Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study.

Viljoen, B; Hofman, MS; Chambers, SK; Dunn, J; Dhillon, HM; Davis, ID; Ralph, N

Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study.

Viljoen, B Hofman, MS Chambers, SK Dunn, J Dhillon, HM Davis, ID Ralph, N

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Publisher:: Public Library of Science (PLoS)
Publication Type:: Journal Article
Citation:: PLoS One, 2022, 17, (11), pp. 1-15
Issue Date:: 2022

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Field	Value	Language
dc.contributor.author	Viljoen, B
dc.contributor.author	Hofman, MS
dc.contributor.author	Chambers, SK
dc.contributor.author	Dunn, J
dc.contributor.author	Dhillon, HM
dc.contributor.author	Davis, ID
dc.contributor.author	Ralph, N
dc.date.accessioned	2022-11-29T02:46:14Z
dc.date.available	2022-09-27
dc.date.available	2022-11-29T02:46:14Z
dc.date.issued	2022
dc.identifier.citation	PLoS One, 2022, 17, (11), pp. 1-15
dc.identifier.issn	1932-6203
dc.identifier.issn	1932-6203
dc.identifier.uri	http://hdl.handle.net/10453/163807
dc.description.abstract	OBJECTIVES: Qualitative studies nested within clinical trials can provide insight into the treatment experience, how this evolves over time and where improved supportive care is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of 177Lu-PSMA-617 compared with cabazitaxel chemotherapy. METHODS: Fifteen men with advanced prostate cancer were recruited from the TheraP clinical trial with interviews conducted at three timepoints during the trial. An interpretative phenomenological approach was used, and interviews analysed using thematic analysis. This research paper reports the results from the mid-point, conclusion and follow up interviews, focusing specifically on participants' experiences of trial participation. RESULTS: Three themes were identified representing the lived experiences of men with advanced prostate cancer participating in the TheraP trial: (1) facing limited options; (2) anticipating outcomes and (3) coping with health changes. CONCLUSIONS: Men who enrol in clinical trial of anti-neoplastic treatments for prostate cancer need targeted psychological and supportive care that includes attention to unique aspects of the experience of having prostate cancer and being in a clinical trial. As part of their trial experience, men with advanced prostate cancer need to be regularly assessed for survivorship needs, fully informed, supported and referred to services for regular care and support across the trajectory of their disease. TRIAL REGISTRATION: NCT03392428. Registered on 8 January 2018 (ANZUP1603).
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	Public Library of Science (PLoS)
dc.relation.ispartof	PLoS One
dc.relation.isbasedon	10.1371/journal.pone.0276063
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	General Science & Technology
dc.subject.mesh	Adaptation, Psychological
dc.subject.mesh	Humans
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Male
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Qualitative Research
dc.subject.mesh	Survivorship
dc.subject.mesh	Male
dc.subject.mesh	Humans
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Qualitative Research
dc.subject.mesh	Adaptation, Psychological
dc.subject.mesh	Survivorship
dc.subject.mesh	Humans
dc.subject.mesh	Prostatic Neoplasms
dc.subject.mesh	Longitudinal Studies
dc.subject.mesh	Adaptation, Psychological
dc.subject.mesh	Qualitative Research
dc.subject.mesh	Male
dc.subject.mesh	Survivorship
dc.title	Experiences of participants in a clinical trial of a novel radioactive treatment for advanced prostate cancer: A nested, qualitative longitudinal study.
dc.type	Journal Article
utslib.citation.volume	17
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-11-29T02:46:13Z
pubs.issue	11
pubs.publication-status	Published
pubs.volume	17
utslib.citation.issue	11

Abstract:

OBJECTIVES: Qualitative studies nested within clinical trials can provide insight into the treatment experience, how this evolves over time and where improved supportive care is required. The purpose of this qualitative study is to describe the lived experiences of men with advanced prostate cancer participating in the TheraP trial; a randomised trial of 177Lu-PSMA-617 compared with cabazitaxel chemotherapy. METHODS: Fifteen men with advanced prostate cancer were recruited from the TheraP clinical trial with interviews conducted at three timepoints during the trial. An interpretative phenomenological approach was used, and interviews analysed using thematic analysis. This research paper reports the results from the mid-point, conclusion and follow up interviews, focusing specifically on participants' experiences of trial participation. RESULTS: Three themes were identified representing the lived experiences of men with advanced prostate cancer participating in the TheraP trial: (1) facing limited options; (2) anticipating outcomes and (3) coping with health changes. CONCLUSIONS: Men who enrol in clinical trial of anti-neoplastic treatments for prostate cancer need targeted psychological and supportive care that includes attention to unique aspects of the experience of having prostate cancer and being in a clinical trial. As part of their trial experience, men with advanced prostate cancer need to be regularly assessed for survivorship needs, fully informed, supported and referred to services for regular care and support across the trajectory of their disease. TRIAL REGISTRATION: NCT03392428. Registered on 8 January 2018 (ANZUP1603).

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http://hdl.handle.net/10453/163807