Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies.

Lukomskyj, AO; Rao, N; Yan, L; Pye, JS; Li, H; Wang, B; Li, JJ

Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies.

Lukomskyj, AO Rao, N Yan, L Pye, JS Li, H Wang, B Li, JJ

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Publisher:: SPRINGER
Publication Type:: Journal Article
Citation:: Stem Cell Rev Rep, 2022, 18, (6), pp. 1926-1955
Issue Date:: 2022-08

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Field	Value	Language
dc.contributor.author	Lukomskyj, AO
dc.contributor.author	Rao, N
dc.contributor.author	Yan, L
dc.contributor.author	Pye, JS
dc.contributor.author	Li, H
dc.contributor.author	Wang, B
dc.contributor.author	Li, JJ
dc.date.accessioned	2023-01-18T05:25:46Z
dc.date.available	2022-01-21
dc.date.available	2023-01-18T05:25:46Z
dc.date.issued	2022-08
dc.identifier.citation	Stem Cell Rev Rep, 2022, 18, (6), pp. 1926-1955
dc.identifier.issn	2629-3269
dc.identifier.issn	2629-3277
dc.identifier.uri	http://hdl.handle.net/10453/165132
dc.description.abstract	Burn wounds are a devastating type of skin injury leading to severe impacts on both patients and the healthcare system. Current treatment methods are far from ideal, driving the need for tissue engineered solutions. Among various approaches, stem cell-based strategies are promising candidates for improving the treatment of burn wounds. A thorough search of the Embase, Medline, Scopus, and Web of Science databases was conducted to retrieve original research studies on stem cell-based tissue engineering treatments tested in preclinical models of burn wounds, published between January 2009 and June 2021. Of the 347 articles retrieved from the initial database search, 33 were eligible for inclusion in this review. The majority of studies used murine models with a xenogeneic graft, while a few used the porcine model. Thermal burn was the most commonly induced injury type, followed by surgical wound, and less commonly radiation burn. Most studies applied stem cell treatment immediately post-burn, with final endpoints ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most common stem cell type used in the included studies. Stem cells from a variety of sources were used, most commonly from adipose tissue, bone marrow or umbilical cord, in conjunction with an extensive range of biomaterial scaffolds to treat the skin wounds. Overall, the studies showed favourable results of skin wound repair in animal models when stem cell-based tissue engineering treatments were applied, suggesting that such strategies hold promise as an improved therapy for burn wounds.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	SPRINGER
dc.relation	http://purl.org/au-research/grants/nhmrc/1120249
dc.relation.ispartof	Stem Cell Rev Rep
dc.relation.isbasedon	10.1007/s12015-022-10341-z
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.mesh	Animals
dc.subject.mesh	Mesenchymal Stem Cell Transplantation
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Mice
dc.subject.mesh	Swine
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Wound Healing
dc.subject.mesh	Mesenchymal Stem Cells
dc.subject.mesh	Animals
dc.subject.mesh	Swine
dc.subject.mesh	Mice
dc.subject.mesh	Mesenchymal Stem Cell Transplantation
dc.subject.mesh	Tissue Engineering
dc.subject.mesh	Wound Healing
dc.title	Stem Cell-Based Tissue Engineering for the Treatment of Burn Wounds: A Systematic Review of Preclinical Studies.
dc.type	Journal Article
utslib.citation.volume	18
utslib.location.activity	United States
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	open_access	*
dc.date.updated	2023-01-18T05:25:42Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	18
utslib.citation.issue	6

Abstract:

Burn wounds are a devastating type of skin injury leading to severe impacts on both patients and the healthcare system. Current treatment methods are far from ideal, driving the need for tissue engineered solutions. Among various approaches, stem cell-based strategies are promising candidates for improving the treatment of burn wounds. A thorough search of the Embase, Medline, Scopus, and Web of Science databases was conducted to retrieve original research studies on stem cell-based tissue engineering treatments tested in preclinical models of burn wounds, published between January 2009 and June 2021. Of the 347 articles retrieved from the initial database search, 33 were eligible for inclusion in this review. The majority of studies used murine models with a xenogeneic graft, while a few used the porcine model. Thermal burn was the most commonly induced injury type, followed by surgical wound, and less commonly radiation burn. Most studies applied stem cell treatment immediately post-burn, with final endpoints ranging from 7 to 90 days. Mesenchymal stromal cells (MSCs) were the most common stem cell type used in the included studies. Stem cells from a variety of sources were used, most commonly from adipose tissue, bone marrow or umbilical cord, in conjunction with an extensive range of biomaterial scaffolds to treat the skin wounds. Overall, the studies showed favourable results of skin wound repair in animal models when stem cell-based tissue engineering treatments were applied, suggesting that such strategies hold promise as an improved therapy for burn wounds.

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http://hdl.handle.net/10453/165132