Recent advances in electrochemical analysis of hydrogen peroxide towards in vivo detection

Deng, Z; Zhao, L; Zhou, H; Xu, X; Zheng, W

Recent advances in electrochemical analysis of hydrogen peroxide towards in vivo detection

Deng, Z Zhao, L Zhou, H Xu, X

Zheng, W

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Publisher:: ELSEVIER SCI LTD
Publication Type:: Journal Article
Citation:: Process Biochemistry, 2022, 115, pp. 57-69
Issue Date:: 2022-04-01

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Field	Value	Language
dc.contributor.author	Deng, Z
dc.contributor.author	Zhao, L
dc.contributor.author	Zhou, H
dc.contributor.author	Xu, X https://orcid.org/0000-0002-2598-3766
dc.contributor.author	Zheng, W
dc.date.accessioned	2023-01-18T04:18:57Z
dc.date.available	2023-01-18T04:18:57Z
dc.date.issued	2022-04-01
dc.identifier.citation	Process Biochemistry, 2022, 115, pp. 57-69
dc.identifier.issn	1359-5113
dc.identifier.issn	1873-3298
dc.identifier.uri	http://hdl.handle.net/10453/165109
dc.description.abstract	Hydrogen peroxide (H2O2) molecule, a neuromodulator in the central nervous system and the immune system, plays a vital role in the neural signal transmission, immune response and cell apoptosis. Real-time detecting H2O2 with high accuracy and sensitivity way is critically significant for the assessments of biological functions and pathogenic mechanisms towards diseases diagnostics. The in-situ electrochemical analysis has been widely used in the real-time sensing and detection of H2O2 for miniaturization feasibility and superior temporal spatial resolution. In this review paper, we summarized the recent advances in in vivo electrochemical analysis on H2O2, specifically including the electrochemical redox process of H2O2 on the electrode surface and variety of catalysts used for the electrochemical analysis with effectively improved selectivity and sensitivity. In particular, the novel technique of the photoelectrochemical (PEC) method for H2O2 detection was thoroughly discussed. The developments on the high selectivity analysis of H2O2 at the cellular and in vivo levels was summarized in details. Lastly, the challenges and prospects of the electrochemical sensors for H2O2 was proposed. This review is greatly helpful for the advancement of H2O2 electrochemical sensing towards biomedical applications.
dc.language	English
dc.publisher	ELSEVIER SCI LTD
dc.relation.ispartof	Process Biochemistry
dc.relation.isbasedon	10.1016/j.procbio.2022.01.025
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0601 Biochemistry and Cell Biology
dc.subject.classification	Biotechnology
dc.title	Recent advances in electrochemical analysis of hydrogen peroxide towards in vivo detection
dc.type	Journal Article
utslib.citation.volume	115
utslib.for	0601 Biochemistry and Cell Biology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access	*
dc.date.updated	2023-01-18T04:18:56Z
pubs.publication-status	Published
pubs.volume	115

Abstract:

Hydrogen peroxide (H2O2) molecule, a neuromodulator in the central nervous system and the immune system, plays a vital role in the neural signal transmission, immune response and cell apoptosis. Real-time detecting H2O2 with high accuracy and sensitivity way is critically significant for the assessments of biological functions and pathogenic mechanisms towards diseases diagnostics. The in-situ electrochemical analysis has been widely used in the real-time sensing and detection of H2O2 for miniaturization feasibility and superior temporal spatial resolution. In this review paper, we summarized the recent advances in in vivo electrochemical analysis on H2O2, specifically including the electrochemical redox process of H2O2 on the electrode surface and variety of catalysts used for the electrochemical analysis with effectively improved selectivity and sensitivity. In particular, the novel technique of the photoelectrochemical (PEC) method for H2O2 detection was thoroughly discussed. The developments on the high selectivity analysis of H2O2 at the cellular and in vivo levels was summarized in details. Lastly, the challenges and prospects of the electrochemical sensors for H2O2 was proposed. This review is greatly helpful for the advancement of H2O2 electrochemical sensing towards biomedical applications.

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http://hdl.handle.net/10453/165109