arch Physiol Biochem, 2018, 124, (3), pp. 226-231
Issue Date:: 2018-07

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Field	Value	Language
dc.contributor.author	Aggarwal, T
dc.contributor.author	Wadhwa, R
dc.contributor.author	Rohil, V
dc.contributor.author	Maurya, PK
dc.date.accessioned	2022-10-29T07:45:28Z
dc.date.available	2022-10-29T07:45:28Z
dc.date.issued	2018-07
dc.identifier.citation	Arch Physiol Biochem, 2018, 124, (3), pp. 226-231
dc.identifier.issn	1381-3455
dc.identifier.issn	1744-4160
dc.identifier.uri	http://hdl.handle.net/10453/162861
dc.description.abstract	CONTENT: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways. OBJECTIVE: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein-protein interaction (PPI) network. MATERIALS AND METHODS: The study was conducted on healthy subjects with normal lung function (NS, 14 subjects) and 28 patients (Global Initiative for Chronic Obstructive Lung Disease (Gold) 1 and Gold 2) with COPD. RESULTS: There was significant (p < .001) increase in MMP-12, MDA and uric acid levels as compared to healthy controls. A significant (p < .001) decline in ascorbic acid level was observed in COPD patients. The PPI was found to be 0.833 which indicated that proteins present in COPD are linked. DISCUSSION AND CONCLUSION: This study suggests oxidative stress plays an important role in COPD and the PPI provide indication that proteins present in COPD are linked.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Informa UK Limited
dc.relation.ispartof	Arch Physiol Biochem
dc.relation.isbasedon	10.1080/13813455.2017.1387796
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology, 0606 Physiology, 1116 Medical Physiology
dc.subject.classification	Endocrinology & Metabolism
dc.subject.mesh	Ascorbic Acid
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Female
dc.subject.mesh	Gene Expression Regulation, Enzymologic
dc.subject.mesh	Humans
dc.subject.mesh	Male
dc.subject.mesh	Malondialdehyde
dc.subject.mesh	Matrix Metalloproteinase 12
dc.subject.mesh	Middle Aged
dc.subject.mesh	Oxidative Stress
dc.subject.mesh	Protein Interaction Maps
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Uric Acid
dc.subject.mesh	Humans
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive
dc.subject.mesh	Malondialdehyde
dc.subject.mesh	Ascorbic Acid
dc.subject.mesh	Uric Acid
dc.subject.mesh	Case-Control Studies
dc.subject.mesh	Gene Expression Regulation, Enzymologic
dc.subject.mesh	Oxidative Stress
dc.subject.mesh	Middle Aged
dc.subject.mesh	Female
dc.subject.mesh	Male
dc.subject.mesh	Matrix Metalloproteinase 12
dc.subject.mesh	Protein Interaction Maps
dc.title	Biomarkers of oxidative stress and protein-protein interaction in chronic obstructive pulmonary disease.
dc.type	Journal Article
utslib.citation.volume	124
utslib.location.activity	England
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	0606 Physiology
utslib.for	1116 Medical Physiology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	closed_access	*
dc.date.updated	2022-10-29T07:45:27Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	124
utslib.citation.issue	3

Abstract:

CONTENT: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways. OBJECTIVE: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein-protein interaction (PPI) network. MATERIALS AND METHODS: The study was conducted on healthy subjects with normal lung function (NS, 14 subjects) and 28 patients (Global Initiative for Chronic Obstructive Lung Disease (Gold) 1 and Gold 2) with COPD. RESULTS: There was significant (p < .001) increase in MMP-12, MDA and uric acid levels as compared to healthy controls. A significant (p < .001) decline in ascorbic acid level was observed in COPD patients. The PPI was found to be 0.833 which indicated that proteins present in COPD are linked. DISCUSSION AND CONCLUSION: This study suggests oxidative stress plays an important role in COPD and the PPI provide indication that proteins present in COPD are linked.

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http://hdl.handle.net/10453/162861