Scaffold-based regeneration of skeletal tissues to meet clinical challenges.

Li, JJ; Kaplan, DL; Zreiqat, H

Scaffold-based regeneration of skeletal tissues to meet clinical challenges.

Li, JJ Kaplan, DL Zreiqat, H

Permalink

Publisher:: ROYAL SOC CHEMISTRY
Publication Type:: Journal Article
Citation:: J Mater Chem B, 2014, 2, (42), pp. 7272-7306
Issue Date:: 2014-11-14

Closed Access

	Filename	Description	Size
	revised_materchemB.docx		11.79 MB	Unknown	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Li, JJ
dc.contributor.author	Kaplan, DL
dc.contributor.author	Zreiqat, H
dc.date.accessioned	2023-01-18T05:34:54Z
dc.date.available	2023-01-18T05:34:54Z
dc.date.issued	2014-11-14
dc.identifier.citation	J Mater Chem B, 2014, 2, (42), pp. 7272-7306
dc.identifier.issn	2050-750X
dc.identifier.issn	2050-7518
dc.identifier.uri	http://hdl.handle.net/10453/165142
dc.description.abstract	The management and reconstruction of damaged or diseased skeletal tissues have remained a significant global healthcare challenge. The limited efficacy of conventional treatment strategies for large bone, cartilage and osteochondral defects has inspired the development of scaffold-based tissue engineering solutions, with the aim of achieving complete biological and functional restoration of the affected tissue in the presence of a supporting matrix. Nevertheless, significant regulatory hurdles have rendered the clinical translation of novel scaffold designs to be an inefficient process, mainly due to the difficulties of arriving at a simple, reproducible and effective solution that does not rely on the incorporation of cells and/or bioactive molecules. In the context of the current clinical situation and recent research advances, this review will discuss scaffold-based strategies for the regeneration of skeletal tissues, with focus on the contribution of bioactive ceramic scaffolds and silk fibroin, and combinations thereof, towards the development of clinically viable solutions.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	ROYAL SOC CHEMISTRY
dc.relation.ispartof	J Mater Chem B
dc.relation.isbasedon	10.1039/c4tb01073f
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0303 Macromolecular and Materials Chemistry, 0903 Biomedical Engineering
dc.title	Scaffold-based regeneration of skeletal tissues to meet clinical challenges.
dc.type	Journal Article
utslib.citation.volume	2
utslib.location.activity	England
utslib.for	0303 Macromolecular and Materials Chemistry
utslib.for	0903 Biomedical Engineering
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology/School of Biomedical Engineering
utslib.copyright.status	closed_access	*
dc.date.updated	2023-01-18T05:34:47Z
pubs.issue	42
pubs.publication-status	Published
pubs.volume	2
utslib.citation.issue	42

Abstract:

The management and reconstruction of damaged or diseased skeletal tissues have remained a significant global healthcare challenge. The limited efficacy of conventional treatment strategies for large bone, cartilage and osteochondral defects has inspired the development of scaffold-based tissue engineering solutions, with the aim of achieving complete biological and functional restoration of the affected tissue in the presence of a supporting matrix. Nevertheless, significant regulatory hurdles have rendered the clinical translation of novel scaffold designs to be an inefficient process, mainly due to the difficulties of arriving at a simple, reproducible and effective solution that does not rely on the incorporation of cells and/or bioactive molecules. In the context of the current clinical situation and recent research advances, this review will discuss scaffold-based strategies for the regeneration of skeletal tissues, with focus on the contribution of bioactive ceramic scaffolds and silk fibroin, and combinations thereof, towards the development of clinically viable solutions.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/165142