Hormonal contraceptive use and the risk of sexually transmitted infections: a systematic review and meta-analysis.

Akter, T; Festin, M; Dawson, A

Hormonal contraceptive use and the risk of sexually transmitted infections: a systematic review and meta-analysis.

Akter, T Festin, M Dawson, A

Permalink

Publisher:: Nature Publishing Group
Publication Type:: Journal Article
Citation:: Scientific Reports, 2022, 12, (1), pp. 1-17
Issue Date:: 2022-11-25

Open Access

Copyright Clearance Process

Recently Added
In Progress
Open Access

This item is open access.

Adobe PDF

Download full textAdobe PDF (1.32 MB)

View on publisher's site

View statistics

Full metadata record

Field	Value	Language
dc.contributor.author	Akter, T
dc.contributor.author	Festin, M
dc.contributor.author	Dawson, A https://orcid.org/0000-0003-0926-2202
dc.date.accessioned	2022-12-04T23:48:29Z
dc.date.available	2022-11-17
dc.date.available	2022-12-04T23:48:29Z
dc.date.issued	2022-11-25
dc.identifier.citation	Scientific Reports, 2022, 12, (1), pp. 1-17
dc.identifier.issn	2045-2322
dc.identifier.issn	2045-2322
dc.identifier.uri	http://hdl.handle.net/10453/164085
dc.description.abstract	There are 150 million women worldwide using combined or progestogen-only hormonal contraceptive methods who may be at risk of sexually transmitted infections (STIs). Previous systematic reviews that have sought to establish whether there is an aetiological association between hormonal contraceptive methods/use and STIs have been limited in their methods and have mixed findings. We sought to update these reviews using appropriate control groups. We undertook a systematic review following the PRISMA guidelines and meta-analysis to examine the association between the use of all hormonal contraceptive methods and the acquisition of STIs (Neisseria gonorrhoeae, syphilis/Treponema pallidum, Chlamydia trachomatis, herpes simplex virus, and Trichomonas vaginalis) and/or bacterial vaginosis in literature published between 2005 and 2020. We analysed the effect of hormonal contraceptive methods/use separately on the prevalence, incidence and recurrence of STIs. A total of 37 studies were included in this review that reported 61 associations, in which 27 prevalence, eight incidence and two recurrence studies provided 43, 16, and two associations, respectively. We observed a positive association between hormonal contraceptive methods/use and the risk of chlamydia and herpes but a negative association for trichomoniasis and vaginosis. A negative but statistically insignificant association was observed between hormonal contraceptive methods/use and gonorrhoea. Hormonal contraceptive methods/use influences a woman's risk of STIs/ bacterial vaginosis, but the risk may differ depending on the type of STI. These findings should be contextualized carefully, particularly when formulating practice guidelines and policy, as the effects of hormonal contraceptive methods/use on the risk of STIs varied in direction when analysed separately by STI.
dc.format	Electronic
dc.language	eng
dc.publisher	Nature Publishing Group
dc.relation.ispartof	Scientific Reports
dc.relation.isbasedon	10.1038/s41598-022-24601-y
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Female
dc.subject.mesh	Gonorrhea
dc.subject.mesh	Herpes Simplex
dc.subject.mesh	Humans
dc.subject.mesh	Sexually Transmitted Diseases
dc.subject.mesh	Trichomonas Infections
dc.subject.mesh	Vaginosis, Bacterial
dc.subject.mesh	Humans
dc.subject.mesh	Female
dc.subject.mesh	Vaginosis, Bacterial
dc.subject.mesh	Sexually Transmitted Diseases
dc.subject.mesh	Trichomonas Infections
dc.subject.mesh	Gonorrhea
dc.subject.mesh	Herpes Simplex
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Humans
dc.subject.mesh	Gonorrhea
dc.subject.mesh	Vaginosis, Bacterial
dc.subject.mesh	Sexually Transmitted Diseases
dc.subject.mesh	Herpes Simplex
dc.subject.mesh	Trichomonas Infections
dc.subject.mesh	Contraceptive Agents
dc.subject.mesh	Female
dc.title	Hormonal contraceptive use and the risk of sexually transmitted infections: a systematic review and meta-analysis.
dc.type	Journal Article
utslib.citation.volume	12
utslib.location.activity	England
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Strength - WHO CC
utslib.copyright.status	open_access	*
pubs.consider-herdc	false
dc.date.updated	2022-12-04T23:48:27Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	12
utslib.citation.issue	1

Abstract:

There are 150 million women worldwide using combined or progestogen-only hormonal contraceptive methods who may be at risk of sexually transmitted infections (STIs). Previous systematic reviews that have sought to establish whether there is an aetiological association between hormonal contraceptive methods/use and STIs have been limited in their methods and have mixed findings. We sought to update these reviews using appropriate control groups. We undertook a systematic review following the PRISMA guidelines and meta-analysis to examine the association between the use of all hormonal contraceptive methods and the acquisition of STIs (Neisseria gonorrhoeae, syphilis/Treponema pallidum, Chlamydia trachomatis, herpes simplex virus, and Trichomonas vaginalis) and/or bacterial vaginosis in literature published between 2005 and 2020. We analysed the effect of hormonal contraceptive methods/use separately on the prevalence, incidence and recurrence of STIs. A total of 37 studies were included in this review that reported 61 associations, in which 27 prevalence, eight incidence and two recurrence studies provided 43, 16, and two associations, respectively. We observed a positive association between hormonal contraceptive methods/use and the risk of chlamydia and herpes but a negative association for trichomoniasis and vaginosis. A negative but statistically insignificant association was observed between hormonal contraceptive methods/use and gonorrhoea. Hormonal contraceptive methods/use influences a woman's risk of STIs/ bacterial vaginosis, but the risk may differ depending on the type of STI. These findings should be contextualized carefully, particularly when formulating practice guidelines and policy, as the effects of hormonal contraceptive methods/use on the risk of STIs varied in direction when analysed separately by STI.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/164085