Advanced Cancer Patient Knowledge of and Attitudes towards Tumor Molecular Profiling.

Davies, G; Butow, P; Napier, CE; Bartley, N; Juraskova, I; Meiser, B; Ballinger, ML; Thomas, DM; Schlub, TE; Best, MC; members of the PiGeOn Project,

Advanced Cancer Patient Knowledge of and Attitudes towards Tumor Molecular Profiling.

Davies, G Butow, P Napier, CE Bartley, N

Juraskova, I Meiser, B Ballinger, ML Thomas, DM Schlub, TE Best, MC members of the PiGeOn Project,

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Publisher:: ELSEVIER SCIENCE INC
Publication Type:: Journal Article
Citation:: Transl Oncol, 2020, 13, (9), pp. 100799
Issue Date:: 2020-09

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Field	Value	Language
dc.contributor.author	Davies, G
dc.contributor.author	Butow, P
dc.contributor.author	Napier, CE
dc.contributor.author	Bartley, N https://orcid.org/0000-0001-9052-1616
dc.contributor.author	Juraskova, I
dc.contributor.author	Meiser, B
dc.contributor.author	Ballinger, ML
dc.contributor.author	Thomas, DM
dc.contributor.author	Schlub, TE
dc.contributor.author	Best, MC
dc.contributor.author	members of the PiGeOn Project,
dc.date.accessioned	2022-10-30T21:08:37Z
dc.date.available	2020-05-04
dc.date.available	2022-10-30T21:08:37Z
dc.date.issued	2020-09
dc.identifier.citation	Transl Oncol, 2020, 13, (9), pp. 100799
dc.identifier.issn	1936-5233
dc.identifier.issn	1936-5233
dc.identifier.uri	http://hdl.handle.net/10453/162975
dc.description.abstract	Limited research has indicated that despite their overwhelming interest in tumor molecular profiling (MP),1 cancer patients have poor knowledge about MP. The current study aimed to investigate demographic and psychological predictors of knowledge and perceived importance of MP in an advanced cancer patient cohort. Eligible participants had advanced solid cancers of any histological type with sufficient accessible tissue for MP and were enrolled in the Molecular Screening and Therapeutics (MoST) Program. A questionnaire was completed by 1074 participants (91% response rate) after consent, prior to undergoing MP. Overall, participants had poor to moderate knowledge of MP, yet perceived MP to have high importance. Higher education, speaking English at home, and greater satisfaction with the decision to undergo MP were associated with higher knowledge scores. More negative attitudes towards uncertainty, greater self-efficacy to cope with results, and lower perceived likelihood of cancer progression were associated with greater perceived importance of MP. Less educated participants and those who do not speak English at home will need clear explanations, visual aids and ample opportunity to ask questions about MP at the time of their decision-making. Clinicians also need to consider psychological factors relevant to patients' decision to pursue MP. Given the increased awareness of and demand for cancer genomic information and the rapidly changing nature of the actionability of MP, these findings will help inform an important ongoing debate on how to facilitate ethical and informed consent and manage patient expectations about personalized treatments.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ELSEVIER SCIENCE INC
dc.relation.ispartof	Transl Oncol
dc.relation.isbasedon	10.1016/j.tranon.2020.100799
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0601 Biochemistry and Cell Biology, 1103 Clinical Sciences, 1112 Oncology and Carcinogenesis
dc.subject.classification	Oncology & Carcinogenesis
dc.title	Advanced Cancer Patient Knowledge of and Attitudes towards Tumor Molecular Profiling.
dc.type	Journal Article
utslib.citation.volume	13
utslib.location.activity	United States
utslib.for	0601 Biochemistry and Cell Biology
utslib.for	1103 Clinical Sciences
utslib.for	1112 Oncology and Carcinogenesis
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
dc.date.updated	2022-10-30T21:08:31Z
pubs.issue	9
pubs.publication-status	Published
pubs.volume	13
utslib.citation.issue	9

Abstract:

Limited research has indicated that despite their overwhelming interest in tumor molecular profiling (MP),1 cancer patients have poor knowledge about MP. The current study aimed to investigate demographic and psychological predictors of knowledge and perceived importance of MP in an advanced cancer patient cohort. Eligible participants had advanced solid cancers of any histological type with sufficient accessible tissue for MP and were enrolled in the Molecular Screening and Therapeutics (MoST) Program. A questionnaire was completed by 1074 participants (91% response rate) after consent, prior to undergoing MP. Overall, participants had poor to moderate knowledge of MP, yet perceived MP to have high importance. Higher education, speaking English at home, and greater satisfaction with the decision to undergo MP were associated with higher knowledge scores. More negative attitudes towards uncertainty, greater self-efficacy to cope with results, and lower perceived likelihood of cancer progression were associated with greater perceived importance of MP. Less educated participants and those who do not speak English at home will need clear explanations, visual aids and ample opportunity to ask questions about MP at the time of their decision-making. Clinicians also need to consider psychological factors relevant to patients' decision to pursue MP. Given the increased awareness of and demand for cancer genomic information and the rapidly changing nature of the actionability of MP, these findings will help inform an important ongoing debate on how to facilitate ethical and informed consent and manage patient expectations about personalized treatments.

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http://hdl.handle.net/10453/162975