Preferences for a polygenic test to estimate cancer risk in a general Australian population.

Venning, B; Saya, S; De Abreu Lourenco, R; Street, DJ; Emery, JD

Preferences for a polygenic test to estimate cancer risk in a general Australian population.

Venning, B Saya, S De Abreu Lourenco, R

Street, DJ Emery, JD

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Publisher:: American College of Medical Genetics and Genomics
Publication Type:: Journal Article
Citation:: Genetics in Medicine, 2022, 24, (10), pp. 2144-2154
Issue Date:: 2022-10

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Field	Value	Language
dc.contributor.author	Venning, B
dc.contributor.author	Saya, S
dc.contributor.author	De Abreu Lourenco, R https://orcid.org/0000-0002-5978-8774
dc.contributor.author	Street, DJ
dc.contributor.author	Emery, JD
dc.date.accessioned	2022-11-23T03:20:42Z
dc.date.available	2022-07-05
dc.date.available	2022-11-23T03:20:42Z
dc.date.issued	2022-10
dc.identifier.citation	Genetics in Medicine, 2022, 24, (10), pp. 2144-2154
dc.identifier.issn	1098-3600
dc.identifier.issn	1530-0366
dc.identifier.uri	http://hdl.handle.net/10453/163676
dc.description.abstract	PURPOSE: There is significant interest in the use of polygenic risk score (PRS) tests to improve cancer risk assessment and stratified prevention. Our current understanding of preferences regarding different aspects of this novel testing approach is limited. This study examined which attributes of a PRS test most influence the likelihood of testing. METHODS: A discrete choice experiment was developed to elicit preferences for different aspects of a PRS test by surveying an online sample of the Australian population. Preferences were assessed using mixed logistic regression, latent class analysis, and marginal willingness to pay. RESULTS: The 1002 surveyed respondents were more likely to choose a PRS test that was more accurate, tested for multiple cancer types, and enabled cancer risk reduction through lifestyle modification, screening, or medication. There was also a preference for testing through a primary care physician rather than online or through a genetic specialist. A test that did not impact life insurance eligibility or premiums was preferred over the one that did. CONCLUSION: This study found that the Australian population prefer a PRS test that is highly accurate, tests for multiple cancers, has noninvasive risk reduction measures, and is performed through primary care.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	American College of Medical Genetics and Genomics
dc.relation.ispartof	Genetics in Medicine
dc.relation.isbasedon	10.1016/j.gim.2022.07.011
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	0604 Genetics, 1103 Clinical Sciences
dc.subject.classification	Genetics & Heredity
dc.subject.mesh	Australia
dc.subject.mesh	Choice Behavior
dc.subject.mesh	Humans
dc.subject.mesh	Logistic Models
dc.subject.mesh	Mass Screening
dc.subject.mesh	Neoplasms
dc.subject.mesh	Patient Preference
dc.subject.mesh	Australia
dc.subject.mesh	Choice Behavior
dc.subject.mesh	Humans
dc.subject.mesh	Logistic Models
dc.subject.mesh	Mass Screening
dc.subject.mesh	Neoplasms
dc.subject.mesh	Patient Preference
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Mass Screening
dc.subject.mesh	Logistic Models
dc.subject.mesh	Choice Behavior
dc.subject.mesh	Australia
dc.subject.mesh	Patient Preference
dc.title	Preferences for a polygenic test to estimate cancer risk in a general Australian population.
dc.type	Journal Article
utslib.citation.volume	24
utslib.location.activity	United States
utslib.for	0604 Genetics
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - CHERE - Centre for Health Economics Research and Evaluation
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
pubs.organisational-group	/University of Technology Sydney/Centre for Health Technologies (CHT)
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Centre for Health Economics Research and Evaluation
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-23T03:20:41Z
pubs.issue	10
pubs.publication-status	Published
pubs.volume	24
utslib.citation.issue	10

Abstract:

PURPOSE: There is significant interest in the use of polygenic risk score (PRS) tests to improve cancer risk assessment and stratified prevention. Our current understanding of preferences regarding different aspects of this novel testing approach is limited. This study examined which attributes of a PRS test most influence the likelihood of testing. METHODS: A discrete choice experiment was developed to elicit preferences for different aspects of a PRS test by surveying an online sample of the Australian population. Preferences were assessed using mixed logistic regression, latent class analysis, and marginal willingness to pay. RESULTS: The 1002 surveyed respondents were more likely to choose a PRS test that was more accurate, tested for multiple cancer types, and enabled cancer risk reduction through lifestyle modification, screening, or medication. There was also a preference for testing through a primary care physician rather than online or through a genetic specialist. A test that did not impact life insurance eligibility or premiums was preferred over the one that did. CONCLUSION: This study found that the Australian population prefer a PRS test that is highly accurate, tests for multiple cancers, has noninvasive risk reduction measures, and is performed through primary care.

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http://hdl.handle.net/10453/163676