Psychological predictors of cancer patients' and their relatives' attitudes towards the return of genomic sequencing results.

Meiser, B; Butow, P; Davies, G; Napier, CE; Schlub, TE; Bartley, N; Juraskova, I; Ballinger, ML; Thomas, DM; Best, MC; members of the Psychosocial Issues in Genomics in Oncology (PiGeOn) Project,; Jacobs, C

Psychological predictors of cancer patients' and their relatives' attitudes towards the return of genomic sequencing results.

Meiser, B Butow, P Davies, G Napier, CE Schlub, TE Bartley, N

Juraskova, I Ballinger, ML Thomas, DM Best, MC members of the Psychosocial Issues in Genomics in Oncology (PiGeOn) Project, Jacobs, C

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Publisher:: Elsevier
Publication Type:: Journal Article
Citation:: European Journal of Medical Genetics, 2022, 65, (6), pp. 1-7
Issue Date:: 2022-06

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Field	Value	Language
dc.contributor.author	Meiser, B
dc.contributor.author	Butow, P
dc.contributor.author	Davies, G
dc.contributor.author	Napier, CE
dc.contributor.author	Schlub, TE
dc.contributor.author	Bartley, N https://orcid.org/0000-0001-9052-1616
dc.contributor.author	Juraskova, I
dc.contributor.author	Ballinger, ML
dc.contributor.author	Thomas, DM
dc.contributor.author	Best, MC
dc.contributor.author	members of the Psychosocial Issues in Genomics in Oncology (PiGeOn) Project,
dc.contributor.author	Jacobs, C
dc.date.accessioned	2022-11-24T04:44:07Z
dc.date.available	2022-04-23
dc.date.available	2022-11-24T04:44:07Z
dc.date.issued	2022-06
dc.identifier.citation	European Journal of Medical Genetics, 2022, 65, (6), pp. 1-7
dc.identifier.issn	1769-7212
dc.identifier.issn	1878-0849
dc.identifier.uri	http://hdl.handle.net/10453/163723
dc.description.abstract	This study assessed the psychological predictors of attitudes toward the return of germline genomic sequencing results in cancer patients and their biological relatives with a likely genetic basis for their cancer diagnosis, who completed a questionnaire prior to undergoing genomic sequencing. Of 602 probands and relatives, 94% of probands and 89% of relatives thought people would like to be informed about single-gene conditions for which there is prevention or treatment. Amongst relatives, this view was associated with higher perceived susceptibility and self-efficacy. Probands (66%) and relatives (59%) thought people would be interested in learning about single-gene conditions for which there is no prevention or treatment. Amongst probands, this view was associated with lower tolerance of uncertainty and amongst relatives with higher self-efficacy. Probands (92%) and relatives (90%) thought people would like to be informed about polygenic conditions that can have a major impact on health. Amongst probands this view was associated with lower perceived susceptibility of cancer recurrence, and amongst relatives, with higher perceived susceptibility and self-efficacy. Probands (86%) and relatives (86%) thought that people would like to be informed about polygenic conditions that can have a lower impact on health, and this view was associated with a lower perceived susceptibility of recurrence amongst probands. In conclusion, these findings show that individuals' attitudes about the return of results depend on the perceived utility of different types of tests. Therefore, individuals need to gain a clear understanding of test utility, and appropriate consent processes are required to achieve informed choices.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Elsevier
dc.relation.ispartof	European Journal of Medical Genetics
dc.relation.isbasedon	10.1016/j.ejmg.2022.104516
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0604 Genetics, 1103 Clinical Sciences
dc.subject.classification	Genetics & Heredity
dc.subject.mesh	Attitude
dc.subject.mesh	Family
dc.subject.mesh	Genomics
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Surveys and Questionnaires
dc.subject.mesh	Attitude
dc.subject.mesh	Family
dc.subject.mesh	Genomics
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Surveys and Questionnaires
dc.subject.mesh	Humans
dc.subject.mesh	Neoplasms
dc.subject.mesh	Attitude
dc.subject.mesh	Family
dc.subject.mesh	Genomics
dc.subject.mesh	Surveys and Questionnaires
dc.title	Psychological predictors of cancer patients' and their relatives' attitudes towards the return of genomic sequencing results.
dc.type	Journal Article
utslib.citation.volume	65
utslib.location.activity	Netherlands
utslib.for	0604 Genetics
utslib.for	1103 Clinical Sciences
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	closed_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-24T04:44:06Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	65
utslib.citation.issue	6

Abstract:

This study assessed the psychological predictors of attitudes toward the return of germline genomic sequencing results in cancer patients and their biological relatives with a likely genetic basis for their cancer diagnosis, who completed a questionnaire prior to undergoing genomic sequencing. Of 602 probands and relatives, 94% of probands and 89% of relatives thought people would like to be informed about single-gene conditions for which there is prevention or treatment. Amongst relatives, this view was associated with higher perceived susceptibility and self-efficacy. Probands (66%) and relatives (59%) thought people would be interested in learning about single-gene conditions for which there is no prevention or treatment. Amongst probands, this view was associated with lower tolerance of uncertainty and amongst relatives with higher self-efficacy. Probands (92%) and relatives (90%) thought people would like to be informed about polygenic conditions that can have a major impact on health. Amongst probands this view was associated with lower perceived susceptibility of cancer recurrence, and amongst relatives, with higher perceived susceptibility and self-efficacy. Probands (86%) and relatives (86%) thought that people would like to be informed about polygenic conditions that can have a lower impact on health, and this view was associated with a lower perceived susceptibility of recurrence amongst probands. In conclusion, these findings show that individuals' attitudes about the return of results depend on the perceived utility of different types of tests. Therefore, individuals need to gain a clear understanding of test utility, and appropriate consent processes are required to achieve informed choices.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/163723