Liver-on-a-chip: Considerations, advances, and beyond.

Yang, Z; Liu, X; Cribbin, EM; Kim, AM; Li, JJ; Yong, K-T

Liver-on-a-chip: Considerations, advances, and beyond.

Yang, Z Liu, X Cribbin, EM Kim, AM Li, JJ Yong, K-T

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Publisher:: AIP Publishing
Publication Type:: Journal Article
Citation:: Biomicrofluidics, 2022, 16, (6), pp. 061502
Issue Date:: 2022-12

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Field	Value	Language
dc.contributor.author	Yang, Z
dc.contributor.author	Liu, X
dc.contributor.author	Cribbin, EM
dc.contributor.author	Kim, AM
dc.contributor.author	Li, JJ
dc.contributor.author	Yong, K-T
dc.date.accessioned	2023-01-18T05:19:17Z
dc.date.available	2022-10-25
dc.date.available	2023-01-18T05:19:17Z
dc.date.issued	2022-12
dc.identifier.citation	Biomicrofluidics, 2022, 16, (6), pp. 061502
dc.identifier.issn	1932-1058
dc.identifier.issn	1932-1058
dc.identifier.uri	http://hdl.handle.net/10453/165124
dc.description.abstract	The liver is the largest internal organ in the human body with largest mass of glandular tissue. Modeling the liver has been challenging due to its variety of major functions, including processing nutrients and vitamins, detoxification, and regulating body metabolism. The intrinsic shortfalls of conventional two-dimensional (2D) cell culture methods for studying pharmacokinetics in parenchymal cells (hepatocytes) have contributed to suboptimal outcomes in clinical trials and drug development. This prompts the development of highly automated, biomimetic liver-on-a-chip (LOC) devices to simulate native liver structure and function, with the aid of recent progress in microfluidics. LOC offers a cost-effective and accurate model for pharmacokinetics, pharmacodynamics, and toxicity studies. This review provides a critical update on recent developments in designing LOCs and fabrication strategies. We highlight biomimetic design approaches for LOCs, including mimicking liver structure and function, and their diverse applications in areas such as drug screening, toxicity assessment, and real-time biosensing. We capture the newest ideas in the field to advance the field of LOCs and address current challenges.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	AIP Publishing
dc.relation.ispartof	Biomicrofluidics
dc.relation.isbasedon	10.1063/5.0106855
dc.rights	This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in [Liver-on-a-chip: Considerations, advances, and beyond. Biomicrofluidics 16, 6 p061502 (2022)] https://doi.org/10.1063/5.0106855
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	0203 Classical Physics, 0915 Interdisciplinary Engineering, 1007 Nanotechnology
dc.subject.classification	Nanoscience & Nanotechnology
dc.title	Liver-on-a-chip: Considerations, advances, and beyond.
dc.type	Journal Article
utslib.citation.volume	16
utslib.location.activity	United States
utslib.for	0203 Classical Physics
utslib.for	0915 Interdisciplinary Engineering
utslib.for	1007 Nanotechnology
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
utslib.copyright.embargo	2023-11-08T00:00:00+1000Z
dc.date.updated	2023-01-18T05:19:13Z
pubs.issue	6
pubs.publication-status	Published online
pubs.volume	16
utslib.citation.issue	6

Abstract:

The liver is the largest internal organ in the human body with largest mass of glandular tissue. Modeling the liver has been challenging due to its variety of major functions, including processing nutrients and vitamins, detoxification, and regulating body metabolism. The intrinsic shortfalls of conventional two-dimensional (2D) cell culture methods for studying pharmacokinetics in parenchymal cells (hepatocytes) have contributed to suboptimal outcomes in clinical trials and drug development. This prompts the development of highly automated, biomimetic liver-on-a-chip (LOC) devices to simulate native liver structure and function, with the aid of recent progress in microfluidics. LOC offers a cost-effective and accurate model for pharmacokinetics, pharmacodynamics, and toxicity studies. This review provides a critical update on recent developments in designing LOCs and fabrication strategies. We highlight biomimetic design approaches for LOCs, including mimicking liver structure and function, and their diverse applications in areas such as drug screening, toxicity assessment, and real-time biosensing. We capture the newest ideas in the field to advance the field of LOCs and address current challenges.

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http://hdl.handle.net/10453/165124