High selective property of gelatin/MWCNTs functionalized carbon fiber microelectrode: Toward real-time monitoring of ascorbate

Deng, Z; Zhao, L; Mu, H; Jiang, L; Xi, W; Xu, X; Zheng, W

High selective property of gelatin/MWCNTs functionalized carbon fiber microelectrode: Toward real-time monitoring of ascorbate

Deng, Z Zhao, L Mu, H Jiang, L Xi, W Xu, X

Zheng, W

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Publisher:: ELSEVIER SCIENCE SA
Publication Type:: Journal Article
Citation:: Journal of Electroanalytical Chemistry, 2022, 914
Issue Date:: 2022-06-01

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Field	Value	Language
dc.contributor.author	Deng, Z
dc.contributor.author	Zhao, L
dc.contributor.author	Mu, H
dc.contributor.author	Jiang, L
dc.contributor.author	Xi, W
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Zheng, W
dc.date.accessioned	2023-01-18T04:17:56Z
dc.date.available	2023-01-18T04:17:56Z
dc.date.issued	2022-06-01
dc.identifier.citation	Journal of Electroanalytical Chemistry, 2022, 914
dc.identifier.issn	1572-6657
dc.identifier.issn	1873-2569
dc.identifier.uri	http://hdl.handle.net/10453/165108
dc.description.abstract	Carbon nanotubes (CNTs) as one of powerful materials for in vivo electrochemistry sensing. However, the construction of CNTs as the bio-interface on the electrode surface is still limited because of the toxicity. On the other hand, the adsorption of proteins also renders a great challenge against the stability and sensitivity of implanted electrode. In this work, we validated the protein pre-treated strategy as an effective pre-correction way for the in vivo monitoring of neurochemical small molecule using the gelatin-MWCNTs functionalized carbon fiber microelectrodes (gelatin-MWCNTs/CFME). The gelatin-MWCNTs/CFME presented excellent stability and selectivity with well-maintained sensitivity, which was almost the same as that of the pre-correction. In addition, the well-maintained sensitivity enabled the gelatin-MWCNTs/CFME to detect the ascorbate in human blood sample and be interference-free from proteins. More remarkable, the gelatin-MWCNTs presented excellent biocompatibility. The superior properties along with an improvement in the biocompatibility of CNTs has made the gelatin-MWCNTs a promising candidate to be used as in in vivo electrochemical sensing.
dc.language	English
dc.publisher	ELSEVIER SCIENCE SA
dc.relation.ispartof	Journal of Electroanalytical Chemistry
dc.relation.isbasedon	10.1016/j.jelechem.2022.116315
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0301 Analytical Chemistry, 0303 Macromolecular and Materials Chemistry, 0307 Theoretical and Computational Chemistry
dc.title	High selective property of gelatin/MWCNTs functionalized carbon fiber microelectrode: Toward real-time monitoring of ascorbate
dc.type	Journal Article
utslib.citation.volume	914
utslib.for	0301 Analytical Chemistry
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0307 Theoretical and Computational Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-01-18T04:17:53Z
pubs.publication-status	Published
pubs.volume	914

Abstract:

Carbon nanotubes (CNTs) as one of powerful materials for in vivo electrochemistry sensing. However, the construction of CNTs as the bio-interface on the electrode surface is still limited because of the toxicity. On the other hand, the adsorption of proteins also renders a great challenge against the stability and sensitivity of implanted electrode. In this work, we validated the protein pre-treated strategy as an effective pre-correction way for the in vivo monitoring of neurochemical small molecule using the gelatin-MWCNTs functionalized carbon fiber microelectrodes (gelatin-MWCNTs/CFME). The gelatin-MWCNTs/CFME presented excellent stability and selectivity with well-maintained sensitivity, which was almost the same as that of the pre-correction. In addition, the well-maintained sensitivity enabled the gelatin-MWCNTs/CFME to detect the ascorbate in human blood sample and be interference-free from proteins. More remarkable, the gelatin-MWCNTs presented excellent biocompatibility. The superior properties along with an improvement in the biocompatibility of CNTs has made the gelatin-MWCNTs a promising candidate to be used as in in vivo electrochemical sensing.

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http://hdl.handle.net/10453/165108