Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer.

Islam, MZ; Krajewska, M; Hossain, SI; Prochaska, K; Anwar, A; Deplazes, E; Saha, SC

Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer.

Islam, MZ Krajewska, M Hossain, SI Prochaska, K Anwar, A Deplazes, E

Saha, SC

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Publisher:: American Chemical Society
Publication Type:: Journal Article
Citation:: Langmuir: the ACS journal of surfaces and colloids, 2022, 38, (14), pp. 4188-4199
Issue Date:: 2022-04-12

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Field	Value	Language
dc.contributor.author	Islam, MZ
dc.contributor.author	Krajewska, M
dc.contributor.author	Hossain, SI
dc.contributor.author	Prochaska, K
dc.contributor.author	Anwar, A
dc.contributor.author	Deplazes, E https://orcid.org/0000-0003-2052-5536
dc.contributor.author	Saha, SC
dc.date.accessioned	2022-11-09T04:35:42Z
dc.date.available	2022-11-09T04:35:42Z
dc.date.issued	2022-04-12
dc.identifier.citation	Langmuir: the ACS journal of surfaces and colloids, 2022, 38, (14), pp. 4188-4199
dc.identifier.issn	0743-7463
dc.identifier.issn	1520-5827
dc.identifier.uri	http://hdl.handle.net/10453/163371
dc.description.abstract	The lung surfactant monolayer (LSM) is the main barrier for particles entering the lung, including steroid drugs used to treat lung diseases. The present study combines Langmuir experiments and coarse-grained (CG) molecular dynamics simulations to investigate the concentration-dependent effect of steroid drug prednisolone on the structure and morphology of a model LSM. The surface pressure-area isotherms for the Langmuir monolayers reveal a concentration-dependent decrease in area per lipid (APL). Results from simulations at a fixed surface tension, representing inhalation and exhalation conditions, suggest that at high drug concentrations, prednisolone induces a collapse of the LSM, which is likely caused by the inability of the drug to diffuse into the bilayer. Overall, the monolayer is most susceptible to drug-induced collapse at surface tensions representing exhalation conditions. The presence of cholesterol also exacerbates the instability. The findings of this investigation might be helpful for better understanding the interaction between steroid drug prednisolone and lung surfactants in relation to off-target effects.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American Chemical Society
dc.relation.ispartof	Langmuir: the ACS journal of surfaces and colloids
dc.relation.isbasedon	10.1021/acs.langmuir.1c02817
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject.classification	Chemical Physics
dc.subject.mesh	Lung
dc.subject.mesh	Prednisolone
dc.subject.mesh	Pulmonary Surfactants
dc.subject.mesh	Surface Tension
dc.subject.mesh	Surface-Active Agents
dc.subject.mesh	Lung
dc.subject.mesh	Prednisolone
dc.subject.mesh	Pulmonary Surfactants
dc.subject.mesh	Surface Tension
dc.subject.mesh	Surface-Active Agents
dc.subject.mesh	Lung
dc.subject.mesh	Prednisolone
dc.subject.mesh	Pulmonary Surfactants
dc.subject.mesh	Surface-Active Agents
dc.subject.mesh	Surface Tension
dc.title	Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer.
dc.type	Journal Article
utslib.citation.volume	38
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Mechanical and Mechatronic Engineering
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-09T04:35:33Z
pubs.issue	14
pubs.publication-status	Published
pubs.volume	38
utslib.citation.issue	14

Abstract:

The lung surfactant monolayer (LSM) is the main barrier for particles entering the lung, including steroid drugs used to treat lung diseases. The present study combines Langmuir experiments and coarse-grained (CG) molecular dynamics simulations to investigate the concentration-dependent effect of steroid drug prednisolone on the structure and morphology of a model LSM. The surface pressure-area isotherms for the Langmuir monolayers reveal a concentration-dependent decrease in area per lipid (APL). Results from simulations at a fixed surface tension, representing inhalation and exhalation conditions, suggest that at high drug concentrations, prednisolone induces a collapse of the LSM, which is likely caused by the inability of the drug to diffuse into the bilayer. Overall, the monolayer is most susceptible to drug-induced collapse at surface tensions representing exhalation conditions. The presence of cholesterol also exacerbates the instability. The findings of this investigation might be helpful for better understanding the interaction between steroid drug prednisolone and lung surfactants in relation to off-target effects.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/163371